The recorded Cenozoic history of the Mojave Desert region of southern California began in the latest Oligocene, when intense volcanism and tectonism interrupted a long early Tertiary silence. Volcanism commenced across the region in an east-west band ca. 24-22 Ma. Northwest of Barstow, volcanism was accompanied by intense crustal extension and development of a metamorphic core complex. Outside of this relatively restricted area, extension was minor or absent. After extension ceased ca. 18 Ma, volcanism shifted to small-volume eruptions of basalt. Post-extensional deformation has largely been by strike-slip faulting along northwest-striking dextral faults and west-striking sinistral faults, and total dextral slip across the Mojave Desert region since the early Miocene is ϳ45-60 km. Strike-slip deformation has been overprinted locally by intense north-south contraction that is the dominant style of deformation in the western Mojave block.Paleomagnetic data indicate that parts of the Mojave block were rotated clockwise, although the magnitude and timing of this rotation are poorly determined. The best evidence for large (Ͼ45Њ) rotation comes from the area east of Barstow, where large clockwise declination anomalies and Mesozoic and Cenozoic dikes with anomalous strikes may reflect early Miocene clockwise deflection along the Mojave River fault.Volcanism and tectonism in the Mojave block resulted from interactions among the North American, Pacific, and various oceanic plates. Patterns of volcanism and tectonism do not correlate with growth of slab windows beneath the continent, but do correlate with the position of the subducted Mendocino fracture zone. Plate-circuit reconstructions suggest that the driving force for extension was divergence between the Pacific and North American plates along the transform margin that separated the two. This hypothesis accounts for the direction, magnitude, and rate of extension in the Mojave block.