Changing spectrum of hair and scalp disorders over the last decade in a tertiary medical centre

Lyakhovitsky, Anna; Tzanani, I.; Gilboa, Shlomo; Segal, Omer; Galili, Eran; Baum, Sharon; Barzilai, Aviv

doi:10.1111/jdv.18570

Cited by 7 publications

(5 citation statements)

References 63 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…An Israeli skin clinic reported that hair loss-related visits increased from 1.24% in 2010 to 9.44% in 2020. Furthermore, the highest increase was noted in the prevalence of androgenetic alopecia (AGA), from 17% in 2010 to 32% in 2020 35 . Safavi et al 36 indicated that the estimated incidence of AA was 20.2 per 100,000 person-years from 1975 to 1989.…”

Section: Current Hair Loss Situationmentioning

confidence: 99%

Status of research on the development and regeneration of hair follicles

Liu,

Xu,

Meng

et al. 2024

Int. J. Med. Sci.

View full text Add to dashboard Cite

Hair loss, or alopecia, is a prevalent condition in modern society that imposes substantial mental and psychological burden on individuals. The types of hair loss, include androgenetic alopecia, alopecia areata, and telogen effluvium; of them, androgenetic alopecia is the most common condition. Traditional treatment modalities mainly involve medical options, such as minoxidil, finasteride and surgical interventions, such as hair transplantation. However, these treatments still have many limitations. Therefore, exploring the pathogenesis of hair loss, specifically focusing on the development and regeneration of hair follicles (HFs), and developing new strategies for promoting hair regrowth are essential. Some emerging therapies for hair loss have gained prominence; these therapies include low-level laser therapy, micro needling, fractional radio frequency, platelet-rich plasma, and stem cell therapy. The aforementioned therapeutic strategies appear promising for hair loss management. In this review, we investigated the mechanisms underlying HF development and regeneration. For this, we studied the structure, development, cycle, and cellular function of HFs. In addition, we analyzed the symptoms, types, and causes of hair loss as well as its current conventional treatments. Our study provides an overview of the most effective regenerative medicine-based therapies for hair loss.

show abstract

Section: Current Hair Loss Situationmentioning

confidence: 99%

Status of research on the development and regeneration of hair follicles

Liu,

Xu,

Meng

et al. 2024

Int. J. Med. Sci.

View full text Add to dashboard Cite

show abstract

“…A study of Korean men documented that the average age of men who developed AGA in the years from 2006 to 2010 decreased from 34.1 to 31.6 years [92]. A study of a population in Israel over the course of a decade (2010-2020) measured an increased rate of AGA from 17% to 32% [93] in the general population.…”

Section: Perspectives On the Culture Of Hair Care In Africamentioning

confidence: 99%

Cosmetopoeia of African Plants in Hair Treatment and Care: Topical Nutrition and the Antidiabetic Connection?

Ajao,

Sadgrove

2024

Diversity

View full text Add to dashboard Cite

To make the distinction against pharmaceuticals, natural product medicines are more accurately denoted as nutritional therapies. In the context of topical therapies targeting dermatological conditions, nutritional therapy may explain the mechanism of ethnocosmetic plants used in hair treatment and care. Inspired by emerging theories of a connection between dysregulated glucose metabolism and hair loss, the current review of the literature focused on African plants used to target hair conditions in general, such as alopecia or scalp dermis infections, with a cross-examination of the potential of the species to alleviate issues with glucose metabolism. We distinguish between topical nutrition and sterilization (i.e., dandruff and lice). Sixty-eight plants were identified as an African treatment for alopecia, dandruff, lice, and tinea. Fifty-eight of the species have potential as antidiabetic treatments when taken orally. The family Lamiaceae was the most represented (six spp.), followed by Fabaceae and Asteraceae (five spp. each). Most species are herbs, and the most used plant part is the leaf. Thirty of the sixty species have research associated with hair growth and general hair care, with studies focused on 5α-reductase inhibition, biomarkers such as vascular endothelial growth factor, and the rate of telogen to anagen phase transition. While studies tend to conceptualize the mechanisms of these medicinal species similarly to pharmaceuticals, the current review argues that a nutritional interpretation is more appropriate, where a general improvement to local glucose metabolism may play a role.

show abstract

“…The highest disease prevalence (10–50%) is reported in children, in particular those with a positive family history of AA [ 6 ]. An increasing number of patients visit tertiary dermatology centers due to AA, the second most common form of non-cicatricial alopecia [ 7 ].…”

Section: Introductionmentioning

confidence: 99%

Deciphering the Complex Immunopathogenesis of Alopecia Areata

Šutić Udović,

Hlača,

Massari

et al. 2024

IJMS

View full text Add to dashboard Cite

Alopecia areata (AA) is an autoimmune-mediated disorder in which the proximal hair follicle (HF) attack results in non-scarring partial to total scalp or body hair loss. Despite the growing knowledge about AA, its exact cause still needs to be understood. However, immunity and genetic factors are affirmed to be critical in AA development. While the genome-wide association studies proved the innate and acquired immunity involvement, AA mouse models implicated the IFN-γ- and cytotoxic CD8+ T-cell-mediated immune response as the main drivers of disease pathogenesis. The AA hair loss is caused by T-cell-mediated inflammation in the HF area, disturbing its function and disrupting the hair growth cycle without destroying the follicle. Thus, the loss of HF immune privilege, autoimmune HF destruction mediated by cytotoxic mechanisms, and the upregulation of inflammatory pathways play a crucial role. AA is associated with concurrent systemic and autoimmune disorders such as atopic dermatitis, vitiligo, psoriasis, and thyroiditis. Likewise, the patient’s quality of life (QoL) is significantly impaired by morphologic disfigurement caused by the illness. The patients experience a negative impact on psychological well-being and self-esteem and may be more likely to suffer from psychiatric comorbidities. This manuscript aims to present the latest knowledge on the pathogenesis of AA, which involves genetic, epigenetic, immunological, and environmental factors, with a particular emphasis on immunopathogenesis.

show abstract

Changing spectrum of hair and scalp disorders over the last decade in a tertiary medical centre

Cited by 7 publications

References 63 publications

Status of research on the development and regeneration of hair follicles

Status of research on the development and regeneration of hair follicles

Cosmetopoeia of African Plants in Hair Treatment and Care: Topical Nutrition and the Antidiabetic Connection?

Deciphering the Complex Immunopathogenesis of Alopecia Areata

Contact Info

Product

Resources

About