Chapter 19 The Role of Collagen in Peripheral Nerve Repair

Tocotrienol alleviates inflammation and oxidative stress in a rat model of spinal cord injury via suppression of transforming growth factor-β

“…SCI can directly cause necrosis and apoptosis of vascular endothelial cells, basement membrane components and structural damage of the microvascular wall, which are contributed to the disruption of the blood-spinal cord barrier and lead to the leakage of vascular material, and further aggravate the inflammatory reaction, edema and other secondary injury (40). As the basement membrane component, collagen IV and laminin begin degradation following spinal cord injury; however, the secretion of collagen IV and laminin are enhanced accordingly as the mechanism of vascular regeneration is activated rapidly by pathophysiological requirements (41).…”

“…As the basement membrane component, collagen IV and laminin begin degradation following spinal cord injury; however, the secretion of collagen IV and laminin are enhanced accordingly as the mechanism of vascular regeneration is activated rapidly by pathophysiological requirements (41). Previous results have shown that the early formation of collagen IV and laminin after spinal cord injury contribute to the restriction of inflammatory reaction and the promotion of neovascularization (40,41). Furthermore, pretreatment with tocotrienol treatment significantly reduced the protein expression of fibronectin in SCI rats, in the present study.…”

Advances in Nerve Guidance Conduit-Based Therapeutics for Peripheral Nerve Repair

“…As such, collagen is biodegradable, biocompatible, and immunologically inert for many applications [31][32][33] . In peripheral nerves, collagen plays a role in the maintenance of the basement membrane, which is synthesized and regulated by Schwann cells 34 . (Fig.…”

Bioactive Nanomaterials for Neural Engineering

“…Laminin has also been shown to have a critical effect on myelination during peripheral nerve regeneration in culture systems (Tsiper and Yurchenco 2002 ). As another basal lamina element, collagen is the major ECM protein and it is produced mostly by the fi broblasts and Schwann cells in fi brillary and nonfi brillar forms (Koopmans et al 2009 ). Fibrous types of collagens: collagen I, III, and V are found in all three ensheathing layers of peripheral nerve tissue.…”

“…Schwann cells also produce a more glycosylated and nonfi brillar type of collagen, collagen IV, which is a principle component of basal lamina. Collagen IV has a role in integrating laminin, perlecan, nidogen, and other ECM proteins into a supramolecular structure (Hudson et al 1993 ) in the basal lamina surrounding Schwann cells, the perineurial cells, and endoneurial capillaries (Koopmans et al 2009 ). Fibroblasts produce a fi brillary network of collagens and provide the framework required for Schwann cell ensheathment of regenerating axons (Eather et al 1986 ).…”