Characterisation of the bioactive behaviour of sol–gel hydroxyapatite–CaO and hydroxyapatite–CaO–bioactive glass composites

Hatzistavrou, E.; Chatzistavrou, Xanthippi; Papadopoulou, Lambrini; Kantiranis, Nikolaos; Kontonasaki, Eleana; Boccaccını, Aldo R.; Paraskevopoulos, K. M.

doi:10.1016/j.msec.2010.01.009

Cited by 18 publications

(13 citation statements)

References 19 publications

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“…The characteristic peaks observed at 632 and 3571 cm −1 are attributable to the respective hydroxyl functional group (-OH) deformation vibration and stretching vibrations of HAp [ 22 ]. Additionally, a sharp peak was observed at 3642 cm −1 , which confirms the formation of the CaO phase [ 23 ].…”

Section: Resultsmentioning

confidence: 99%

Fabrication and Characteristics of Porous Hydroxyapatite-CaO Composite Nanofibers for Biomedical Applications

Tsai

Huang

et al. 2018

Nanomaterials

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Hydroxyapatite (HAp), a major inorganic and essential component of normal bone and teeth, is a promising biomaterial due to its excellent biocompatibility, bioactivity, and osteoconductivity. Therefore, synthetic HAp has been widely used as a bone substitute, cell carrier, and delivery carrier of therapeutic genes or drugs. Mesoporous materials have attracted considerable attention due to their relatively high surface area, large pore volume, high porosity, and tunable pore size. Recently, mesoporous HAp has also been successfully synthesized by the traditional template-based process and has been demonstrated to possess better drug-loading and release efficiencies than traditional HAp. It is widely accepted that cell adhesion and most cellular activities, including spreading, migration, proliferation, gene expression, surface antigen display, and cytoskeletal functioning, are sensitive to the topography and molecular composition of the matrix. The native extracellular matrix is a porous, nanofibrous structure. The major focus of this study is the fabrication of porous hydroxyapatite-CaO composite nanofibers (p-HApFs) and the investigation of its drug-release property. In this study, nanofibers were prepared by the sol-gel route and an electrospinning technique to mimic the three-dimensional structure of the natural extracellular matrix. We analyzed the components of fibers using X-ray diffraction and determined the morphology of fibers using scanning and transmission electron microscopy. The average diameter of the nanofibers was approximately 461 ± 186 nm. The N2 adsorption–desorption isotherms were type IV isotherms. Moreover, p-HApFs had better drug-loading efficiency and could retard the burst release of tetracycline and maintain antibacterial activity for a period of 7 days. Hence, p-HApFs have the potential to become a new bone graft material.

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Section: Resultsmentioning

confidence: 99%

Fabrication and Characteristics of Porous Hydroxyapatite-CaO Composite Nanofibers for Biomedical Applications

Tsai

Huang

et al. 2018

Nanomaterials

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“…The CAO stretching vibration of CO 3 2À appeared between 890 and 800 cm À1 and suggests the presence of carbonated Ca-P on the surface of the films. [1][2][3][4][5] The FTIR of PU/PVA blend had almost no change when compared to samples not immersed in SBF, showing that the polymer blend is not able to form an HA layer in this period. Figure 8 shows the SEM image of calcium phosphate layer formed on the surface of the composite with 10% BGNP after 7 days in SBF.…”

Section: Evaluation Ha Layer Depositionmentioning

confidence: 97%

“…In vitro bioactivity test The formation of a HA layer in vitro on a material surface is believed to indicate its bioactive potential in vivo. [1][2][3][4][5] Simulated body fluid (SBF) was prepared by Kokubo's protocol. 2 The formation of HA layer on the surface of obtained films was evaluated after soaking the samples in SBF solution for 7 days.…”

Section: Materials Characterizationmentioning

confidence: 99%

“…1,2 Furthermore, the dissolution products of bioactive glass exert control over genetic factors of bone growth. [3][4][5] Various investigations regarding sol-gelderived BG have been published including bulk and powder bioactive glasses 6,7 and porous bioactive glass scaffolds. [8][9][10] However, compared with natural bone tissue, bioactive glasses especially processed as foams, exhibit lower mechanical properties.…”

Section: Introductionmentioning

confidence: 99%

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Development of biodegradable polyurethane and bioactive glass nanoparticles scaffolds for bone tissue engineering applications

et al. 2012

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The development of polymer/bioactive glass has been recognized as a strategy to improve the mechanical behavior of bioactive glass-based materials. Several studies have reported systems based on bioactive glass/biopolymer composites. In this study, we developed a composite system based on bioactive glass nanoparticles (BGNP), obtained by a modified Stöber method. We also developed a new chemical route to obtain aqueous dispersive biodegradable polyurethane. The production of polyurethane/BGNP scaffolds intending to combine biocompatibility, mechanical, and physical properties in a material designed for tissue engineering applications. The composites obtained were characterized by structural, biological, and mechanical tests. The films presented 350% of deformation and the foams presented pore structure and mechanical properties adequate to support cell growth and proliferation. The materials presented good cell viability and hydroxyapatite layer formation upon immersion in simulated body fluid.

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“…The results showed that apatite was formed on the coating and there was a higher concentration of apatite formation in fractured areas ( Figure 4 ). According to Hatzistavrou et al, the rapid growth of the apatite on the surface of the samples can be associated with the presence of the CaO phase in the natural HA [ 25 ].…”

Section: Resultsmentioning

confidence: 99%

Development of HA/Ag-NPs Composite Coating from Green Process for Hip Applications

et al. 2017

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In the present study, biological hydroxyapatite (HA) was obtained from bovine bones through a thermal process. A total of 0% and 1% of silver nanoparticles (Ag-NPs) synthesized from Opuntia ficus (nopal) were added to the biological hydroxyapatite coatings using an atmospheric plasma spray (APS) on a Ti6Al4V substrate. Following this, its antimicrobial efficiency was evaluated against the following bacterial strains: Escherichia coli, Staphylococcus aureus, and Pseudomonas aeruginosa. This was conducted according to the Japanese Industrial Standard (JIS) Z2801:2000 “Antimicrobial Product-Test for Antimicrobial Activity and Efficacy”. Scanning electron microscopy (SEM) showed that the silver nanoparticles (Ag-NPs) were evenly distributed on the coating surface. Energy dispersive X-ray spectroscopy (EDX) shows that apatite deposition occurs on a daily basis, maintaining a Ca/P rate between 2.12 and 1.45. Biocompatibility properties were evaluated with osteoblast-like cells (MC3T3-E1) by single-cell gel electrophoresis assay and Tali image cytometry.

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Characterisation of the bioactive behaviour of sol–gel hydroxyapatite–CaO and hydroxyapatite–CaO–bioactive glass composites

Cited by 18 publications

References 19 publications

Fabrication and Characteristics of Porous Hydroxyapatite-CaO Composite Nanofibers for Biomedical Applications

Fabrication and Characteristics of Porous Hydroxyapatite-CaO Composite Nanofibers for Biomedical Applications

Development of biodegradable polyurethane and bioactive glass nanoparticles scaffolds for bone tissue engineering applications

Development of HA/Ag-NPs Composite Coating from Green Process for Hip Applications

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