Chapter 4 Transdifferentiated Hepatocytes in Rat Pancreas

Ms, Rao; Dg, Scarpelli; Jk, Reddy

doi:10.1016/s0070-2153(08)60654-7

Cited by 31 publications

(11 citation statements)

References 29 publications

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“…In experiments designed to determine the carcinogenic effects of repeated exposure to CdCl 2 , Fischer and Wistar rats showed a very high incidence of dose-related pancreatic metaplasia, as reflected by pancreatic hepatocyte formation (Konishi et al 1990). These pancreatic hepatocytes are thought to arise from the ductal and interstitial cells of the pancreas, which resemble oval cells of the liver (Rao et al 1986). Cadmium may activate oncogenes such as c- myc , mdm2 , and cellular tumor antigen p53 ; inhibit tumor suppressor genes such as wild-type p53 and p27 ; and consequently promote the proliferation of initiated cells (Fang et al 2002).…”

Section: Discussionmentioning

confidence: 99%

Serum Cadmium Levels in Pancreatic Cancer Patients from the East Nile Delta Region of Egypt

Kriegel

Soliman

Zhang

et al. 2006

Environ Health Perspect

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The northeast Nile Delta region exhibits a high incidence of early-onset pancreatic cancer. It is well documented that this region has one of the highest levels of pollution in Egypt. Epidemiologic studies have suggested that cadmium, a prevalent pollutant in the northeast Nile Delta region, plays a role in the development of pancreatic cancer.Objective: We aimed to assess serum cadmium levels as markers of exposure in pancreatic cancer patients and noncancer comparison subjects from the same region in Egypt.Design and Participants: We assessed serum cadmium levels of 31 newly diagnosed pancreatic cancer patients and 52 hospital comparison subjects from Mansoura, Egypt.Evaluation/Measurements: Serum cadmium levels were measured using a novel immunoassay procedure.Results: We found a significant difference between the mean serum cadmium levels in patients versus comparison subjects (mean ± SD, 11.1 ± 7.7 ng/mL vs. 7.1 ± 5.0 ng/mL, respectively; p = 0.012) but not in age, sex, residence, occupation, or smoking status. The odds ratio (OR) for pancreatic cancer risk was significant for serum cadmium level [OR = 1.12; 95% confidence interval (CI), 1.04–1.23; p = 0.0089] and farming (OR = 3.25; 95% CI, 1.03–11.64; p = 0.0475) but not for age, sex, residence, or smoking status.Conclusions: The results from this pilot study suggest that pancreatic cancer in the East Nile Delta region is significantly associated with high levels of serum cadmium and farming.Relevance to Clinical Practice/Public Health: Future studies should further investigate the etiologic relationship between cadmium exposure and pancreatic carcinogenesis in cadmium-exposed populations.

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Section: Discussionmentioning

confidence: 99%

Serum Cadmium Levels in Pancreatic Cancer Patients from the East Nile Delta Region of Egypt

Kriegel

Soliman

Zhang

et al. 2006

Environ Health Perspect

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“…Among pancreatic malignancies, AFP has been demonstrated in pancreatoblastomas [1,22] and ACCs [8,12,14,20], but rarely in other tumours [10]. Experimentally Rao et al [27] induced the appearance of hepatocyte-like cells (pancreatic hepatocytes) in the rat pancreas. In the human pancreas and its neoplasms, however, such hepatocyte-like cells have yet not been described.…”

Section: Discussionmentioning

confidence: 99%

Alpha fetoprotein-producing acinar cell carcinoma of the pancreas showing multiple lines of differentiation

Shinagawa

Tadokoro

Maeyama

et al. 1995

Vichows Archiv A Pathol Anat

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An alpha fetoprotein (AFP)-producing tumour occurring in the head of the pancreas of a 30-year-old woman is reported. Histological examination revealed a markedly solid proliferation of tumour cells with prominent nucleoli and occasional luminal structures, some of which contained mucinous material stained with mucicarmine and alcian blue. No squamoid corpuscles were recognized. Immunohistochemistry showed intense positivity for lipase trypsin, and AFP basically, and single cells were also positive for carcino-embryonic antigen, CA19-9, synaptophysin and neuron-specific enolase. Pancreatic hormone-positive cells were absent. Electron microscopical examination revealed numerous granules of variable sizes in the tumour cells, which were considered to be zymogen. The tumour is an acinar cell carcinoma with multi-directional differentiation including the ability to produce AFP. Among AFP-positive pancreatic tumours, acinar cell carcinoma and pancreatoblastoma seem to be the most frequent.

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“…The transdifferentiation of rat pancreatic acinar cells into hepatocytes also falls into this category, since this is a conversion between two cell types that originate from embryonic endoderm. This remarkable change is effectively induced by injection of various chemicals, including peroxisome proliferators, into adult rats in vivo (22,23). In this case, an in vitro experimental system has not yet been established.…”

Section: Transdiferentiation Between Cell Types Belonging To the Samementioning

confidence: 99%

Transdifferentiation in Animal Cells: Fact or Artifact?

Okada

1986

Dev Growth Differ

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Some specialized animal cells can overtly change from one differentiated phenotype to another through the process of transdifferentiation. In this review article, representative and convincing examples of transdifferentiation in cells of various animals ranging from mammals to coelenterates are presented. Several basic nature of the cellular properties that underly the transdifferentiation process is discussed. Studies are in progress to understand the mechanism of transdifferentiation in terms of gene expression.

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Chapter 4 Transdifferentiated Hepatocytes in Rat Pancreas

Cited by 31 publications

References 29 publications

Serum Cadmium Levels in Pancreatic Cancer Patients from the East Nile Delta Region of Egypt

Serum Cadmium Levels in Pancreatic Cancer Patients from the East Nile Delta Region of Egypt

Alpha fetoprotein-producing acinar cell carcinoma of the pancreas showing multiple lines of differentiation

Transdifferentiation in Animal Cells: Fact or Artifact?

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