Changing Trends in Etiology-Based Annual Mortality From Chronic Liver Disease, From 2007 Through 2016

Kim, Dong‐Hee; Li, Andrew A.; Gadiparthi, Chiranjeevi; Khan, Muhammad Ali; Cholankeril, George; Glenn, Jeffrey S.

doi:10.1053/j.gastro.2018.07.008

Cited by 185 publications

(178 citation statements)

References 36 publications

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“…11,12 A study using the national US mortality database reported an increase in the mortality of NAFLD from an annual rate of 6.1% in 2007-2013 to 11.3% in 2013-2016. 13 Globally, liver-specific mortality among patients with NAFLD was 0.77 per 1000 person-years with an overall mortality of 15.44 per 1000 persons-years. 3 Given the current global landscape of NAFLD, concerted efforts to better understand the modifiable predictors of NAFLD globally and regionally are warranted to retard and hopefully reverse the currently rising rates of disease burden and increase in healthcare utilization.…”

Section: Introductionmentioning

confidence: 98%

“…Not surprisingly, NAFLD‐related advanced fibrosis is on the rise at an accelerated pace in American adults, which translates to an increase in overall and cause‐specific mortality . A study using the national US mortality database reported an increase in the mortality of NAFLD from an annual rate of 6.1% in 2007‐2013 to 11.3% in 2013‐2016 . Globally, liver‐specific mortality among patients with NAFLD was 0.77 per 1000 person‐years with an overall mortality of 15.44 per 1000 persons‐years .…”

Section: Introductionmentioning

confidence: 99%

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Diet quality and its association with nonalcoholic fatty liver disease and all‐cause and cause‐specific mortality

Yoo

Kim

Vazquez‐Montesino

et al. 2020

Liver International

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Background & Aims Healthy diet has been recommended for nonalcoholic fatty liver disease (NAFLD), although it is not clear whether improving diet quality can prevent mortality. We aim to assess the impact of quality of diet on NAFLD and mortality in subjects with and without NAFLD. Methods We performed cohort study using the Third National Health and Nutrition Examination Survey from 1988 to 1994 and linked mortality data through 2015. We used the Healthy Eating Index (HEI) scores to define diet quality, with higher HEI scores (Q4) indicating better adherence to dietary recommendations. NAFLD was defined as ultrasonographic hepatic steatosis. Results Multivariate analysis showed that subjects with higher diet quality were inversely associated with NAFLD in a dose‐dependent manner. During the median follow‐up of 23 years, having a higher diet quality was associated with reduction in risk of all‐cause mortality in the age, sex, Race/ethnicity‐adjusted hazard ratio (HR) (Q4, HR: 0.60, 95% CI: 0.52‐0.68) and the multivariate model (Q4, HR: 0.81, 95% CI: 0.71‐0.92). Higher diet quality was associated with a lower risk for all‐cause mortality in subjects without NAFLD; however, this protective association with diet quality was not noted in those with NAFLD. Furthermore, a high diet quality was associated with a lower risk for cancer‐related mortality in the total population and among those without NAFLD. This association was not noted in those with NAFLD. Conclusions High diet quality was inversely associated with NAFLD and was positively associated with a lower risk for cancer‐related and all‐cause mortality in those without NAFLD.

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Section: Introductionmentioning

confidence: 98%

Section: Introductionmentioning

confidence: 99%

Diet quality and its association with nonalcoholic fatty liver disease and all‐cause and cause‐specific mortality

Yoo

Kim

Vazquez‐Montesino

et al. 2020

Liver International

Self Cite

View full text Add to dashboard Cite

show abstract

“…1,2 Not surprisingly, a recent study showed that NAFLD-related advanced fibrosis is on the rise at an accelerated pace in American adults, 3 which may result in increased overall mortality and cause-specific death. 6 These are particularly ominous trends, especially in the absence of approved pharmacologic therapy for NAFLD. 6 These are particularly ominous trends, especially in the absence of approved pharmacologic therapy for NAFLD.…”

Section: Introductionmentioning

confidence: 99%

Depression is associated with non‐alcoholic fatty liver disease among adults in the United States

Kim

Yoo

et al. 2019

Aliment Pharmacol Ther

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Background: Currently, the relationship between depression and non-alcoholic fatty liver disease (NAFLD) is not clearly defined. Aim:To determine whether depression is associated with NAFLD and NAFLD-related advanced fibrosis in a large population sample. Methods: We performed a cross-sectional analysis using the 2007-2016 National Health and Nutrition Examination Survey database among adults (20 years or older) in the United States (US). Depression and functional impairment due to depression were assessed with the Patient Health Questionnaire (PHQ-9). NAFLD was defined by utilising the US fatty liver index (USFLI), hepatic steatosis index (HSI) and the fatty liver index (FLI) in the absence of other causes of chronic liver disease. The presence and absence of advanced fibrosis in NAFLD were defined by Fibrosis-4 score.Results: Of the 10 484 subjects (mean age 47.0 years; 48.8% men), the prevalence of depression and functional impairment due to depression was higher in subjects with NAFLD than in those without. Compared to subjects without depression, those with depression were 1.6-2.2-fold more likely to have NAFLD. In our multivariate analyses, depression_med was associated with increased risk of NAFLD using USFLI (odds ratio [OR] 1.48 95% confidence interval [CI] 1.17-1.87), HSI (OR 1.51 95% CI 1.04-2.19) and FLI (OR 2.01 95% CI 1.65-2.48), respectively. The addition of diabetes, obesity and lipid profile to the model reduced the ORs for depression, but the significance persisted. Depression was not associated with NAFLD-related advanced fibrosis. Conclusions:In a nationally representative sample of US adults, depression was independently associated with NAFLD. | 591KIM et al.

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“…NAFLD includes simple steatosis (SS) and nonalcoholic steatohepatitis (NASH), which may advance to cirrhosis and hepatocellular carcinoma (HCC) . NAFLD‐related mortality, attributing to hepatic diseases (ie, cirrhosis, its complications, and HCC) and extra‐hepatic diseases (ie, chronic kidney disease, cardiovascular diseases [CVD], cerebrovascular disorders, and malignancies), continues to increase in contrast to decreasing trends in viral hepatitis‐related mortality . Nonetheless, the need for noninvasive diagnosis and treatment of NAFLD remain unmet …”

Section: Introductionmentioning

confidence: 99%

Helicobacter pylori infection and nonalcoholic fatty liver disease: Time for large clinical trials evaluating eradication therapy

Polyzos

2019

Helicobacter

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Changing Trends in Etiology-Based Annual Mortality From Chronic Liver Disease, From 2007 Through 2016

Cited by 185 publications

References 36 publications

Diet quality and its association with nonalcoholic fatty liver disease and all‐cause and cause‐specific mortality

Diet quality and its association with nonalcoholic fatty liver disease and all‐cause and cause‐specific mortality

Depression is associated with non‐alcoholic fatty liver disease among adults in the United States

Helicobacter pylori infection and nonalcoholic fatty liver disease: Time for large clinical trials evaluating eradication therapy

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