Nowadays the micro and small scale enterprise survival factors are becoming prevailing issues. Objective of the study is to identify the determinants of women entrepreneurs' business survival in East Gojjam Zone Administration. In this study, both qualitative and quantitative types of data were used. The research design that was used in this study is Retrospective research design. From the total population of 73, sample size of 259 has been selected by using Yamane (1967) formula. In this study, Cox Proportional Hazards Model has been utilized to identify business survival factors. The study revealed that mainly form of business ownership, entrepreneurship training, ability to exploit opportunity, need for achievement, motivation to run business, access to credit finance, market linkage, customer handling skill and developing business plan before starting business have an effect on women MSE's survival.