Changing of HCV Clade Pattern in Iran; the Possible Means for Something Good

Afzal, Muhammad Sohail; Anjum, Sadia; Zaidi, Najam us Sahar Sadaf

doi:10.5812/hepatmon.11879

Cited by 14 publications

(7 citation statements)

References 7 publications

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“…The recent changes in the genotype distribution of HCV have also fueled this epidemic[ 6 ]. High rates of mutation in HCV genome have resulted in the emergence of seven major genotypes and at least 67 subtypes[ 7 ].…”

Section: To the Editormentioning

confidence: 99%

“…The most prevalent subtype in Iran is 1a, followed by 3a and 1b. Over the last decade, however, a gradual decrease in the frequency of subtypes 1a and 1b and an increase in subtype 3a have been reported due to changes in the routes of transmission of HCV from blood transfusion to injecting drug use[ 6 , 9 - 12 ]. These changes should be taken in to consideration to establish better strategies for managing the silent epidemic of hepatitis C in Iran.…”

Section: To the Editormentioning

confidence: 99%

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Lurking epidemic of hepatitis C virus infection in Iran: A call to action

Taherkhani

Farshadpour

2017

WJH

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Despite having a relatively low prevalence in the Iranian general population, the burden of hepatitis C virus (HCV) infection is on the rise, and hepatitis C is predicted to be the most important leading cause of viral hepatitis-related mortality in the near future in Iran. The recent population-based epidemiological studies have revealed the predominant role of injecting drug use in increasing prevalence of HCV infection. Undoubtedly, new management paradigm is required to drive down the rising wave of hepatitis C in Iran. Priority should be given to young injecting drug users as the cornerstone of the lurking epidemic of HCV infection in Iran.

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Section: To the Editormentioning

confidence: 99%

Section: To the Editormentioning

confidence: 99%

Lurking epidemic of hepatitis C virus infection in Iran: A call to action

Taherkhani

Farshadpour

2017

WJH

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“…The current standard of care antiviral therapies includes interferon based and interferon free direct acting antivirals (DAAs) [6]. Interferon based regimes have side effects where as DAAs are very costly to manage for treatment of all infected individuals [7,8]. Keeping the current scenario in mind, the monitoring of HCV prevalence across the country is the need of the hour.…”

Section: Letter To Editormentioning

confidence: 99%

Does HCV Prevalence in Blood Donors Reflects the Incidence in General Population? A Study for Global Impact

Afzal¹

2017

J Antivir Antiretrovir

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“…Determination of HCV genotypes in different parts of the country is necessary to facilitate preventive strategies and treatment options. The prevalence of HCV genotypes in an area may alter over the time because of changing in route of infection (16,17), therefore repeating of HCV genotyping tests in an area every few years is helpful. The present study aimed to evaluate distribution of HCV genotypes in the Yazd province of Iran in 2015.…”

Section: Introduction *mentioning

confidence: 99%

Distribution of Hepatitis C virus genotypes in Yazd, Central Province of Iran: increasing the mixed genotypes

et al. 2016

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Background and Aims: Different hepatitis C virus (HCV) genotypes have characteristic geographical distribution. Identification of HCV genotype is an important factor in the progression, clinical outcome and therapy of HCV infection. The aim of this study was to determine the prevalence of HCV genotypes among HCV-RNA positive patients in Yazd, Iran. Materials and Methods: In this cross-sectional study, 150 HCV-infected individuals with detectable plasma HCV RNA levels were enrolled from January to August 2015. HCV-RNA was extracted from plasma samples and retro-transcribed to c-DNA. Then HCV genotypes 1, 2, 3a, 4 were determined using a PCR based genotyping kit. Results: A total of 150 HCV-positive patients with mean age 40.45±11.83 were enrolled in the study. 89.3% of participant were males and 10.7% were females. The most common genotype was 3a (52%), followed by 1a (28%). Mixed-genotype infection was 20% and the most prevalent mixed genotype was 3a/1a (83% of mixed genotypes). The other genotypes were 1a/1b/3a in 10%, 3a/2 and 1a/2/3a both in 3% of patients with mixed HCV genotypes. Conclusions: Unlike other regions of Iran, Genotypes 3a was predominant in HCV-RNA positive patients in Yazd province. Also, HCV mixed-genotype infections were more common than previously estimated in other studies from different parts of the country.

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Changing of HCV Clade Pattern in Iran; the Possible Means for Something Good

Cited by 14 publications

References 7 publications

Lurking epidemic of hepatitis C virus infection in Iran: A call to action

Lurking epidemic of hepatitis C virus infection in Iran: A call to action

Does HCV Prevalence in Blood Donors Reflects the Incidence in General Population? A Study for Global Impact

Distribution of Hepatitis C virus genotypes in Yazd, Central Province of Iran: increasing the mixed genotypes

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