Characterisation of wear debris from UHMWPE on zirconia ceramic, metal-on-metal and alumina ceramic-on-ceramic hip prostheses generated in a physiological anatomical hip joint simulator

Tipper, Joanne L.; Firkins, P; Besong, A A; Barbour, P.S.M.; Nevelos, Jim; Stone, Martin; Ingham, Eileen; Fisher, John

doi:10.1016/s0043-1648(01)00653-6

Cited by 120 publications

(88 citation statements)

References 35 publications

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“…4). The size of isolated individual particles from MOM bearings has been shown to be smaller than 100 nm [22,29]. The size of the clusters observed correlates with previous reports [21,30].…”

Section: Discussionsupporting

confidence: 87%

“…Cluster formation of metal particles was also reported by Doorn et al [21]. Particles isolated by lubricant digestion formed clumps in larger amount than particles isolated from distilled water [29]. The agglomeration of metal particles was also ascribed to an optical effect from multiple layers of small particles packed inside histiocytes [31].…”

Section: Discussionmentioning

confidence: 54%

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Wear debris from hip prostheses characterized by electron imaging

Topolovec

Milošev²,

Cör³

et al. 2013

Open Medicine

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AbstractThe characterization of wear particles is of great importance in understanding the mechanisms of osteolysis. In this unique study, thirty-one tissue samples were retrieved at revision surgeries of hip implants and divided into four groups according to the composition of metal prosthetic components. Tissue samples were first analyzed histologically and then by scanning electron microscopy (SEM) combined with back-scattered electron imaging and energy dispersive X-ray spectroscopy. Therefore, particles were studied directly in situ in tissue sections, without the requirement for particle isolation. The composition of metal wear particles detected in the tissue sections corresponded to the composition of the implant components. A considerable number of large metal particles were actually clusters of submicron particles. The clustering of submicron particles was observed primarily with CoCrMo (cobalt-chromiummolybdenum) and, to a lesser extent, for stainless steel particles. SEM secondary and back-scattered electron imaging was an appropriate and selective method for recognizing the composition of metal particles in the in situ tissue sections, without destroying their spatial relationship within the histology. This method can be used as a screening tool for composition of metal and ceramic particles in tissue sections, or as an additional method for particle identification.

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Section: Discussionsupporting

confidence: 87%

Section: Discussionmentioning

confidence: 54%

Wear debris from hip prostheses characterized by electron imaging

Topolovec

Milošev²,

Cör³

et al. 2013

Open Medicine

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“…Strategies to reduce wear have focused on improvements of the bearing surface, including the use of enhanced polyethylene and the introduction of alternative bearings such as metal-on-metal and ceramics. In vitro testing has confirmed ceramic-on-ceramic bearings have the lowest wear rates of all tested couples [26] and would seem best suited to the high-activity patient in whom long-term wear is a concern.…”

Section: Introductionmentioning

confidence: 91%

Ceramic-on-Ceramic Total Hip Arthroplasty: Incidence of Instability and Noise

Schroder

Bornstein

Bostrom

et al. 2011

Clinical Orthopaedics &Amp; Related Research

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Background Alternative bearing materials in THA have been developed to reduce the incidence of osteolysis. Alumina-on-alumina bearings exhibit extremely low wear rates in vitro, but concerns exist regarding component impingement with the potential for dislocation and the occurrence of noise. Questions/purposes We determined generation of squeaking and the relationship between squeaking and component position. Methods We prospectively entered 436 alumina-on-alumina, cementless, primary THAs in 364 patients into our institutional database. All procedures were performed with the same surgical technique and the same implant. We obtained Harris Hip scores and a noise questionnaire and assessed radiographic component position and loosening. We determined the difference in abduction angle between squeakers and nonsqueakers. Minimum followup was 2 years (average, 3.5 years; range, 2.0-6.2 years).

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“…The CoCrMo and Ti-6Al-4V particles used in this study were similar in size and shape to those retrieved from periprosthetic tissues and those generated by physiological hip simulators [19,24,[44][45][46]. The size and shape of CoCrMo and Ti-6Al-4V particles showed slight variation between the validation study [34] and the rat study.…”

Section: Discussionmentioning

confidence: 61%

Recovery of low volumes of wear debris from rat stifle joint tissues using a novel particle isolation method

et al. 2018

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a b s t r a c t Less than optimal particle isolation techniques have impeded analysis of orthopaedic wear debris in vivo. The purpose of this research was to develop and test an improved method for particle isolation from tissue. A volume of 0.018 mm 3 of clinically relevant CoCrMo, Ti-6Al-4V or Si 3 N 4 particles was injected into rat stifle joints for seven days of in vivo exposure. Following sacrifice, particles were located within tissues using histology. The particles were recovered by enzymatic digestion of periarticular tissue with papain and proteinase K, followed by ultracentrifugation using a sodium polytungstate density gradient. Particles were recovered from all samples, observed using SEM and the particle composition was verified using EDX, which demonstrated that all isolated particles were free from contamination. Particle size, aspect ratio and circularity were measured using image analysis software. There were no significant changes to the measured parameters of CoCrMo or Si 3 N 4 particles before and after the recovery process (KS tests, p > 0.05). Titanium particles were too few before and after isolation to analyse statistically, though size and morphologies were similar. Overall the method demonstrated a significant improvement to current particle isolation methods from tissue in terms of sensitivity and efficacy at removal of protein, and has the potential to be used for the isolation of ultra-low wearing total joint replacement materials from periprosthetic tissues. Statement of SignificanceThis research presents a novel method for the isolation of wear particles from tissue. Methodology outlined in this work would be a valuable resource for future researchers wishing to isolate particles from tissues, either as part of preclinical testing, or from explants from patients for diagnostic purposes. It is increasingly recognised that analysis of wear particles is critical to evaluating the safety of an orthopaedic device.

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Characterisation of wear debris from UHMWPE on zirconia ceramic, metal-on-metal and alumina ceramic-on-ceramic hip prostheses generated in a physiological anatomical hip joint simulator

Cited by 120 publications

References 35 publications

Wear debris from hip prostheses characterized by electron imaging

Wear debris from hip prostheses characterized by electron imaging

Ceramic-on-Ceramic Total Hip Arthroplasty: Incidence of Instability and Noise

Recovery of low volumes of wear debris from rat stifle joint tissues using a novel particle isolation method

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