Chaperone proteins and peroxisomal protein import

Jonge, W. de; Tabak, Henk F.; Braakman, Ineke

doi:10.1007/b136669

Cited by 3 publications

(2 citation statements)

References 163 publications

(138 reference statements)

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“…In addition, these organelles contain an import machinery capable of importing completely folded proteins [76][77][78][79] , and have a controlled way of proliferation [80][81][82] . So, peroxisomes have the same origin as secretory vesicles and are thus candidates for alternative trafficking of proteins.…”

Section: Engineering Membrane Trafficking As a Novel Conceptmentioning

confidence: 99%

Peroxicretion, a Novel Tool for Engineering Membrane Trafficking

Sagt¹

2012

Crosstalk and Integration of Membrane Trafficking Pathways

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Section: Engineering Membrane Trafficking As a Novel Conceptmentioning

confidence: 99%

Peroxicretion, a Novel Tool for Engineering Membrane Trafficking

Sagt¹

2012

Crosstalk and Integration of Membrane Trafficking Pathways

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“…The removal of the receptor is driven by ATP hydrolysis whereas the actual translocation of the protein does not require any energy expenditure. Since the export of the receptor drives the import of the cargo, this "piggyback ride" of proteins across peroxisomal membrane is sometimes referred to as "export-driven import" [1318,1319].…”

Section: •Machines For Protein Import By Peroxisomementioning

confidence: 99%

Stochastic mechano-chemical kinetics of molecular motors: a multidisciplinary enterprise from a physicist's perspective

Chowdhury

2012

Preprint

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A molecular motor is made of either a single macromolecule or a macromolecular complex. Just like their macroscopic counterparts, molecular motors "transduce" input energy into mechanical work. All the nanomotors considered here operate under isothermal conditions far from equilibrium. Moreover, one of the possible mechanisms of energy transduction, called Brownian ratchet, does not even have any macroscopic counterpart. But, molecular motor is not synonymous with Brownian ratchet; a large number of molecular motors execute a noisy power stroke, rather than operating as Brownian ratchet. We review not only the structural design and stochastic kinetics of individual single motors, but also their coordination, cooperation and competition as well as the assembly of multimodule motors in various intracellular kinetic processes. Although all the motors considered here execute mechanical movements, efficiency and power output are not necessarily good measures of performance of some motors. Among the intracellular nano-motors, we consider the porters, sliders and rowers, pistons and hooks, exporters, importers, packers and movers as well as those that also synthesize, manipulate and degrade "macromolecules of life". We review mostly the quantitative models for the kinetics of these motors. We also describe several of those motordriven intracellular stochastic processes for which quantitative models are yet to be developed. In part I, we discuss mainly the methodology and the generic models of various important classes of molecular motors. In part II, we review many specific examples emphasizing the unity of the basic mechanisms as well as diversity of operations arising from the differences in their detailed structure and kinetics. Multi-disciplinary research is presented here from the perspective of physicists.

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