Chapter 34: Repellents for mosquito-borne disease control: beyond the repellency effect

Mulatier, Margaux; Cohuet, Anna; Carrasco, Davíd

doi:10.3920/978-90-8686-932-9_34

Cited by 5 publications

(2 citation statements)

References 186 publications

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“…Tese problems may lead to renewed malaria outbreaks and deaths from insecticidal poisoning. Above all, the situation is worsening in developing countries as the control of malaria vectors predominantly relies on these insecticide-based methods and due to the improper use of personal protection [6,7].…”

Section: Introductionmentioning

confidence: 99%

Larvicidal, Ovicidal, and Repellent Activities of Leucas stachydiformis (Hochst. ex Benth.) Briq Essential Oil against Anopheles arabiensis

Fikru,

Tolossa,

Lindemann

et al. 2024

Journal of Tropical Medicine

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Larvicidal, ovicidal, and repellent activities of the essential oil extracted by hydrodistillation from the leaves of the endemic Ethiopian plant Leucas stachydiformis (Hochst. ex Benth.) Briq were investigated against Anopheles arabiensis, the dominant malaria vector species in Ethiopia with the objective of searching for a plant-based malaria vector control strategy from medicinal plants. The larvicidal effect was tested against the fourth instar An. arabiensis wild larvae whilst freshly laid ova of An. arabiensis were used to determine the ovicidal activity of the essential oil at concentrations ranging from 6.25 to 400 ppm. Concentrations of 41.6–366.7 µg/cm2 were used to evaluate the repellent activity of the essential oil on 3–5 days old adult female An. arabiensis. The oil composition of L. stachydiformis was also analyzed using GC-MS. The study revealed that the oil possesses the highest larvicidal activity at 400 ppm and 200 ppm after 24 h and 48 h of treatment. LC50 values for the fourth larval instar after 24 h and 48 h of treatment were 43.4 ppm and 34.2 ppm, respectively. After 72 h of exposure, the oil displayed 100% ovicidal activity at 400 ppm with an IH50 value of 32.2 ppm. In the repellency test, at concentrations of 366.7, 133.3, and 41.6 µg/cm2, the oil gave a total percentage protection of 67.9 ± 4.2%, 37.2 ± 2.8%, and 32 ± 2.2%, respectively, for 4 h. The highest concentration (366.7 µg/cm2) gave 100% protection up to 90 min. GC-MS analysis of the oil revealed the presence of 24 compounds representing 90.34% of the total oil with caryophyllene oxide, germacrene D, and trans-caryophyllene constituting more than 50% of its components. Results of the present study suggest that the essential oil of L. stachydiformis has the potential to be used for the control of An. arabiensis mosquitoes.

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Section: Introductionmentioning

confidence: 99%

Larvicidal, Ovicidal, and Repellent Activities of Leucas stachydiformis (Hochst. ex Benth.) Briq Essential Oil against Anopheles arabiensis

Fikru,

Tolossa,

Lindemann

et al. 2024

Journal of Tropical Medicine

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“…aegypti sensory neuron enabling some of these sensory neurons to respond to multiple olfactory cues 12 . It is foreseen that "push-pull" strategies similar to those applied to agricultural pests 15 could be useful to control mosquitoes by pushing them away with environmental repellents and attracting them to deadly baits or traps 16 . Dengue and malaria vector control interventions targeting the chemosensory system through attractive toxic sugar baits (ATSB) can potentially reduce transmission by reducing feeding rates 17,18 .…”

mentioning

confidence: 99%

Automated analysis of feeding behaviors of females of the mosquito Aedes aegypti using a modified flyPAD system

