Characteristic modifications of magnesium and its alloy for future implant material - Review

Afandi, Ridwan; Sutiyoko,; Lutiyatmi,

doi:10.1088/1742-6596/1517/1/012061

Cited by 2 publications

(2 citation statements)

References 35 publications

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“…Vinogradov et al, presented a study where severe plastic deformation re nes the microstructure and produces a modi cation on the surface texture of Mg, improving the resistance(69)(70)(71)(72)(73) (74). Afandy et al, has reported that some mechanical treatments can nano-structure the surface of materials (75). Thermal stability depends on microstructural parameters, such as the composition of the phases (76).…”

Section: Methodsmentioning

confidence: 99%

Bio-fabrication and experimental validation of an Mg – 25Ca – 5Zn alloy proposed for a porous metallic scaffold.

Becerra

Rodríguez

León

et al. 2021

Preprint

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Background The bio-fabrication of a porous scaffold from a selection procedure of elements taking into account the biological behavior, using Magnesium (Mg) alloyed with Calcium (Ca) and Zinc (Zn), it could work as a treatment for specific pathologies in trauma and oncology, on the one hand, in osteosynthesis, contributing to osseointegration and contributing to infection control through the release of drugs, additionally, another possible attribute of this alloy would be to be used as a complementary treatment for osteosarcoma, this is due to the basification produced by oxidative degradation. (Attack on cancer cells)(1)(2)(3)(4).Methods The evaluation of cell viability of an alloy of Mg − 25 wt% Ca + 5 wt% Zn will strengthen current perspectives on the use of Mg in the clinical evaluation of various treatments in trauma and oncology. Considerations on the preparation of an alloy of Mg − 25 wt% Ca + 5 wt% Zn and its morphological characterization, will help to understand the applicability for the development of new surgical techniques and lead to a deeper investigation in the conception of alternative treatments. However, it is very important to bear in mind the mechanical effect of elements such as Ca and Zn, on the degradation of the alloy matrix, the best alternative to predict the biological - mechanical potential starts with the selection of the essential - nutritional elements (5)(6)(7) and its mechanical evaluation by micro-indentation due to the fragility of the matrix (8)(9).Results Therefore, the morphological evaluation of the specimens of Mg − 25 wt% Ca + 5 wt% Zn will show the crystallinity of the alloy; these results together generate a contribution regarding the design of biomedical alloys for use in treatments for various medical specialties.Conclusions The results indicated that cell viability is not affected, and there are no morphological changes in the cells.

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Section: Methodsmentioning

confidence: 99%

Bio-fabrication and experimental validation of an Mg – 25Ca – 5Zn alloy proposed for a porous metallic scaffold.

Becerra

Rodríguez

León

et al. 2021

Preprint

View full text Add to dashboard Cite

show abstract

“…Vinogradov et al presented a study where severe plastic deformation refined the microstructure and produced a modification on the surface texture of Mg, improving the resistance [57][58][59][60][61][62]. Afandy et al has reported that some mechanical treatments can nano-structure the surface of materials [63]. Thermal stability depends on microstructural parameters, such as the composition of the phases [64].…”

Section: Methodsmentioning

confidence: 99%

Bio-Fabrication and Experimental Validation of an Mg - 25Ca - 5Zn Alloy Proposed for a Porous Metallic Scaffold

Becerra

Torres–Castro

2021

Crystals

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This paper proposes the bio-fabrication of a porous scaffold from a selection procedure of elements taking into account biological behavior, using magnesium (Mg) alloyed with calcium (Ca) and zinc (Zn). The proposed scaffold could work as a treatment for specific pathologies in trauma and oncology, on the one hand, in addition to possible applications in osteosynthesis, through contrib-uting to osseointegration and infection control through the release of drugs. Finally, another pos-sible attribute of this alloy could be its use as a complementary treatment for osteosarcoma; this is due to the basification produced by oxidative degradation (attack on cancer cells). The evaluation of cell viability of an alloy of Mg - 25 wt% Ca - 5 wt% Zn will strengthen current perspectives on the use of Mg in the clinical evaluation of various treatments in trauma and oncology. Considera-tions on the preparation of an alloy of Mg - 25 wt% Ca - 5 wt% Zn and its morphological charac-terization will help researchers understand its applicability for the development of new surgical techniques and lead to a deeper investigation of alternative treatments. However, it is very im-portant to bear in mind the mechanical effect of elements such as Ca and Zn on the degradation of the alloy matrix; the best alternative to predict the biological-mechanical potential starts with the selection of the essential-nutritional elements and their mechanical evaluation by mi-cro-indentation due to the fragility of the matrix. Therefore, the morphological evaluation of the specimens of Mg - 25 wt% Ca - 5 wt% Zn will show the crystallinity of the alloy; these results to-gether contribute to the design of biomedical alloys for use in treatments for various medical spe-cialties. The results indicated that cell viability is not affected, and there are no morphological changes in the cells.

show abstract

Characteristic modifications of magnesium and its alloy for future implant material - Review

Cited by 2 publications

References 35 publications

Bio-fabrication and experimental validation of an Mg – 25Ca – 5Zn alloy proposed for a porous metallic scaffold.

Bio-fabrication and experimental validation of an Mg – 25Ca – 5Zn alloy proposed for a porous metallic scaffold.

Bio-Fabrication and Experimental Validation of an Mg - 25Ca - 5Zn Alloy Proposed for a Porous Metallic Scaffold

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