Characterisation of beam focus quality in biomedical nuclear microscopy: A Fourier optics approach

Advanced time-stamped total data acquisition control front-end for MeV ion beam microscopy and proton beam writing

“…1. In addition provision is made to control the lens current power supplies from the spare digital to analogue converters (DACs) to allow auto-focussing of the beam [5,6].…”

Investigation Of Multi-Resolution Support For MeV Ion Microscopy Imaging

“…The objective of this work was to investigate if a multi-resolution supported imaging strategy can be used to reduce the fluences needed for rapidly finding the field of view when using ion microprobes. This is particularly important when imaging biomedical specimens, where low-fluence techniques 6,7 are necessary to avoid detrimental ion induced changes in the specimen 8 . The work was motivated by the development of a new MeV ion microbeam (DREAM 9 ) at the Pelletron accelerator in Jyväskylä that will feature high speed post-focus scanning coupled with a new generation of data collection system that is based on time-stamping to facilitate onthe-fly image transformation in lateral as well as time dimensions.…”

Angular and lateral spreading of ion beams in biomedical nuclear microscopy

“…Recently, a number of NM sytems are being developed for in-situ cell imaging and single-cell irradiation studies where the beam passes through a 4-10 lm, or so thick vacuum-atmosphere window before entering the living cells [3]. The resolution in NM is governed by the point spread function (PSF) [4,5]. For imaging using a scanned beam, the PSF is the convolution of an extrinsic contribution from the beam spot profile [4], S(x, y), with an intrinsic contribution, Gðt; qÞ, that originates from the spatial spreading of the ion beam as it traverses the sample of thickness, t, (Fig.…”