Chapter 5 The chick/quail transplantation model to study central nervous system development

Alvarado‐Mallart, Rosa‐Magda

doi:10.1016/s0079-6123(00)27006-4

Cited by 17 publications

(15 citation statements)

References 138 publications

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“…Similarly, it is not clear that the isthmic organizer has a substantial role in pretectal inner regionalization (although it evidently intervenes in establishing the DMB; Matsunaga et al, 2000; Vieira et al, 2006). Grafting of isthmic tissue or an Fgf8‐impregnated vehicle in the rostral midbrain, the prospective pretectum, or the thalamus has only resulted so far in induction of ectopic caudal midbrain, isthmic, and/or cerebellar structures, although finer analysis of such experiments perhaps might detect changes in pretectal anteroposterior regionalization (Martínez et al, 1991, 1999; Marin and Puelles, 1994; Bloch‐Gallego et al, 1996; Crossley et al, 1996; Wassef and Joyner, 1997; Alvarado‐Mallart, 2000; Vieira et al, 2006). There is the theoretical possibility that AP regionalization of the pretectum depends on alternative signaling centers formed either at the p1/p2 boundary, or at the DMB limit, or at both loci.…”

Section: Discussionmentioning

confidence: 99%

A model of early molecular regionalization in the chicken embryonic pretectum

Ferrán

Sánchez-Arrones

Sandoval

et al. 2007

J of Comparative Neurology

215

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The pretectal region of the brain is visualized as a dorsal region of prosomere 1 in the caudal diencephalon, including derivatives from both the roof and alar plates. Its neuronal derivatives in the adult brain are known as pretectal nuclei. The literature is inconsistent about the precise anteroposterior delimitation of this region and on the number of specific histogenetic domains and subdomains that it contains. We performed a cross-correlated gene-expression map of this brain area in chicken embryos, with the aim of identifying differently fated pretectal domains on the basis of combinatorial gene expression patterns. We examined in detail Pax3, Pax6, Pax7, Tcf4, Meis1, Meis2, Nkx2.2, Lim1, Dmbx1, Dbx1, Six3, FoxP2, Zic1, Ebf1, and Shh mRNA expression, as well as PAX3 and PAX7 immunoreaction, between stages HH11 and HH28. The patterns analyzed serve to fix the cephalic and caudal boundaries of the pretectum and to define three molecularly distinct anteroposterior pretectal domains (precommissural, juxtacommissural, and commissural) and several dorsoventral subdomains. These molecular specification patterns are established step by step between stages HH10 and HH18, largely before neurogenesis begins. This set of gene-architectonic data constitutes a useful scaffold for correlations with fate maps and other experimental embryologic results and may serve as well for inquiries on homologies in this part of the brain.

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Section: Discussionmentioning

confidence: 99%

A model of early molecular regionalization in the chicken embryonic pretectum

Ferrán

Sánchez-Arrones

Sandoval

et al. 2007

J of Comparative Neurology

215

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“…Indeed, the multilayered tectal structure, which represents the largest alar formation in the optic lobe, develops still farther along the rostral area of influence of the isthmic organizer (Marín and Puelles, 1994;Crossley et al, 1996a;Alvarado-Mallart, 2000;Martínez, 2001;Nakamura, 2001). Moreover, at the extreme rostral end of the midbrain alar plate, neural structure again displays a sudden coherent change extending radially from ventricular zone to pia, with the appearance of the griseum tectale (GT; Fig.…”

Section: Caudal Midbrain and Preisthmic Domainmentioning

confidence: 99%

A distinct preisthmic histogenetic domain is defined by overlap of Otx2 and Pax2 gene expression in the avian caudal midbrain

Hidalgo‐Sánchez

Martı́nez-de-la-Torre

Alvarado‐Mallart

et al. 2005

J of Comparative Neurology

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Correlative in situ hybridization of Otx2, Pax2, Gbx2, and Fgf8 mRNA probes in adjacent serial sections through the chicken midbrain and isthmus at early to intermediate stages of development served to map in detail the area of overlap of Otx2 and Pax2 transcripts in the caudal midbrain. The neuronal populations developing within this preisthmic domain made up a caudal part of the midbrain reticular formation, the interfascicular nucleus, and the magnocellular (pre)isthmic nucleus, plus the corresponding part of the periaqueductal gray. The torus semicircularis-the inferior colliculus homolog-expressed Otx2 in its ventricular lining exclusively, but it never expressed Pax2. The parvicellular isthmic nucleus, although placed inside the midbrain lobe, never expressed Otx2, and its cells rapidly down-regulated an early transient Pax2 signal; this pattern is consistent with its reported isthmic origin and forward tangential translocation. This analysis reveals the existence of four distinct midbrain histogenetic domains along the longitudinal axis, at least for the alar plate. These presumably result from step-like isthmic organizer effects on Otx2-expressing midbrain neuroepithelium at different distances from a caudal FGF8 morphogen source (isthmic Fgf8-positive domain). The final phenotypes of these domains are histologically diverse and make up the griseum tectale (rostrally), the optic tectum, the torus semicircularis, and the presently characterized preisthmic domain (lying closest to the isthmic organizer). Available comparative data for reptiles and mammals suggest the general validity of this scheme.

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“…So, studies of neuropotency are limited at present to the transplantation of cells derived from freshly isolated tissue that contains only a minor population of stem cells, or to cultured stem cells expanded using growth factors in vitro. Several excellent reviews have summarized the recent transplant literature [25][26][27][28][29][30] , so only a few points will be drawn out here.…”

Section: Embryonic Stem Cells Are Highly Neuropotentmentioning

confidence: 99%

Stem cell plasticity — building the brain of our dreams

Temple

2001

Nat Rev Neurosci

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Chapter 5 The chick/quail transplantation model to study central nervous system development

Cited by 17 publications

References 138 publications

A model of early molecular regionalization in the chicken embryonic pretectum

A model of early molecular regionalization in the chicken embryonic pretectum

A distinct preisthmic histogenetic domain is defined by overlap of Otx2 and Pax2 gene expression in the avian caudal midbrain

Stem cell plasticity — building the brain of our dreams

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