1992
DOI: 10.1002/jmv.1890380102
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Characterisation by restriction mapping of three subtypes of Molluscum contagiosum virus

Abstract: DNA from Molluscum contagiosum virus (MCV) isolates was analysed by restriction endonuclease digestion, identifying three virus subtypes. The structural features of MCV DNA are typical of poxviral DNA. Physical maps of cleavage sites for BamHI, CIaI, and HindIII were constructed for single isolates of each subtype. These differ extensively, indicating the independence of the three subtypes. However, they are closely related, as determined by molecular hybridisation and nucleotide sequence analysis, and their g… Show more

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Cited by 54 publications
(27 citation statements)
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“…There is considerable conserved genetic organization between MCV1 and MCV2. However, there is a 12 kilobase region unique to MCV1 and a 2-3 kilobase deletion in MCV2 (Porter and Archard, 1992). The significance of the variations between the subtypes is poorly understood.…”
Section: Discussionmentioning
confidence: 97%
“…There is considerable conserved genetic organization between MCV1 and MCV2. However, there is a 12 kilobase region unique to MCV1 and a 2-3 kilobase deletion in MCV2 (Porter and Archard, 1992). The significance of the variations between the subtypes is poorly understood.…”
Section: Discussionmentioning
confidence: 97%
“…The high-GC PCR assay amplified the clinical sample, and the sequences of the amplified amplicon identified it as a molluscum contagiosum-like virus (unpublished results). The MOCV has at least three subtypes (19), and the sequence of the amplicon derived from (Fig. 3B); this may indicate that it is another subtype.…”
Section: Vol 48 2010 Gc Content-based Pcr Assays To Identify Poxvirmentioning
confidence: 99%
“…The worldwide incidence is estimated to be between 2% and 8% 9 . There are four main subtypes of molluscum contagiosum: MCV I, MCV II, MCV III, and MCV IV 10,11 . All subtypes cause similar clinical lesions in genital and nongenital regions.…”
Section: Discussionmentioning
confidence: 99%