Characterisation of the anti-inflammatory and antinociceptive activities and the mechanism of the action of Lippia gracilis essential oil

Guilhon, Carolina Carvalho; Raymundo, Larissa J.R.P.; Alviano, Daniela Sales; Blank, Arie Fitzgerald; Arrigoni-Blank, M.F.; Matheus, Maria Eline; Cavalcanti, Sócrates C.H.; Alviano, Celuta Sales; Fernandes, Patrícia Dias

doi:10.1016/j.jep.2011.03.032

Cited by 53 publications

(33 citation statements)

References 42 publications

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“…Apesar dos vários relatos na literatura sobre a importância medicinal, bioquímica e ornamental das diversas espécies do gênero Lippia (Compadre et al, 1986;Valentin et al, 1995;Pascual et al, 2001;Costa et al, 2002;Hennebelle et al, 2008;Guilhon et al, 2011), ainda há escassez de estudos direcionados à propagação vegetativa, especialmente quanto ao melhor tipo de propágulo e substrato para algumas espé-cies, como é o caso da L. gracilis.…”

Section: R G Santos Et Alunclassified

Tipo de estaca e substrato na propagação vegetativa de Lippia gracilis Schauer

et al. 2016

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RESUMO: Lippia gracilis é uma planta nativa da Caatinga, rica em óleo essencial com atividade antimicrobiana. O trabalho objetivou avaliar o efeito de diferentes tipos de estacas e substratos na propagação vegetativa de L. gracilis . O experimento foi montado em delineamento inteiramente casualizado, em esquema fatorial 3 x 3, sendo 3 tipos de estacas (apical, mediana e basal) e 3 tipos de substratos (areia + húmus, argila + húmus e areia + argila + húmus), com 5 repetições cada. Aos 40 dias foram avaliadas: porcentagem de estacas brotadas e enraizadas, número médio de brotos, comprimento da maior raiz e biomassa seca dos brotos e raízes. Em todas as variáveis as estacas medianas e basais apresentaram melhores resultados do que as apicais. O substrato influenciou apenas na biomassa seca dos brotos, sendo o composto de argila + húmus superior ao areia + argila + húmus e igual, em significância, ao areia+ húmus.

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Section: R G Santos Et Alunclassified

Tipo de estaca e substrato na propagação vegetativa de Lippia gracilis Schauer

et al. 2016

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“…Mice were used according to the method previously reported 42,43 . The doses and the routes of administration are provided in Section 2.5.1.…”

Section: Acetic Acid-induced Vascular Permeabilitymentioning

confidence: 99%

“…This test was performed in order to measure the latency of the response 42,43 . A glass cylinder was placed on a hotplate with adjustable temperature.…”

Section: Hot Plate Testmentioning

confidence: 99%

Anti-inflammatory, Antinociceptive Activity of an Essential Oil Recipe Consisting of the Supercritical Fluid CO2 Extract of White Pepper, Long Pepper, Cinnamon, Saffron and Myrrh in vivo

Zhang

Wang

et al. 2014

J. Oleo Sci.

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“…The nociceptive response in the acetic acid-induced abdominal constriction assay arises from synthesis of prostaglandins by the action of the constitutively expressed enzyme cyclooxygenase-2 (COX-2), which leads to hyperalgesia and pain (Berkenkopf and Weichmann 1988;Ballou et al 2000). Terpenes, the major constituent of BPEOs, possess numerous pharmacological and therapeutic properties and exert antinociceptive and anti-inflammatory effects (Mendes et al 2010;Guilhon et al 2011). Previous studies demonstrated analgesic activity for p-cymene (Illouz and Delbarre 1964;Duke et al 2002) and anti-inflammatory activity for γ-terpinene (Duke et al 2002;Milde et al 2004).…”

Section: Discussionmentioning

confidence: 99%

Antinociceptive mechanisms of Bunium persicum essential oil in the mouse writhing test: role of opioidergic and histaminergic systems

Zendehdel¹,

Torabi²,

Hassanpour³

2015

Vet. Med.

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Bunium persicum (Boiss.) is an economically important medicinal plant growing wildly in arid regions in Iran. The fruit of B. persicum is widely used in traditional Iranian medicine to control colic pain and dysmenorrhoea. The aim of the current study was to determine antinociceptive mechanisms of B. persicum essential oil using an acetic acid-induced writhing test as a model of visceral pain and to determine the possible involvement of opioidergic, serotoninergic and histaminergic systems on antinociceptive mechanisms of B. persicum in male mice. In experiment 1, B. persicum was intraperitoneally (i.p.) injected (0.001, 0.01, 0.05, 0.1, 0.5 and 1%; 10 ml/kg) in Tween-80 (0.5%) and a writhing test served as a model of visceral pain. In experiments 2-5, opioidergic receptor antagonist (naloxone, 2 mg/kg), serotonergic receptor antagonist (cyproheptadine, 4 mg/kg), histamine H 1 -receptor antagonist (chlorpheniramine, 20 mg/kg) and histamine H 2 -receptor antagonist (cimetidine, 12.5mg/kg) injection was followed by B. persicum (0.01%; 10 ml/kg) and the writhing test response was measured for 30 min. According to the results, essential oil of B. persicum, administered i.p. (0.001, 0.01, 0.05, 0.1, 0.5, and 1%; 10 ml/kg) in Tween-80 (0.5%), elicited antinociceptive effects in a dose-dependent manner. Moreover, the antinociceptive effect of B. persicum was significantly attenuated by pre-treatment with naloxone, chlorpheniramine and cimetidine (P < 0.001). These results suggest that B. persicum-induced analgesia may be mediated via opioidergic and histamine H 1 and H 2 receptors.

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Characterisation of the anti-inflammatory and antinociceptive activities and the mechanism of the action of Lippia gracilis essential oil

Cited by 53 publications

References 42 publications

Tipo de estaca e substrato na propagação vegetativa de Lippia gracilis Schauer

Tipo de estaca e substrato na propagação vegetativa de Lippia gracilis Schauer

Anti-inflammatory, Antinociceptive Activity of an Essential Oil Recipe Consisting of the Supercritical Fluid CO2 Extract of White Pepper, Long Pepper, Cinnamon, Saffron and Myrrh in vivo

Antinociceptive mechanisms of Bunium persicum essential oil in the mouse writhing test: role of opioidergic and histaminergic systems

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