Changing trends in antimicrobial susceptibility pattern of bacterial isolates in a burn unit

Singh, Narendra; Rani, Mayuri; Gupta, Kanupriya; Sagar, Tanu

doi:10.1016/j.burns.2017.01.016

Cited by 43 publications

(41 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…aureus (12%) has been reported in other studies [1,5]; the prevalence of P. aeruginosa in the present study was comparable to that in the previous report [5]. Moreover, S. aureus (25%) followed by P.…”

Section: Discussionsupporting

confidence: 88%

“…However, other Gram negative isolates like Acinetobacter may also be found in burn wounds [1,5,29]. In the present study, E. coli (28.4%) was the most prevalent bacterial species as similar to other reports [13] followed by P. aeruginosa (22.2%), S. aureus (19.6%), K. pneumoniae (16.4%), and coagulase-negative staphylococci (13.3%) ( Tables 1 and 2).…”

Section: Discussionsupporting

confidence: 87%

“…Gram negative organisms have been recognized as dominant pathogen in burn patients [18,[26][27][28] and among these, the most frequent species were Klebsiella, E. coli, Pseudomonas and Proteus [1,4,10].…”

Section: Discussionmentioning

confidence: 99%

“…Septic processes account for 73% of death within the initial five days of post-burn [1][2][3][4][5]. Furthermore, exudate around burn wound is highly nutritive for growth and proliferation of microorganism [1,6].…”

Section: Introductionmentioning

confidence: 99%

“…Furthermore, exudate around burn wound is highly nutritive for growth and proliferation of microorganism [1,6]. Skin is regarded as the first line defense against pathogens exposure; however, any thermal injury results in physical barrier disruption leading to pathogen invasion.…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Antimicrobial susceptibility patterns and CTX-M β-lactamase producing clinical isolates from burn patients in Islamabad, Pakistan

Hussain¹,

Munir²,

Fatima³

et al. 2017

APJTD

View full text Add to dashboard Cite

Section: Discussionsupporting

confidence: 88%

Section: Discussionsupporting

confidence: 87%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Antimicrobial susceptibility patterns and CTX-M β-lactamase producing clinical isolates from burn patients in Islamabad, Pakistan

Hussain¹,

Munir²,

Fatima³

et al. 2017

APJTD

View full text Add to dashboard Cite

Basic research and clinical exploration of cold atmospheric plasma for skin wounds

Gao

Wang

et al. 2023

Bioengineering & Transla Med

View full text Add to dashboard Cite

Skin wounds, such as burns, diabetic foot ulcers, pressure sores, and wounds formed after laser or surgical treatment, comprise a very high proportion of dermatological disorders. Wounds are treated in a variety of ways; however, some wounds are greatly resistant, resulting in delayed healing and an urgent need to introduce new alternatives. Our previous studies have shown that cold atmospheric plasma (CAP) has antibacterial activity and promotes cell proliferation, differentiation, and migration in vitro. To further advance the role of CAP in wound healing, we evaluated the safety and efficacy of CAP in vitro by irradiation of common refractory bacteria on the skin, irradiation of normal skin of rats and observing reactions, treatment of scald wounds in rats, and treating clinically common acute wounds. Our findings revealed that CAP can eliminate refractory skin bacteria in vitro; CAP positively affected wound healing in a rat scalding wound model; and direct CAP irradiation of low intensity and short duration did not lead to skin erythema or edema. CAP promises to be a new, economical, and safe means of wound treatment.

show abstract

Biofilm generation and antibiotic resistant profile of extensive and multidrug resistant Pseudomonas aeruginosa from burn patients in Ahvaz: A cross‐sectional study

Akrami,

Ekrami,

Avarvand

2024

Health Science Reports

View full text Add to dashboard Cite

Background and AimsMultidrug and extensive drug‐resistant Pseudomonas aeruginosa was extracted from burn patients referring to burn centers in southwest Iran so that biofilm generation and antibiotic resistance could be investigated.MethodsA specific primer was used to confirm all our considered 110 P. aeruginosa culture‐positive reports on 345 burn patients. The resistance of P. aeruginosa to seven antibiotics and Colistin with minimum inhibitory concentration (MIC) was assessed. Biofilm formation was assessed by the phenotypic study of specimens under Congo red agar and microtiter plate assays.ResultsOne hundred and 10 clinical P. aeruginosa isolates taken from burn wound infections were validated. Among P. aeruginosa isolates, Piperacillin, Ceftazidime, Maeropenem, Gentamycin, and Gatifloacin had the highest resistance to antibiotics, while Ticarcillin‐Clavulanic acid and Ceftolozane‐Tazobactam showed the least resistance. MICs were then evaluated via the E test. Seven isolates were resistant to colistin. Colistin reference MICs for multidrug‐resistant P. aeruginosa prevalence was 38%, while it was 22% for extensively drug‐resistant (XDR) P. aeruginosa. One P. aeruginosa was pandrug‐resistant (PDR). Under Congo red agar test, 66 isolates (67%) formed biofilms and black colonies, whereas 44 isolates (50%) had red colonies. In MTP, 76% formed biofilm. 40%, 32%, 21% of the isolates were strong, moderate, and weak biofilm formers, respectively, while 43% did not form biofilms.ConclusionThe P. aeruginosa resistance to antimicrobial agents has largely challenged the control of the infection. Accordingly, a higher resistance occurred when the isolates were transferred to the patients. Less than 50% P. aeruginosa samples generated strong biofilms. Consequently, hygienic measurements are essential to inhibit P. aeruginosa transmission to hospitalized patients.

show abstract

Changing trends in antimicrobial susceptibility pattern of bacterial isolates in a burn unit

Cited by 43 publications

References 16 publications

Antimicrobial susceptibility patterns and CTX-M β-lactamase producing clinical isolates from burn patients in Islamabad, Pakistan

Antimicrobial susceptibility patterns and CTX-M β-lactamase producing clinical isolates from burn patients in Islamabad, Pakistan

Basic research and clinical exploration of cold atmospheric plasma for skin wounds

Biofilm generation and antibiotic resistant profile of extensive and multidrug resistant Pseudomonas aeruginosa from burn patients in Ahvaz: A cross‐sectional study

Contact Info

Product

Resources

About