Chapter 15. Antifungal Chemotherapy

Heeres, Jan; Bossche, H. : Van den

doi:10.1016/s0065-7743(08)60376-0

Cited by 5 publications

(2 citation statements)

References 71 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Sincesynergism was demonstrated between ketoconazole, a promising antimycotic agent (9), and amphotericin B and other fungitoxicants (lo), it was also desired to determine if there would be any synergism between the most active of the alkynols and ketoconazole. EXPERIMENTAL SECT'ION Some compounds were obtained from commercial sourcesI.…”

Section: Aspergillus Niger Trichoderma Viride Myrothecium Verrucarimentioning

confidence: 99%

Antifungal properties of 2-n-Alkyn-1-ols

Gershon

Rowe

Santore

et al. 1984

Journal of Pharmaceutical Sciences

View full text Add to dashboard Cite

Section: Aspergillus Niger Trichoderma Viride Myrothecium Verrucarimentioning

confidence: 99%

Antifungal properties of 2-n-Alkyn-1-ols

Gershon

Rowe

Santore

et al. 1984

Journal of Pharmaceutical Sciences

View full text Add to dashboard Cite

“…Changes in the immunity of the patients, diabetes, and hormonal status can promote the onset of infection. Among the antifungal agents currently available to treat mucosal candidiasis are Tioconazole (TIO) and Econazole nitrate (ECO) both belonging to the azole family [3]. Azole agents have a common mechanism of action which is based on interfering with biosynthesis of ergosterol and thereby altering the normal functions of the cell membrane, causing cell death [4,5].…”

Section: Introductionmentioning

confidence: 99%

Design and Characterization of Chitosan Nanoformulations for the Delivery of Antifungal Agents

Calvo

Sreekumar

Svetaz

et al. 2019

IJMS

View full text Add to dashboard Cite

Among different Candida species triggering vaginal candidiasis, Candida albicans is the most predominant yeast. It is commonly treated using azole drugs such as Tioconazole (TIO) and Econazole (ECO). However, their low water solubility may affect their therapeutic efficiency. Therefore, the aim of this research was to produce a novel chitosan nanocapsule based delivery system comprising of TIO or ECO and to study their suitability in vaginal application. These systems were characterized by their physicochemical properties, encapsulation efficiency, in vitro release, storage stability, cytotoxicity, and in vitro biological activity. Both nanocapsules loaded with TIO (average hydrodynamic size of 146.8 ± 0.8 nm, zeta potential of +24.7 ± 1.1 mV) or ECO (average hydrodynamic size of 127.1 ± 1.5 nm, zeta potential of +33.0 ± 1.0 mV) showed excellent association efficiency (99% for TIO and 87% for ECO). The analysis of size, polydispersity index, and zeta potential of the systems at 4, 25, and 37 °C (over a period of two months) showed the stability of the systems. Finally, the developed nanosystems presented fungicidal activity against C. albicans at non-toxic concentrations (studied on model human skin cells). The results obtained from this study are the first step in the development of a pharmaceutical dosage form suitable for the treatment of vaginal candidiasis.

show abstract

Mitochondrial resistance to miconazole in Saccharomyces cerevisiae

Portillo

Gancedo

1985

Mol Gen Genet

View full text Add to dashboard Cite

One mutant of mitochondrial origin resistant to miconazole has been isolated and characterized in S. cerevisiae. The mutation is linked to the locus oli1, the structural gene for subunit 9 of ATPase on mitochondrial DNA. Miconazole inhibited the mitochondrial ATPase of the wild type while the enzyme of the resistant mutant was insensitive to this effect. Levels of ATP decreased to one-third of the control in the wild type in the presence of miconazole, while they were unaffected in the mutant.

show abstract

Chapter 15. Antifungal Chemotherapy

Cited by 5 publications

References 71 publications

Antifungal properties of 2-n-Alkyn-1-ols

Antifungal properties of 2-n-Alkyn-1-ols

Design and Characterization of Chitosan Nanoformulations for the Delivery of Antifungal Agents

Mitochondrial resistance to miconazole in Saccharomyces cerevisiae

Contact Info

Product

Resources

About