Characterisation of ecto- and endoparasites in domestic cats from Tirana, Albania

Knaus, Martin; Rapti, Dhimitër; Shukullari, Enstela; Kusi, Ilir; Postoli, Rezart; Xhaxhiu, Dashamir; Silaghi, Cornelia; Hamel, Dietmar; Visser, Martin; Winter, Renate; Rehbein, Steffen

doi:10.1007/s00436-014-3999-1

Cited by 42 publications

(27 citation statements)

References 51 publications

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“…Indeed, kittens tend to be more often infected by protozoans (e.g., C. felis and G. lamblia) and ascarids (i.e., T. cati), than adult cats. This trend has been confirmed in studies on T. cati and C. felis, in which it has been shown that infected cats ≤9 months of age are at higher risk for those pathogens (Beugnet et al, 2014;Knaus et al, 2014b). Conversely, in the present study the age of animals was not a risk factor for lungworm infection, since either young or adult animals were infected by A. abstrusus or T. brevior.…”

Section: Discussionsupporting

confidence: 87%

Efficacy of Broadline® spot-on against Aelurostrongylus abstrusus and Troglostrongylus brevior lungworms in naturally infected cats from Italy

Giannelli

Brianti

Varcasia

et al. 2015

Veterinary Parasitology

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The increasing reports of Aelurostrongylus abstrusus infection and the new information on Troglostrongylus brevior have spurred the interest of the scientific community towards the research of pharmaceutical compounds effective against both pathogens. A novel topical combination of fipronil, (S)-methoprene, eprinomectin and praziquantel (Broadline®, Merial) has been released for the treatment of a variety of feline parasitic infections. The present study reports the efficacy of this spot-on in treating cats naturally infected by feline lungworms. Client owned cats (n=191) were enrolled from three geographical areas of Italy and faecal samples were examined by floatation and Baermann techniques. Twenty-three individuals were positive for L1 of A. abstrusus (n=18) or T. brevior (n=3) or for both species (n=2) and they were topically treated with Broadline®. Seventeen of them were also concomitantly infected by other parasites. Four weeks after treatment, faecal samples were collected and examined to assess the efficacy of a single administration of the product. Based on lungworm larvae counts, the efficacy of the treatment was 90.5% or 100% for A. abstrusus or T. brevior, respectively. Cats released significantly lower amounts of lungworm larvae after treatment compared to pre-treatment (p<0.0001). All but three cats were negative for other nematodes after treatment and all cats recovered from respiratory signs. Results of this study indicate that a single administration of the topical combination fipronil, (S)-methoprene, eprinomectin and praziquantel is effective and safe for the treatment of A. abstrusus and/or T. brevior infections in cats living under field conditions.

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Section: Discussionsupporting

confidence: 87%

Efficacy of Broadline® spot-on against Aelurostrongylus abstrusus and Troglostrongylus brevior lungworms in naturally infected cats from Italy

Giannelli

Brianti

Varcasia

et al. 2015

Veterinary Parasitology

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“…The results of this controlled study demonstrated that a single topical treatment with Broadline®, at the recommended dose, provided a high level of efficacy against feline Broadline® was shown to be effective against the two major nematodes parasitizing the respiratory system of domestic cats, A. abstrusus and C. aerophila, which are frequently associated as they may share similar paratenic hosts as suggested through co-occurrence in cats (Ng and Kelly 1975;Capári et al 2013;Knaus et al 2014b). A single treatment with Broadline® can reduce burdens of C. aerophila lungworms and markedly reduce or eliminate shedding of eggs.…”

Section: Discussionmentioning

confidence: 94%

Efficacy of Broadline® against Capillaria aerophila lungworm infection in cats

Knaus¹,

Shukullari

Rapti

et al. 2015

Parasitol Res

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Capillaria aerophila is a globally distributed parasite of the respiratory system of carnivores and can be considered the second most common lungworm after Aelurostrongylus abstrusus in domestic cats in the northern hemisphere. To evaluate the efficacy of Broadline (Merial), a combination of fipronil 8.3% w/v, (S)-methoprene 10% w/v, eprinomectin 0.4% w/v and praziquantel 8.3% w/v against C. aerophila, a controlled study with 20 naturally infected cats was conducted. Following blocking by body weight, cats were allocated randomly to two groups of ten animals each: control (untreated) or treated once with Broadline according to the label instructions. For evaluation of efficacy, faeces were examined for capillarid egg shedding prior to and weekly for 3 weeks after treatment, when the cats were necropsied for C. aerophila recovery. Following single topical administration of Broadline, faecal capillarid egg counts were significantly reduced by 93.5 to 99.1% (p < 0.01) compared to the controls. Cats treated harboured significantly fewer C. aerophila lungworms compared to the untreated controls (efficacy 82.4%, p = 0.016). Results of this study demonstrate that Capillaria lungworm burdens can be markedly reduced and that faecal egg shedding can be substantially lowered or eliminated following a single treatment with Broadline.

