Characterisation of Gallstones Using Fourier Transform Infrared Spectroscopy

Ravichandran, G.; Lakshiminarayanan, G.; Gopinath, D.; Arumugam, S.

doi:10.9790/4861-0904021018

Cited by 2 publications

(4 citation statements)

References 8 publications

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“…And these findings are comparable to the studies conducted by Qiao et al, Nair et al, and Lamia et al5,11,12 100 out of 120 gallstones were mixed type of gallstones which was the maximum (83.3%) in this study population. The results are comparable to the studies conducted by Kleiner et al, Ravichandran et al, Raman et al and Ha et al2,4,8,13 Most of them were brown in colour followed by black.…”

supporting

confidence: 90%

“…Depending upon the external appearance and colour, gallstones were conventionally classified as cholesterol stones, pigmented (black/brown) stones and mixed stones. 2 In this study based on the chemical composition and inner morphology we classified the gallstones as mentioned earlier.…”

Section: Discussionmentioning

confidence: 99%

“…1 There has been a growing incidence of gallstone disease in recent years. 1 Gallstone formation is a slow process occurring over many years 2 ; monitoring their formation from nucleation to consolidation is quite difficult. Therefore, gallstone formation is very poorly understood.…”

Section: Introductionmentioning

confidence: 99%

“…The method is non-invasive, reagent-free, accurate and less time consuming. 2 The instrument is multipurpose and can therefore be used for gallstone analysis. Molecules in the gallstones provide a distinctive absorption spectrum in the infrared region, depending on the chemical bonding and the specific composition.…”

Section: Introductionmentioning

confidence: 99%

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An analytical study of gallstones by Fourier transform infrared spectroscopy technique

Bilagi

Godhi

2022

Int Surg J

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Background: Cholelithiasis continues to be a serious human health concern and presently cholecystectomy is the only adopted standard treatment option. Gallstones’ chemical structures differ in different demographic groups. Accurate analysis of the constituents of gallstones may help us to understand their etiopathogenesis. Fourier transform infrared spectroscope (FTIR) can identify the composition of gallstones by creating a spectrum of infrared absorption.Methods: A hospital based one year observational study was conducted in KLES’ Dr. Prabhakar Kore Hospital and Medical Research Centre, Belagavi and 120 gallstones were collected post laparoscopic/open cholecystectomy. After FTIR spectroscopic analysis gallstones were classified based on the FTIR spectrum peaks.Results: Cholesterol, bilirubin and calcium carbonate are the components identified based on the standard FTIR spectrum characteristics with cholesterol being the commonest followed by bilirubin. Brown colored stones were more common followed by black. We classified gallstones into 3 groups based on FTIR analysis as: pure cholesterol stones, pure bilirubin stones and mixed type of stones. Mixed type of gallstones containing cholesterol and bilirubin were more common.Conclusions: The study concludes cholelithiasis is common in females and in age group more than 40 years. Mixed types of gallstones are the commonest. Cholesterol followed by bilirubin are the major constituents of the gallstones.

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supporting

confidence: 90%

Section: Discussionmentioning

confidence: 99%