Characterisation and Skin Distribution of Lecithin-Based Coenzyme Q10-Loaded Lipid Nanocapsules

Zhou, Haofei; Yang, Yue; Liu, Guanlan; Li, Yan; Zhang, Jing; Yan, Zemin; Duan, Mingxing

doi:10.1007/s11671-010-9677-z

Cited by 25 publications

(10 citation statements)

References 50 publications

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“…[20] Particle size and polydispersity index of LNC are affected by several factors such as proportions of the constituents, viscosity of the lipid phase, and production conditions. [21] In this study, the effects of lipid and vitamin D 3 percentage on the average particle size of LNCs were investigated. As Table 3 revealed, all the prepared LNC have the mean particle size distribution in the range of 31.43-36.66 nm.…”

Section: Particle Size Analysesmentioning

confidence: 99%

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Production of novel vitamin D₃ loaded lipid nanocapsules for milk fortification

Kiani

Fathi

Ghasemi

2017

International Journal of Food Properties

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Lipid nanoparticles are carriers to improve stability, solubility, and efficacy of bioactive compounds. In this paper, novel vitamin D 3 loaded lipid nanocapsules (LNC) were produced by phase inversion method. The produced nanocapsules were characterised by particle size, polydispersity index, zeta potential, encapsulation efficiency, and encapsulation load. LNC showed sizes in the range of 31.43 to 36.66 nm. Optimum LNC formulation was selected for further analysis (such as morphological study, analysis of chemical structure, release study, and sensory evaluation). Transmission electron microscopy revealed that particles had approximately spherical shape. The Fourier transform infrared spectra indicated that no adverse reactions occurred between vitamin D 3 and lipid nanocapsules. About 9.6% of vitamin released in gastric simulated solution (pH: 1.2), which indicated that LNC can protect vitamin against acidic conditions. Sensory evaluation revealed the potential application of produced vitamin D 3 loaded LNC for development of fortified milk.

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Section: Particle Size Analysesmentioning

confidence: 99%

“…[21] It is an important and useful indicator to predict physical stability of colloidal systems. This factor even influences the release kinetic and the biological fate of nanoparticles.…”

Section: Zeta Potentialmentioning

confidence: 99%

Production of novel vitamin D₃ loaded lipid nanocapsules for milk fortification

Kiani

Fathi

Ghasemi

2017

International Journal of Food Properties

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“…It is known that small size ensures close contact with the stratum corneum and can increase the amount of drug absorbed by the skin (12). Zhaou et al (30) reported that Q10 loaded lipid nanocapsules accumulated in both epidermis and dermis. Since oxidative stress affects several pathways, the delivery of Q10 into the skin is particularly important (31).…”

Section: Resultsmentioning

confidence: 99%

Development and evaluation of coenzyme Q10 loaded solid lipid nanoparticle hydrogel for enhanced dermal delivery

