Characterisation, in vitro release study, and antibacterial activity of montmorillonite-gentamicin complex material

Formulation and antibacterial properties of clay mineral-tetracycline and -doxycycline composites

“…Their natural abundance and low toxicity has contributed to their widespread application and has made clay minerals popular materials for drug delivery research. An increasing body of research (Rodrigues et al, 2013;Viseras et al, 2010) is being published on the subject of using clay minerals to deliver a range of antibacterial molecules such as chlorhexidine (Samlíková et al, 2017), ciprofloxacin (Hamilton et al, 2014;Rivera et al, 2016), clindamycin (Porubcan et al, 1978), gentamicin (Rapacz-kmita et al, 2017), vancomycin (Pan et al, 2017), and ofloxacin (Wang et al, 2014), amongst others. The interaction between clay-minerals and drug-molecules is also reported to yield a controlled-release of the adsorbed drug molecules (Park et al, 2008;Rivera et al, 2016), which is attractive for many pharmaceutical applications including patients.…”

Study on montmorillonite–chlorhexidine acetate–terbinafine hydrochloride intercalation composites as drug release systems

“…20 A number of studies have focused on the interaction of guest molecules with clays including MMT. Rapacz-Kmita et al studied the synergistic antibacterial activity and slow drug release of montmorillonite and gentamicin; 21 Saha et al studied the inhibition of E. coli and S. aureus by chlorhexidine acetatemontmorillonite composites; 22 Ambrogi et al studied montmorillonite-chitosan-chlorhexidine intercalated lms with antimicrobial activity and improved toxicity for wound dressing. 23 These are all studies of antibacterial activity, but there is currently a lack of research on antifungals.…”

Preparation and in vitro evaluation of hydrophobic‐modified montmorillonite stabilized pickering emulsion for overdose acetaminophen removal

“…Montmorillonite, a kind of natural inorganic material, has been reported as a relatively efficient and safe detoxifying agent for removing toxic substances from a living organism . As an emulsifier, montmorillonite shows several distinctive advantages: (i) biocompatibility in pharmacy and environmental‐friendly properties, (ii) the proper adsorptivity, and (iii) effective adsorption with a few amount to the interface (relative to the spherical particles) …”