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“…However, factors like category of cats (e.g., stray, feral, shelter, cattery, well-cared-for pet), habitat (urban or rural), or general access to the outdoors, result in considerable variability in the prevalence of endoparasites (e.g., Borkovcová, 2003;Coati et al, 2003;Omeragić, 2003;Miró et al, 2004;Robben et al, 2004;Romaniuk et al, 2004;Ingstrup, 2008;Gracenea et al, 2009;Keidāns et al, 2009;Overgaauw et al, 2009;Duarte et al, 2010;Ładczuk and Balicka-Ramisz, 2010;Mircean et al, 2010;Traversa et al, 2010;Barutzki and Schaper, 2011;Claerebout et al, 2011;Knaus et al, 2011b;Becker et al, 2012;Mugnaini et al, 2012;Näreaho et al, 2012;Zanzani et al, 2012;Capári et al, 2013;Riggio et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

Efficacy against nematode and cestode infections and safety of a novel topical fipronil, (S)-methoprene, eprinomectin and praziquantel combination product in domestic cats under field conditions in Europe

Rehbein¹,

Capári²,

Duscher

et al. 2014

Veterinary Parasitology

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A novel topical combination product (BROADLINE(®), Merial) composed of fipronil, (S)-methoprene, eprinomectin and praziquantel was evaluated for safety and efficacy against nematode and cestode infections in domestic cats. The study comprised a multi-centre, positive control, blinded, field study, using a randomized block design based on order of presentation for allocation. In total 196 client-owned cats, confirmed as positive for naturally acquired infections of nematodes and/or cestodes by pre-treatment faecal examination, were studied in seven countries in Europe. Pre-treatment faecal examination revealed the presence of Toxocara, hookworm, Capillaria and/or spirurid nematode infections in 129, 73, 33 or 1 cat(s), respectively; infections with taeniid and Dipylidium cestodes were demonstrated in 39 and 17 cats, respectively. Cats were allocated randomly to one of two treatments in a ratio of 2, topical fipronil (8.3%, w/v), (S)-methoprene (10%, w/v), eprinomectin (0.4%, w/v) and praziquantel (8.3%, w/v) (BROADLINE(®), Merial; 130 cats); and 1, topical PROFENDER(®) Spot-On (Bayer; 66 cats) and treated once on Day 0. For evaluation of efficacy, two faecal samples were collected, one prior to treatment (Day -4 ± 4 days) and one at the end of the study (Day 14 ± 5 days). These were examined for fecal forms of nematode and cestode parasites. For evaluation of safety, cats were examined by a veterinarian before treatment and at the end of the study, and cat owners recorded the health status of their cats daily until the end of the study. For cats treated with Broadline(®), the efficacy was >99.9%, 100%, and 99.6% for Toxocara, hookworms, and Capillaria, respectively; and the efficacy was >99.9%, >99.9%, and 98.5%, respectively, for the cats treated with Profender(®) (p<0.001 for all nematodes and both treatments). Efficacy was 100% for both cestodes for both treatments (p<0.001). No treatment related adverse experiences were observed throughout the study. For both treatments, every cat that completed the study was given a safety score of 'excellent' for both local and systemic evaluations. The topical combination product of fipronil, (S)-methoprene, eprinomectin and praziquantel was shown to have an excellent safety profile and demonstrated high levels of efficacy when administered once as topical solution to cats infected with nematodes and cestodes under field conditions.

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Characterisation of ecto- and endoparasites in domestic cats from Tirana, Albania

Cited by 42 publications

References 51 publications

Efficacy of Broadline® spot-on against Aelurostrongylus abstrusus and Troglostrongylus brevior lungworms in naturally infected cats from Italy

Efficacy of Broadline® spot-on against Aelurostrongylus abstrusus and Troglostrongylus brevior lungworms in naturally infected cats from Italy

Efficacy of Broadline® against Capillaria aerophila lungworm infection in cats

Efficacy against nematode and cestode infections and safety of a novel topical fipronil, (S)-methoprene, eprinomectin and praziquantel combination product in domestic cats under field conditions in Europe

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