Characterisation of Homoflavonoids from Three <i>Ophioglossum</i> Species Using Liquid Chromatography with Diode Array Detection and Electrospray Ionisation Tandem Mass Spectrometry

Wan, Chuan‐Xing; Luo, Jian‐Guang; Gu, Yu‐Cheng; Xu, Defeng; Kong, Ling–Yi

doi:10.1002/pca.2430

Cited by 6 publications

(7 citation statements)

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“…Six homoflavonoids, ophioglonin, ophioglonin 7-O-β-Dglucopyranoside, ophioglonol, ophioglonol prenyl ether, ophioglonol 4′-O-β-D-glucopyranoside, and isoophioglonin 7-O-β-D-glucopyranoside, quercetin, luteolin, kaempferol, 3,5,7,3′,4′-pentahydroxy-8-prenylflavone, and quercetin 3-O-methyl ether, were isolated from O. petiolatum (Lin et al 2005a, b). Homoflavonoids were also found in O. vulgatum and O. thermale (Wan et al 2013). These compounds can be divided to two groups: type I homoflavonoids, which have an additional carbon atom attached to the C-3 position of ring C, and undergo competing losses of H 2 O and CH 2 O from their aglycone ions; and type II homoflavonoids, which bear an additional carbon atom at the C-2′ position of ring B, forming a new ring (Wan et al 2013;Lin et al 2005a, b;Wan et al 2012).…”

Section: Ophioglossaceaementioning

confidence: 90%

“…Homoflavonoids were also found in O. vulgatum and O. thermale (Wan et al 2013). These compounds can be divided to two groups: type I homoflavonoids, which have an additional carbon atom attached to the C-3 position of ring C, and undergo competing losses of H 2 O and CH 2 O from their aglycone ions; and type II homoflavonoids, which bear an additional carbon atom at the C-2′ position of ring B, forming a new ring (Wan et al 2013;Lin et al 2005a, b;Wan et al 2012).…”

Section: Ophioglossaceaementioning

confidence: 90%

“…Homoflavonoids from O. petiolatum have antihepatitis B virus activity (Lin et al 2005b;Wan et al 2013). O. pedunculosum contains 3-O-methylquercetin glucosides that inhibit lipopolysaccharideinduced NO production in macrophages (Wan et al 2012), and a mannan-specific lectin with antifungal activity (He et al 2011).…”

Section: Ophioglossaceaementioning

confidence: 99%

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Phytochemicals from fern species: potential for medicine applications

et al. 2017

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Ferns are an important phytogenetic bridge between lower and higher plants. Historically they have been used in many ways by humans, including as ornamental plants, domestic utensils, foods, and in handicrafts. In addition, they have found uses as medicinal herbs. Ferns produce a wide array of secondary metabolites endowed with different bioactivities that could potentially be useful in the treatment of many diseases. However, there is currently relatively little information in the literature on the phytochemicals present in ferns and their pharmacological applications, and the most recent review of the literature on the occurrence, chemotaxonomy and physiological activity of fern secondary metabolites was published over 20 years ago, by Soeder (Bot Rev 51:442–536, 1985). Here, we provide an updated review of this field, covering recent findings concerning the bioactive phytochemicals and pharmacology of fern species

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Section: Ophioglossaceaementioning

confidence: 90%

Section: Ophioglossaceaementioning

confidence: 90%

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Phytochemicals from fern species: potential for medicine applications

et al. 2017

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“…The commonest example in many forest states has been observed to be the Ophioglossum ( Figure 4 e) species on the ground and Marsilea spp ( Figure 4 f) from the aquatic ecosystem. Flavonoids were isolated from the aerial parts of the pteridophyte O. vulgatum ., including 3- O -methylquercetin and its glucosides, 5’-isoprenyl-3- O -ethylquercetin 4’,7-di-β- d -glucopyranoside, 3- O -methylquercetin 4’-β- d -glucopyranoside 7-[ O -β- d- glucopyranosyl-(1 → 2)-β- d -glucopyranoside [ 18 , 52 ]. Seven new homoflavonoid glucosides, pedunculosumosides A–G, were isolated from the ethanolic extracts of whole O .…”

Section: Methods: Field Work and Descriptionmentioning

confidence: 99%

“…Six homoflavonoids, ophioglonin, ophioglonin 7- O -β- d- glucopyranoside, ophioglonol, ophioglonol prenyl ether, ophioglonol 4’- O -β- d -glucopyranoside, and isoophioglonin 7- O -β- d -glucopyranoside, quercetin, luteolin, kaempferol and 3,5,7,3’,4’-pentahydroxy-8-prenylflavone etc. [ 18 , 52 ].…”

Section: Methods: Field Work and Descriptionmentioning

confidence: 99%

Ancient Food Habits Dictate that Food Can Be Medicine but Medicine Cannot Be “Food”!!

