Chapter 20 The Imidazole Alkaloids

Battersby, Alan R.; Openshaw, Harry

doi:10.1016/s1876-0813(08)60142-6

Cited by 8 publications

(2 citation statements)

References 81 publications

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“…The "jaborandi" alkaloids are mainly of the imidazole group and it is thought that L-histidine is the biosynthetic precursor of the imidazole moiety (Battersby, Openshaw, 1953;Brochmann-Hanssen et al, 1975;Cordell, 1981;Dewick, 2000).…”

Section: Secondary Metabolites Of Pilocarpus Spp Alkaloidsmentioning

confidence: 99%

Pilocarpus spp.: a survey of its chemical constituents and biological activities

Santos¹,

Moreno²

2004

Rev. Bras. Cienc. Farm.

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Pilocarpus species have been exploited as the only source of the imidazole alkaloid pilocarpine (used in glaucoma treatment), since its isolation up to the present. Almost all Pilocarpus species are native from Brazil. Because of the medicinal importance of pilocarpine, several of them are in the path of extinction. Other secondary metabolites, such as coumarins, flavonoids and terpenes, were described for Pilocarpus species. In this review the secondary metabolites, other than pilocarpine, isolated from Pilocarpus species and their biological activities were compiled. Although the variety of structures and the importance of the biological activities described in literature for Pilocarpus species this is an unexploited field of research in Natural Products and Pharmacology.

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Section: Secondary Metabolites Of Pilocarpus Spp Alkaloidsmentioning

confidence: 99%

Pilocarpus spp.: a survey of its chemical constituents and biological activities

Santos¹,

Moreno²

2004

Rev. Bras. Cienc. Farm.

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“…A derrubada das plantas obriga os coletores a tirar folhas de plantas jovens, o que, a médio prazo, tem provocado a diminuição do teor de pilocapina (PHYTOSUL 14 1990). Assim, considerando os teores médios de alcalóides totais por safra, a zona litorânea baixou de 0,6%-0,7% para 0,4%-0,5% e na região de Barra do Corda, de 1,1% para 0,8% (PHYTOSUL 15 , 1990) (Figura 1).…”

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Estudo quimico e farmacologico de alcaloide secundario de Pilocarpus microphyllus Stapf

MariaRochadeAlbuquerqueLucio¹

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Über die Synthese der Pilocarpus‐Alkaloide Isopilosin und Pilocarpin, sowie die absolute Konfiguration des (+)‐Isopilosins

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Bernauer

1972

Helvetica Chimica Acta

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Soci6t6 suisse de chimie, B&le -Societ& svizzera di chimica, Basilea Nachdruck verboten -Tous droits rCservCs -Printed by Birkhauser AG., Basel, Switzerland Summary.A novel synthesis for rac-pilosinine (6 rac) and transformation of ( + )-pilosinine (6) into the pilocarpus alkaloids (+)-isopilosine (9) and (+)-pilocarpine (15) are described. By correlation via 6 with 15 the absolute configuration of (+)-isopilosinc (9) is established.Von den funf aus Pilocarpus-Arten isolierten Imidazol-Alkaloiden l), die teils der cis-Reihe, teils der thermodynamisch stabileren trms-(= iso-) 2)-

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Chapter 20 The Imidazole Alkaloids

Cited by 8 publications

References 81 publications

Pilocarpus spp.: a survey of its chemical constituents and biological activities

Pilocarpus spp.: a survey of its chemical constituents and biological activities

Estudo quimico e farmacologico de alcaloide secundario de Pilocarpus microphyllus Stapf

Über die Synthese der Pilocarpus‐Alkaloide Isopilosin und Pilocarpin, sowie die absolute Konfiguration des (+)‐Isopilosins

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