Characteristic of immune response of hepatitis B immunization on infants with two different schedules

Muhammad, Edy; Carmelia, Rita; Yuliati, Yuliati; Lubis, Iskandar Z.; Manoeroeng, S M

doi:10.14238/pi41.4.2001.197-201

Cited by 4 publications

(3 citation statements)

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“…They concluded that nutritional status had no influence on anti-HBs level. (32). Generally, antibody titer will be reduced rapidly at the first year of vaccination and slowly, thereafter (8).…”

Section: Discussionmentioning

confidence: 99%

Vaccine-Induced Anti-HBs Level in 5-6 Year-Old Malnourished Children

et al. 2013

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Background: Malnutrition is the most common cause of immune deficiency. It results in reduced secretion of T-cells and B-cell-stimulating factors leading to declining of special immunoglobulins. On the other hand, hepatitis B, as a major world health problem, can be prevented effectively by vaccination. Three doses of hepatitis B virus (HBV) vaccine induce protective levels of anti-hepatitis B surface (anti-HBs) in 95% of healthy children. This level decreases gradually over time. Objectives: The goal of this study was to assess anti-HBs in malnourished children, who confronted to some degrees of immune deficiency. Patients and Methods: This is a cross-sectional study conducted during May to August 2010 in therapeutic clinics of Yazd, Iran. Samples were selected simply and consecutively among 5-6 year-old children with a history of three doses of HBV vaccine in infancy. On the basis of World Health Organization's definition on malnutrition, which considers anthropometric measurements, malnourished children entered the study. Totally 83 cases (37 boys and 46 girls) were gathered and classified into three groups of mild, moderate, and severe malnutrition. One milliliter of venous blood was taken and anti-HBs were tested by enzyme linked immunosorbant assay (ELISA). Results: Overall, seroprotection rate and geometric mean titer (GMT) of anti-HBs were 60.2% and 15.47 ± 10.92 mIU/mL, respectively. Seroprotection rate was 71.4%, 55.2%, and 72.7% in mild, moderate, and severe malnourished children, respectively. GMT was 30.78 mIU/mL, 12.15 mIU/mL, and 22.95 mIU/mL in these groups, respectively. None of these two indices were significant in these groups (P = 0.471, P = 0.364). Seroprotection rate and GMT were 54.1% and 13.26 ± 11.59 mIU/mL in boys, and 65.2% and 17.5 ± 10.59 mIU/mL in girls, respectively, showing no significant relationship with gender (P = 0.302, P = 0.602). Lowest seroprotection rate was in stunted cases (47.1%) and highest in wasted children (77.8%). This difference also was not significant (P = 0.43). Conclusions:The seroprotection rate and GMT of anti-HBs observed in this study do not show a high level of immunity. These two indices were not related to severity of malnutrition. We conclude that severity of malnutrition does not affect vaccine-induced antibody level and seroprotection rate; however small sample size in each group of study hinders decisive conclusion. Moreover, GMT and seroprotection rate showed no relationship with type of abnormal anthropometric index, including weight for height, weight for age, and height for age.

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Section: Discussionmentioning

confidence: 99%

Vaccine-Induced Anti-HBs Level in 5-6 Year-Old Malnourished Children

et al. 2013

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“…Variasi jadwal imunisasi cukup efektif untuk merangsang kadar imunitas yang tinggi pada bayi dan anak. 31 Penelitian oleh Muhammad dkk, 32 yang merupakan penelitian cross sectional, membandingkan 2 jadwal imunisasi hepatitis B, didapatkan respons imun yang sama setelah vaksinasi pada jadwal imunisasi 0,2,9 bulan ataupun pada 3,4,9 bulan. Penelitian Damme dkk, 33 yang menilai kadar anti-Hbs setelah 5 tahun imunisasi hepatitis B, membandingkan 2 jadwal imunisasi, yaitu grup A diberikan pada 0, 6 bulan sedangkan grup B pada 0,1, 6 bulan pada kelompok umur 11-15 tahun, didapatkan kadar anti-HBs ≥ 10 mIU/ml pada grup A 79,5%, sedangkan pada grup B 91,4%.…”

Section: Pembahasanunclassified

Faktor-Faktor yang Berhubungan dengan Kadar Anti-Hbs pada Anak Sekolah Dasar Setelah 10-12 Tahun Imunisasi Hepatitis B Di Kota Padang

Aswati

Jurnalis

Sayoeti

et al. 2016

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Latar belakang. Hepatitis B merupakan masalah kesehatan global. Risiko kronis hepatitis B akan jauh lebih besar apabila infeksi terjadi pada awal kehidupan dibandingkan usia dewasa. Imunisasi merupakan cara efektif mengontrol infeksi hepatitis B sampai saat ini. Anak yang diimunisasi memperoleh proteksi selama 5-10 tahun. Kadar anti-HBs protektif adalah ≥10 mIU/ml. Apabila daya proteksi setelah pemberian imunisasi pada masa bayi tidak dapat melindungi sampai dewasa, maka booster seharusnya diberikan pada umur prasekolah atau remaja.Tujuan. Mengetahui faktor-faktor yang berhubungan dengan kadar anti-Hbs pada anak SD setelah 10 -12 tahun imunisasi hepatitis BMetode. Penelitian cross sectional dari bulan Januari sampai Maret 2011 pada 110 anak SD di kota Padang yang berusia 10-12 tahun dan telah mendapatkan 3 kali imunisasi hepatitis B saat bayi. Analisis data menggunakan Chi-square dengan tingkat kemaknaan p=0,05Hasil. Dari 110 sampel didapatkan kadar anti-Hbs <10 mIU/ml dan ≥10 mIU/ml masing-masing 58 (52,7%) dan 52 (47,3%) orang. Umur 12 tahun didapatkan kadar anti-Hbs ≥10 mIU/ml (35%). Semua subyek mempunyai gizi baik. Tidak terdapat hubungan yang bermakna antara kadar anti-Hbs dengan jenis kelamin (p= 0,399) dan dengan jadwal imunisasi (p= 0,364).Kesimpulan. Subyek yang berumur lebih besar mempunyai kadar anti-HBs protektif lebih rendah. Tidak terdapat hubungan yang bermakna antara jenis kelamin, jadwal imunisasi dengan kadar anti_HBs setelah 10-12 tahun imunisasi Hepatitis B.

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“…A cross-sectional study by Mohammed et al compared two immunization HB schedules and found that immune responses were similar in children who used an immunization schedule of 3, 4, and 9 months and one of 0, 2, and 9 months. 35 In addition, Damme et al assessed anti-HBs titers 5 years after HB immunization, comparing two immunization schedules. Group A received HB vaccinations at 0 and 6 months, while group B received them at 0, 1, and 6 months.…”

Section: Discussionmentioning

confidence: 99%