Korkm¹,

Gökçe²,

Özer³

2013

Acta Pharmaceutica

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Skin is the protective organ of the body with an area around 2 m 2 . The hazardous potential of toxins, pathogens and UV radiation are avoided by the protection that skin supplies (1). UV radiation is the main source of energy that initiates reactive oxygen species (ROS). Formation of ROS leads to oxidative damage in DNA, proteins and lipids. The skin has an enzymatic (superoxide dismutase, catalase, and glutathione peroxidase) and non-enzymatic (antioxidant) protection mechanism against these damages; however, excess ROS production overcomes this protection and causes several diseases such as cancer (2, 3). Hence, effective delivery of an antioxidant into skin in required levels is an important challenge. There are two main steps limiting the effective delivery antioxidants, oxidation of the active substance and carrying the active substance to the viable epidermis.Antioxidants are defined as substances that, when present in a low concentration compared to that of oxidizable substrates, significantly delay or inhibit oxidation of that substance (4). In general, antioxidants act by the chain breaking reaction, by reducing the concentration of reactive oxygen species, by scavenging initiating radicals and by chelating transition metal catalysts (5). Coenzyme Q10 (Q10) is the only lipid soluble endogenous antioxidant. It supports ATP generation during aerobic cellular respiration in the electron transport chain in the mitochondria and inhibits cell membrane peroxidation in reduced form (6, 7). However, it is very difficult to prepare a formulation that helps Q10 delivery to deeper layers of the skin due to the low aqueous solubility of Q10 (log P >10) and due to the barrier function of stratum corneum (8).In the second half of the nineties there was an increasing interest in investigating solid lipid nanoparticles (SLNs) for dermal application. SLNs have many advantages, especially for dermal applications such as occlusion, modulation of drug release and penetration into the skin (9). Since they are made from solid lipids, chemically unstable lipid soluble compounds that are sensitive to oxidation can be successfully encapsulated in the SLNs (8, 10). Several molecules were incorporated into lipid nanoparticles, e.g., ascorbyl palmitate, resveratrol, retinol and retinyl palmitate, vitamin E and vitamin E acetate (8,(11)(12)(13)(14). It has been shown that systemic uptake of active substances (e.g., isotretinoin) through skins could be avoided and SLN could increase the accumulative uptake of the active material in the skin (15). SLNs are produced as liquid dispersions and their incorporation into hydrogels or emulsions helps enhance the retention time in the applied area and patient compliance (16,17).Hydrogels are generally formed from carbomers that have the ability to absorb water, get hydrated and swell by neutralization with a base. Carbomers have been mainly used in liquid or semi-solid pharmaceutical formulations in order to modify their flow characteristics (17,18).The aim of this work was to carry an effic...

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“…It is a lipid-soluble provitamin with low solubility in aqueous solutions (logP > 10) [116]. Therefore, SLNs, liposomes and other formulations have been explored as drug delivery vehicles for Coenzyme Q10 to facilitate penetration into the deeper layers of skin [117].…”

Section: Topical Applications Of Nanoparticlesmentioning

confidence: 99%

Nanoparticles and nanofibers for topical drug delivery

Goyal

Macri

Kaplan

et al. 2016

Journal of Controlled Release

456

227

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This review provides the first comprehensive overview of the use of both nanoparticles and nanofibers for topical drug delivery. Researchers have explored the use of nanotechnology, specifically nanoparticles and nanofibers, as drug delivery systems for topical and transdermal applications. This approach employs increased drug concentration in the carrier, in order to increase drug flux into and through the skin. Both nanoparticles and nanofibers can be used to deliver hydrophobic and hydrophilic drugs and are capable of controlled release for a prolonged period of time. The examples presented provide significant evidence that this area of research has—and will continue to have — a profound impact on both clinical outcomes and the development of new products.

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Characterisation and Skin Distribution of Lecithin-Based Coenzyme Q10-Loaded Lipid Nanocapsules

Cited by 25 publications

References 50 publications

Production of novel vitamin D₃ loaded lipid nanocapsules for milk fortification

Production of novel vitamin D₃ loaded lipid nanocapsules for milk fortification

Development and evaluation of coenzyme Q10 loaded solid lipid nanoparticle hydrogel for enhanced dermal delivery

Nanoparticles and nanofibers for topical drug delivery

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Characterisation and Skin Distribution of Lecithin-Based Coenzyme Q10-Loaded Lipid Nanocapsules

Cited by 25 publications

References 50 publications

Production of novel vitamin D3 loaded lipid nanocapsules for milk fortification

Production of novel vitamin D3 loaded lipid nanocapsules for milk fortification

Development and evaluation of coenzyme Q10 loaded solid lipid nanoparticle hydrogel for enhanced dermal delivery

Nanoparticles and nanofibers for topical drug delivery

Contact Info

Product

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Production of novel vitamin D₃ loaded lipid nanocapsules for milk fortification

Production of novel vitamin D₃ loaded lipid nanocapsules for milk fortification