Characterisation of Ga2O3–Na2O–CaO–ZnO–SiO2 bioactive glasses

Wren, A.W.; Keenan, Timothy J.; Coughlan, A.; Laffir, Fathima; Boyd, Daniel; Towler, Mark R.; Hall, M. M.

doi:10.1007/s10853-013-7211-2

Cited by 22 publications

(24 citation statements)

References 35 publications

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“…Gallium (Ga) is a known chemotherapeutic ion and its biological function has been approved by food and drug administration (FDA) [12,13]. It is also accepted that Ga prevents osteoclast bone resorption by increasing calcium (Ca) concentration without influencing osteoblasts [14].…”

Section: Introductionmentioning

confidence: 99%

Fabrication and characterization of poly(octanediol citrate)/gallium-containing bioglass microcomposite scaffolds

et al. 2014

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Bone can be affected by osteosarcomae requiring surgical excision of the tumor as part of the treatment regime. Complete removal of cancerous cells is difficult and conventionally requires the removal of a margin of safety around the tumor to offer improved patient prognosis. This work considers a novel series of composite scaffolds based on poly(octanediol citrate) (POC) impregnated with galliumbased bioglass microparticles for possible incorporation into bone following tumor removal. The objective of this research was to fabricate and characterize these scaffolds and subsequently report on their mechanical and biological properties. The porous microcomposite scaffolds with various concentrations of bioglass (10, 20, 30 wt%) incorporated were fabricated using a salt leaching technique. The scaffolds exhibited compression modulus in the range of 0.3-7 MPa. The addition of bioglass increased the mechanical properties even though porosity increased. Furthermore, increasing the concentration of bioglass had a significant influence on glass transition temperature from 2.5°C for the pure polymer to around 25°C for 30 % bioglass-containing composite. The ion release study revealed that composites containing 10 % bioglass had the highest ion release ratio after 28 days of soaking in phosphate buffered saline. The interaction of bioglass phase with POC led to the formation of additional ionic crosslinks aside from covalent crosslinks which further resulted in increased stiffness and decreased weight loss. The osteoblast cells were well attached and growth on composites and collagen synthesis increased particularly with the 10 % bioglass concentration.

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Section: Introductionmentioning

confidence: 99%

Fabrication and characterization of poly(octanediol citrate)/gallium-containing bioglass microcomposite scaffolds

et al. 2014

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“…Therefore, their chemistry gives them the potential for use in a range of orthopedic applications [17] including vertebroplasty and kyphoplasty. GPCs are both biocompatible and bioactive [18,19,20,21,22,23,24,25,26], but the presence of aluminum (Al 3+ ) in the glass phase of GPCs has restricted their use in orthopedics due to both its influence on bone mineralization [27,28] and its associated involvement in the pathogenesis of degenerative brain diseases [21,29,30]. It was reported by Carter et al [31] that the glass composition can be modified by incorporating ions which have a positive therapeutic effect upon release from the cement.…”

Section: Introductionmentioning

confidence: 99%

A Novel Glass Polyalkenoate Cement for Fixation and Stabilisation of the Ribcage, Post Sternotomy Surgery: An ex-Vivo Study

Alhalawani

Curran

Pingguan‐Murphy

et al. 2013

JFB

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This study investigates the use of gallium (Ga) based glass polyalkenoate cements (GPCs) as a possible alternative adhesive in sternal fixation, post sternotomy surgery. The glass series consists of a Control (CaO–ZnO–SiO2), and LGa-1 and LGa-2 which contain Ga at the expense of zinc (Zn) in 0.08 mol% increments. The additions of Ga resulted in increased working time (75 s to 137 s) and setting time (113 to 254 s). Fourier Transform Infrared (FTIR) analysis indicated that this was a direct result of increased unreacted poly(acrylic acid) (PAA) and the reduction of crosslink formation during cement maturation. LGa samples (0.16 wt % Ga) resulted in an altered ion release profile, particularly for 30 days analysis, with maximum Ca2+, Zn2+, Si4+ and Ga3+ ions released into the distilled water. The additions of Ga resulted in increased roughness and decreased contact angles during cement maturation. The presence of Ga has a positive effect on the compressive strength of the samples with strengths increasing over 10 MPa at 7 days analysis compared to the 1 day results. The additions of Ga had relatively no effect on the flexural strength. Tensile testing of bovine sterna proved that the LGa samples (0.16 wt % Ga) are comparable to the Control samples.

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“…The common cation charge of Y is Y 3+ , and Ce is also found as Ce 3+ , analogous to that of both Al +3 and Ga 3+ which have been found to act as network intermediates depending on the ratio to Si and charge compensating cations [43,44]. Ce is also found as Ce 4+ , and while similar in charge to Si, it is nearly double the ionic size in addition to having a typical coordination environment greater than 4 as…”

Section: Discussionmentioning

confidence: 84%

Characterization of Y2O3 and CeO2 doped SiO2-SrO-Na2O glasses

Placek¹,

Keenan²,

Laffir³

et al. 2015

Biomedical Glasses

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Abstract:The structural effects of yttrium (Y) and cerium (Ce) are investigated when substituted for sodium (Na) in a 0.52SiO 2 -0.24SrO-(0.24−x)Na 2 O-xMO (where x = 0.08; MO = Y 2 O 3 and CeO 2 ) glass series. Network connectivity (NC) was calculated assuming both Y and Ce can act as a network modifier (NC = 2.2) or as a network former (NC up to 2.9). Thermal analysis showed an increase in glass transition temperature (Tg) with increasing Y and Ce content, Y causing the greater increase from the control (Con) at 493 ∘ C to 8 mol% Y (HY) at 660 ∘ C. Vickers hardness (HV)was not significantly different between glasses. 29 Si MagicAngle Spinning-Nuclear Magnetic Resonance (MAS-NMR) did not show peak shift with addition of Y, however Ce produced peak broadening and a negative shift in ppm. The addition of 4 mol% Ce in the YCe and LCe glasses shifted the peak from Con at −81.3 ppm to −82.8 ppm and −82.7 ppm respectively; while the HCe glass produced a much broader peak and a shift to −84.8 ppm. High resolution X-ray Photoelectron Spectroscopy for the O 1s spectral line showed the ratio of bridging (BO) to non-bridging oxygens (NBO), BO:NBO, was altered, where Con had a ratio of 0.7, HY decreased to 0.4 and HCe to 0.5.

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Characterisation of Ga2O3–Na2O–CaO–ZnO–SiO2 bioactive glasses

Cited by 22 publications

References 35 publications

Fabrication and characterization of poly(octanediol citrate)/gallium-containing bioglass microcomposite scaffolds

Fabrication and characterization of poly(octanediol citrate)/gallium-containing bioglass microcomposite scaffolds

A Novel Glass Polyalkenoate Cement for Fixation and Stabilisation of the Ribcage, Post Sternotomy Surgery: An ex-Vivo Study

Characterization of Y2O3 and CeO2 doped SiO2-SrO-Na2O glasses

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