Goswami¹,

Ram²

2017

Medicines

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Background: Extensive surveys of several population settlements in different parts of India—covering plains, mountains, valleys, river banks and deeper areas of forests at different altitudes—between 1968 and 2016 demonstrated that the basic vital need of hunger is being fulfilled since antiquity by plants in the wild. Methods: Based on collections, consultations with local population personnel and literature searches, this paper presents many plants that are commonly used as food and focuses on their products, which are rich in alkaloids, polysaccharides, steroids, terpenoids, flavonoids, aminoacids, fatty acids and antibiotics etc. These complex organic compounds are suitable for the production of drugs for many ailments/diseases, including the prevention of cancers. Results: There are more than 100 families including several hundred plant taxa from various plant groups like angiosperms, bryophytes, pteridophytes, gymnosperms and even fleshy fungi, which have offered essential food items to ever-growing human populations since antiquity. Phytochemicals functioning as antioxidants are exceedingly beneficial to the human body but excess consumption of these compounds, adding higher levels of antioxidants, may even be responsible for chronic diseases including aging, cancer, cardiovascular diseases, rheumatoid arthritis, atherosclerosis, etc. These medicines can obviously be taken in small and prescribed quantities but can never be consumed as “food items.”

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Anti‐inflammatory properties of ophioglonin derived from the fern Ophioglossum vulgatum L. via inactivating NF‐κB and MAPK signaling pathways

Zhu,

Tian,

Yao

et al. 2024

FEBS Open Bio

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Medicinal plants contain bioactive compounds that have therapeutic effects on human health. Ophioglossum vulgatum L. is a representative species of the fern genus Ophioglossum that has anti‐inflammatory properties as recognized in folk medicine. Herein, we performed a nitric oxide (NO) assay‐guided screening in RAW264.7 cells to investigate the active components of the plant. We found that ophioglonin (OPN), a characteristic homoflavonoid of the genus Ophioglossum, is one of the bioactive components. Therefore, we performed a comparative analysis of the isolated compounds and found that OPN has effects similar to those of isolated dihydroquercetin and luteolin at the concentrations tested. The antioxidant and anti‐inflammatory activities of OPN were extensively validated using lipopolysaccharide ‐stimulated RAW264.7 cells, mouse bone marrow‐derived macrophages (BMDMs), and peritoneal exudate macrophages (PEMs). In vivo experiments with a carrageenan‐induced mouse paw edema model further confirmed the anti‐inflammatory effect of OPN. Additionally, we found that OPN and Ophioglossum vulgatum extracts inhibit the activation of signal transducers, NF‐ĸB p65, IĸBα, ERK, p38, and JNK, consistent with the findings of pathway enrichment analysis. This work reinforces the anti‐inflammatory properties of Ophioglossum vulgatum and indicates that OPN is a promising therapeutic agent for inflammation‐associated disorders. Further clinical evaluations, including clinical trials, would be beneficial to validate the anti‐inflammatory properties of OPN.

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Characterisation of Homoflavonoids from Three Ophioglossum Species Using Liquid Chromatography with Diode Array Detection and Electrospray Ionisation Tandem Mass Spectrometry

Abstract: The HPLC-DAD-ESI/MS(n) method obtained in the present study provided a powerful tool for identifying homoflavonoids from ferns in the genus Ophioglossum.

Cited by 6 publications

References 28 publications

Phytochemicals from fern species: potential for medicine applications

Phytochemicals from fern species: potential for medicine applications

Ancient Food Habits Dictate that Food Can Be Medicine but Medicine Cannot Be “Food”!!

Anti‐inflammatory properties of ophioglonin derived from the fern Ophioglossum vulgatum L. via inactivating NF‐κB and MAPK signaling pathways

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