Henriques-Santos,

Xiong,

Pietrantonio

2023

Sci Rep

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Mosquitoes present a global health challenge due to their ability to transmit human and animal pathogens upon biting and blood feeding. The investigation of tastants detected by mosquitoes and their associated feeding behaviors is needed to answer physiological and ecological questions that could lead to novel control methods. A high-throughput system originally developed for research in fruit flies feeding behavior, the flyPAD, was adapted and tested for behaviors associated with the interaction or consumption of liquid diets offered to females of the mosquito Aedes aegypti Liverpool strain. Females were given water, sucrose solution and sheep blood in choice and non-choice assays. The volume ingested was evaluated with fluorescein. The placement of the system on a heated surface allowed blood consumption, and without females puncturing a membrane. The flyPAD system recorded nine feeding behavioral variables, of which the number of sips and number of activity bouts correlated with meal volume ingested for both sucrose solution and blood. The adaptation to mosquitoes of the flyPAD system differentiated feeding behavior variables between two feeding deterrents, capsaicin, and caffeine. The flyPAD has potential to quickly assess diverse tastants in both sucrose and blood and may contribute to characterizing more precisely their mode of action.

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Larvicidal, Ovicidal and Repellent Activities of Leucas stachydiformis (Hochst. ex Benth.) Briq Essential Oil against Anopheles arabiensis

Fikru,

Tolossa,

Lindemann

et al. 2023

Preprint

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Background: Despite tremendous efforts made to curb malaria morbidity and mortality, malaria control has slowed down due to resistance to all currently used insecticides by mosquitoes, and their negative effect on the non-target organisms and the ecosystem. Thus, there is an urgent need to search and develop new plant-based malaria vector control strategy from medicinal plants origin such as essential oil. Methods: Larvicidal effect was tested against the fourth instar An. arabiensis wild larvae whilst freshly laid ova of An. arabiensis were used to determine ovicidal activity of the essential oil at concentrations ranging from 6.25 to 400 ppm. Concentrations of 41.6–366.7 µg/cm2 were used to evaluate repellent activity of the essential oil on 3–5 days old adult female An. Arabiensis. The essential oil composition of Leucas stachydiformis was also analyzed using GC-MS. Results: Larvicidal, ovicidal and repellent activities of the essential oil extracted by hydrodistillation from leaves of the endemic Ethiopian plant Leucas stachydiformis (Hochst. ex Benth.) Briq was investigated against Anopheles arabiensis, the dominant malaria vector species in Ethiopia. The study revealed that the oil possesses the highest larvicidal activity at 400 ppm and 200 ppm after 24 h and 48 h treatment. LC50 values for the fourth larval instar after 24 h and 48 h treatment were 43.4 ppm and 34.2 ppm, respectively. After 72 h exposure, the oil displayed 100% ovicidal activity at 400 ppm with IH50 value of 32.2 ppm. In the repellency test, at concentrations of 366.7, 133.3 and 41.6 µg/cm2, the oil gave total percentage protection of 67.9 ± 4.2%, 37.2 ± 2.8% and 32 ± 2.2%, respectively, for 4 hours. The highest concentration (366.7 µg/cm2) gave 100% protection up to 90 min. GC-MS analyses of the oil revealed the presence of 24 compounds representing 90.34% of the total oil with caryophyllene oxide, germacrene D, and trans-caryophyllene constituting more than 50% of its components. Conclusion: Results of the present study suggest that the essential oil of L. stachydiformis has the potential to be used for the control of An. arabiensis mosquitos.

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Chapter 34: Repellents for mosquito-borne disease control: beyond the repellency effect

Cited by 5 publications

References 186 publications

Larvicidal, Ovicidal, and Repellent Activities of Leucas stachydiformis (Hochst. ex Benth.) Briq Essential Oil against Anopheles arabiensis

Larvicidal, Ovicidal, and Repellent Activities of Leucas stachydiformis (Hochst. ex Benth.) Briq Essential Oil against Anopheles arabiensis

Automated analysis of feeding behaviors of females of the mosquito Aedes aegypti using a modified flyPAD system

Larvicidal, Ovicidal and Repellent Activities of Leucas stachydiformis (Hochst. ex Benth.) Briq Essential Oil against Anopheles arabiensis

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