Chapter 5 Oxide Bioceramics: Inert Ceramic Materials in Medicine and Dentistry

Li, J.; Hastings, G.W.

doi:10.1007/978-1-4939-3305-1_21

Cited by 15 publications

(4 citation statements)

References 25 publications

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“…Conditioned medium from UHMWPE particle-challenged hOBs has been shown to induce large numbers of multinucleated TRAP-positive giant cells from PBMCs at day 7 post-challenge in vitro (Granchi et al, 2004(Granchi et al, , 2005. These studies have also reported that, in contrast, Al 2 O 3 particles are less active in the induction of osteoclastogenesis (Li and Hastings, 2016), supporting the inert biological behavior of ceramic biomaterials.…”

Section: Osteoblast-osteoclast Interactionmentioning

confidence: 64%

The Effects of Biomaterial Implant Wear Debris on Osteoblasts

Zhang

Haddouti

Welle

et al. 2020

Front. Cell Dev. Biol.

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Aseptic loosening subsequent to periprosthetic osteolysis is the leading cause for the revision of arthroplasty failure. The biological response of macrophages to wear debris has been well established, however, the equilibrium of bone remodeling is not only dictated by osteoclastic bone resorption but also by osteoblast-mediated bone formation. Increasing evidence shows that wear debris significantly impair osteoblastic physiology and subsequent bone formation. In the present review, we update the current state of knowledge regarding the effect of biomaterial implant wear debris on osteoblasts. The interaction of osteoblasts with osteoclasts and macrophages under wear debris challenge, and potential treatment options targeting osteoblasts are also presented.

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Section: Osteoblast-osteoclast Interactionmentioning

confidence: 64%

The Effects of Biomaterial Implant Wear Debris on Osteoblasts

Zhang

Haddouti

Welle

et al. 2020

Front. Cell Dev. Biol.

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“…However, both materials have hardness 9 on the Mohs scale, making standard machining of SWS challenging [19,20]. They are also chemically inert and therefore chemical etching is not efficient [21,22].…”

Section: Introductionmentioning

confidence: 99%

Picosecond Laser Ablation of Millimeter-Wave Subwavelength Structures on Alumina and Sapphire

Wen,

Fadeeva,

Hanany

et al. 2021

Preprint

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We use a 1030 nm laser with 7 ps pulse duration and average power up to 100 W to ablate pyramid-shape subwavelength structures (SWS) on alumina and sapphire. The SWS give an effective and cryogenically robust anti-reflection coating in the millimeter-wave band. We demonstrate average ablation rate of up to 34 mm 3 /min and 20 mm 3 /min for structure heights of 900 µm and 750 µm on alumina and sapphire, respectively. These rates are a factor of 34 and 9 higher than reported previously on similar structures. We propose a model that relates structure height to cumulative laser fluence. The model depends on the absorption length δ, which is assumed to depend on peak fluence, and on the threshold fluence φ th . Using a best-fit procedure we find an average δ = 630 nm and 650 nm, and φ th = 2.0 +0.5 −0.5 J/cm 2 and 2.3 +0.1 −0.1 J/cm 2 for alumina and sapphire, respectively, for peak fluence values between 30 and 70 J/cm 2 . With the best fit values, the model and data values for cumulative fluence agree to within 10%. Given inputs for δ and φ th the model is used to predict average ablation rates as a function of SWS height and average laser power.

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“…Their biological properties are accompanied by high strength as well as superior corrosion and wear resistance. To date, alumina bioceramics have been successfully applied in load-bearing hip prosthesis, knee joints, bone screws, and middle-ear implants. − In addition, alumina in a single crystalline form has been identified as a promising candidate for dental, orthopedic, and neuroprostheses applications . Cytocompatibility of single crystalline alumina has been reported for several cell types including mouse cell lines, human oral epithelial cells, and fibroblasts. , Kawahara et al.…”

Section: Introductionmentioning

confidence: 99%

Toward Innovative Hemocompatible Surfaces: Crystallographic Plane Impact on Platelet Activation

Parlak

Labude

Rütten

et al. 2020

ACS Biomater. Sci. Eng.

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The anticoagulation treatment of cardiovascular patients, which is mandatory after implantation of heart valves or stents, has significantly adverse effects on life quality. This treatment can be reduced or even circumvented by developing novel antithrombogenic surfaces of blood-contacting implants. Thus, we aim to discover materials exhibiting outstanding hemocompatibility compared to other available synthetic materials. We present promising surficial characteristics of single crystalline alumina in terms of platelet activation inhibition. In order to elucidate the relation between its crystallographic properties including the plane orientation and blood cell behavior, we examined endothelialization, cytocompatibility, and platelet activation at the blood-alumina interfaces in a controlled experimental setup. We observed that the cell response is highly sensitive to the plane orientation and differs significantly for (0001) and (11–20) planes of Al2O3. Our results reveal for the first time the dependence of platelet activation on crystallographic orientation, which is assumed to be a critical condition controlling the thrombogenicity. Additionally, we used an endothelial cell monolayer as an internal control since endothelial cells have an impact on vessel integrity and implant acceptance. We successfully demonstrate that Al2O3(11–20) exhibits enhanced hemocompatibility in contrast to Al2O3(0001) and is comparable to the physiological endothelial monolayer in vitro.

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Chapter 5 Oxide Bioceramics: Inert Ceramic Materials in Medicine and Dentistry

Cited by 15 publications

References 25 publications

The Effects of Biomaterial Implant Wear Debris on Osteoblasts

The Effects of Biomaterial Implant Wear Debris on Osteoblasts

Picosecond Laser Ablation of Millimeter-Wave Subwavelength Structures on Alumina and Sapphire

Toward Innovative Hemocompatible Surfaces: Crystallographic Plane Impact on Platelet Activation

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