Chapter 32 Recalcitrant Wound

George, Zenas; Tolentino, Miguel; Lyons, Joseph

doi:10.1201/9781315364827-33

Cited by 3 publications

(4 citation statements)

References 32 publications

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“…There was no difference in the metabolic inhibition for all irradiation times tested. This finding is due to the fact that 40 minutes post irradiation was previously identified as the peak time post‐irradiation for change in mitochondrial metabolism .…”

Section: Resultsmentioning

confidence: 82%

“…In the present study, mitochondrial metabolism measured using the MTS assay was significantly lower for all irradiated groups compared to controls. These data were based on the addition of the MTS solution at 40 minutes post‐irradiation which has been previously identified as the peak time for change in mitochondrial metabolism . Previously, Chow et al (2007) examined mitochondrial membrane potential in DRG neurons treated with 830 nm wavelength light with an irradiance of 300 mW/cm 2 for 30 seconds.…”

Section: Discussionmentioning

confidence: 99%

“…Forty minutes after laser irradiation, MTS solution was added to each well. Forty minutes were chosen based on reports in the literature and previous work in our laboratory that identified that the peak time post‐irradiation for change in mitochondrial metabolism was 40 minutes . After incubation for 1.5 hour at 37°C, the supernatant was read for absorbance at 485 nm using FLUOstar OPTIMA plate reader (BMG Labtech, Inc., Cary, NC).…”

Section: Methodsmentioning

confidence: 99%

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The Mechanistic Basis for Photobiomodulation Therapy of Neuropathic Pain by Near Infrared Laser Light

Holanda

Chavantes

et al. 2018

Arq Bras Neurocir

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These in vitro and in vivo studies indicate that treatment with an irradiance/fluence rate at 270 mW/cm or higher at the level of the nerve can rapidly block pain transmission. A combination therapy is proposed to treat neuropathic pain with initial high irradiance/fluence rates for fast pain relief, followed by low irradiance/fluence rates for prolonged pain relief by altering chronic inflammation. Lasers Surg. Med. 49:516-524, 2017. © 2017 Wiley Periodicals, Inc.

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Section: Resultsmentioning

confidence: 82%

Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

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The Mechanistic Basis for Photobiomodulation Therapy of Neuropathic Pain by Near Infrared Laser Light

Holanda

Chavantes

et al. 2018

Arq Bras Neurocir

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“…For both oral cancer treatment and diabetic wound repairs, flexible QLED light source is expected to greatly simplify the light source setup, lower the overall treatment cost, and enhance quality of life of patients. 16,17…”

Section: Flexible Qleds For Treatment Of Two Specific Diseases: Diamentioning

confidence: 99%

Flexible quantum dot light‐emitting devices for targeted photomedical applications

Chen

Yeh

et al. 2018

J Soc Info Display

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Quantum dot light-emitting devices (QLEDs), originally developed for displays, were recently demonstrated to be promising light sources for various photomedical applications, including photodynamic therapy cancer cell treatment and photobimodulation cell metabolism enhancement. With exceptional emission wavelength tunability and potential flexibility, QLEDs could enable wearable, targeted photomedicine with maximized absorption of different medical photosensitizers. In this paper, we report, for the first time, the in vitro study to demonstrate that QLEDs-based photodynamic therapy can effectively kill Methicillin-resistant Staphylococcus aureus, an antibiotic-resistant bacterium. We then present successful synthesis of highly efficient quantum dots with narrow spectra and specific peak wavelengths to match the absorption peaks of different photosensitizers for targeted photomedicine. Flexible QLEDs with a peak external quantum efficiency of 8.2% and a luminance of over 20,000 cd/m2 at a low driving voltage of 6 V were achieved. The tunable, flexible QLEDs could be employed for oral cancer treatment or diabetic wound repairs in the near future. These results represent one fresh stride toward realizing QLEDs’ long-term goal to enable the wide clinical adoption of photomedicine.

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Quantum dot light emitting devices for photomedical applications

Chen

Lanzafame

et al. 2017

J Soc Info Display

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While OLEDs have struggled to find a niche lighting application that can fully take advantage of their unique form factors as thin, flexible, lightweight and uniformly large-area luminaire, photomedical researchers have been in search of low-cost, effective illumination devices with such form factors that could facilitate widespread clinical applications of photodynamic therapy (PDT) or photobiomodulation (PBM). Although existing OLEDs with either fluorescent or phosphorescent emitters cannot achieve the required high power density at the right wavelength windows for photomedicine, the recently developed ultrabright and efficient deep red quantum dot light emitting devices (QLEDs) can nicely fit into this niche. Here, we report for the first time the in-vitro study to demonstrate that this QLED-based photomedical approach could increase cell metabolism over control systems for PBM and kill cancerous cells efficiently for PDT. The perspective of developing wavelength-specific, flexible QLEDs for two critical photomedical fields (wound repair and cancer treatment) will be presented with their potential impacts summarized. The work promises to generate flexible QLED-based light sources that could enable the widespread use and clinical acceptance of photomedical strategies including PDT and PBM.

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Chapter 32 Recalcitrant Wound

Cited by 3 publications

References 32 publications

The Mechanistic Basis for Photobiomodulation Therapy of Neuropathic Pain by Near Infrared Laser Light

The Mechanistic Basis for Photobiomodulation Therapy of Neuropathic Pain by Near Infrared Laser Light

Flexible quantum dot light‐emitting devices for targeted photomedical applications

Quantum dot light emitting devices for photomedical applications

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