Channel Blockers Reduce Angiotensin II-Induced Superoxide Generation and Inhibit Lectin-Like Oxidized Low-Density Lipoprotein Receptor-1 Expression in Endothelial Cells

Toba, Hiroe; Shimizu, Takahiro; Miki, Shunsuke; Inoue, Riyako; Yoshimura, Akiko; Tsukamoto, Rie; Sawai, Naoki; Kobara, Miyuki; Nakata, Tetsuo

doi:10.1291/hypres.29.105

Cited by 25 publications

(19 citation statements)

References 39 publications

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“…En-Hui YAO 1) , Noboru FUKUDA 1), 2) , Taro MATSUMOTO 3) , Naohiko KOBAYASHI 4) , Mayumi KATAKAWA 1) , Chii YAMAMOTO 1) , Akiko TSUNEMI 1) , Ryo SUZUKI 1) , Takahiro UENO 1) …”

Section: Losartan Improves the Impaired Function Of Endothelial Progeunclassified

“…In addition, unlike other antihypertensive drugs, ARBs are reported to have cardiovascular protective effects. The protective effects of ARBs with respect to vascular injury are associated with the inhibitions of Ang IIinduced vascular growth (1), extracellular matrix formation (2), and oxidative stress (3). Oxidative stress has emerged as a common theme of many conditions associated with shortened lifespan, including hypertension.…”

Section: Introductionmentioning

confidence: 99%

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Losartan Improves the Impaired Function of Endothelial Progenitor Cells in Hypertension via an Antioxidant Effect

et al. 2007

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“…En-Hui YAO 1) , Noboru FUKUDA 1), 2) , Taro MATSUMOTO 3) , Naohiko KOBAYASHI 4) , Mayumi KATAKAWA 1) , Chii YAMAMOTO 1) , Akiko TSUNEMI 1) , Ryo SUZUKI 1) , Takahiro UENO 1) …”

Section: Losartan Improves the Impaired Function Of Endothelial Progeunclassified

Section: Introductionmentioning

confidence: 99%

Losartan Improves the Impaired Function of Endothelial Progenitor Cells in Hypertension via an Antioxidant Effect

et al. 2007

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“…They also prevent Ang-II-induced increase in LOX-1. The salutary effects of calcium channel blockers in atherogenesis include the inhibition of the expression of LOX-1 (Toba et al 2006). LOX-1 gene polymorphisms also suggest the potential role of LOX-1 in cardiovascular diseases.…”

Section: The Effects Of Antiatherosclerotic Drugsmentioning

confidence: 99%

Lectin‐like Oxidized Low‐density Lipoprotein Receptor‐1, a New Promising Target for the Therapy of Atherosclerosis?

Chen

Zhang

2007

Cardiovascular Drug Reviews

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Endothelial activation and dysfunction induced by oxidized modified low-density lipoprotein (ox-LDL) is one of the key steps in the initiation of atherosclerosis. Recent studies have shown that a new lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) mediates the recognition and internalization of ox-LDL. LOX-1 is the main receptor for ox-LDL and may play an important role in the pathogenesis of hypertension, diabetes, and, especially, of atherosclerosis. The potential role of LOX-1 in the pathogenesis of atherosclerosis includes: endocytosis of ox-LDL, expression co-location with atherosclerosis enhanced by atherosclerosis-related risk factors, elevated LOX-1 protein in cardiovascular disease, effects related to atherosclerosis and eliminated by antiatherosclerotic drugs. Identification and regulation of LOX-1 and understanding its signal transduction pathways might improve our insight toward the pathogenesis of atherosclerosis and provide a selective treatment approach. LOX-1 might be a potential and promising target for the development of novel antiatherosclerotic drugs. However, due to limited knowledge about LOX-1, there are still many questions to be answered.

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“…They also found that two nights of nCPAP therapy decreased ADM levels significantly (28). It has been recently postulated that an inflammatory process plays a crucial role in the pathogenesis of atherosclerosis, which in turn can lead to various cardiovascular disorders (29)(30)(31). In a previous study, we reported that the circulating intercellular adhesion molecule-1 (ICAM-1) level in patients with OSAS was significantly increased compared to that in the control group, suggesting that OSAS-induced hypoxia may induce the activation of ICAM-1 and the inflammation of the endothelium in patients with OSAS (8,9).…”

Section: Fig 5 Correlation Between Circulating Adm Levels and A: Spmentioning

confidence: 99%

Effect of Nasal Continuous Positive Airway Pressure Treatment on Plasma Adrenomedullin Levels in Patients with Obstructive Sleep Apnea Syndrome: Roles of Nocturnal Hypoxia and Oxidant Stress

Yamamoto¹,

Teramoto²,

Yamaguchi³

et al. 2007

Hypertens Res

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Note from the Editor-in-ChiefDuplicate publication of essentially the same data constitutes a violation of copyright law and of the ethics of scientific publication. When there is doubt about the common source, overlapping, or coincidence of data in articles that are based on the same study, the author(s) must disclose any information about their contribution being under consideration or accepted by another journal at the time of submission of a manuscript. Kazuyuki Shimada Editor-in-Chief Hypertension Research

show abstract

Channel Blockers Reduce Angiotensin II-Induced Superoxide Generation and Inhibit Lectin-Like Oxidized Low-Density Lipoprotein Receptor-1 Expression in Endothelial Cells

Cited by 25 publications

References 39 publications

Losartan Improves the Impaired Function of Endothelial Progenitor Cells in Hypertension via an Antioxidant Effect

Losartan Improves the Impaired Function of Endothelial Progenitor Cells in Hypertension via an Antioxidant Effect

Lectin‐like Oxidized Low‐density Lipoprotein Receptor‐1, a New Promising Target for the Therapy of Atherosclerosis?

Effect of Nasal Continuous Positive Airway Pressure Treatment on Plasma Adrenomedullin Levels in Patients with Obstructive Sleep Apnea Syndrome: Roles of Nocturnal Hypoxia and Oxidant Stress

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