Characteristic protein fractions of cerebrospinal fluid disc electrophoretic analysis

Takeoka, Tsuneyuki; Shinohara, Yukito; Furumi, Koichi; Mori, Kosuke

doi:10.1016/0006-8993(80)90350-9

Cited by 9 publications

(3 citation statements)

References 21 publications

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“…Transthyretin in CSF originates predominantly from the choroid plexus, and when the B-CSFB is leaky, its percentage with respect to the rest of the CSF proteins, diminishes due to contamination with plasma proteins. [14] Taking into account the criteria established by Takeoka et al, [15] …”

Section: Analytical Proceduresmentioning

confidence: 99%

An appraisal of blood-cerebrospinal fluid barrier dysfunction during the course of Guillain Barré syndrome

et al. 2009

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Section: Analytical Proceduresmentioning

confidence: 99%

An appraisal of blood-cerebrospinal fluid barrier dysfunction during the course of Guillain Barré syndrome

et al. 2009

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“…In this 2-D electrophoretic study, a spot consisting of low molecular weight polypeptide chains with an acidic PI derived from haptoglobin was found in the majority of 2-D maps of CSF from Alzheimer and VD patients. In some earlier reports, certain haptoglobin polymers were found to enter the CSF from the blood in various pathological conditions (32,33). Impairment of the BBB has, indeed, been described in both AD (34)(35)(36) and VD (34,(36)(37)(38) on the basis of measurements of CSFiserum ratios for plasma proteins.…”

Section: Resultsmentioning

confidence: 93%

Altered blood-brain-barrier function in Alzheimer's disease?

Mattila

Pirttilä

Blennow

et al. 2009

Acta Neurologica Scandinavica

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Alzheimer's disease (AD) and vascular dementia (VD) are the two most common causes of dementia. As yet, no definitive biological antemortem marker has been established for differential diagnosis of AD or VD. In this study, proteins of cerebrospinal fluid (CSF) from AD, VD and control patients were analyzed by two‐dimensional (2‐D) electrophoresis with immobilized pH gradients in the first dimension. No specific changes for AD or VD could be detected in the 2‐D CSF patterns. However, a spot of haptoglobin alpha‐1 chains (13.5 kDa; approximate pI 4.6) was found to be present in the majority of 2‐D CSF maps from the dementia cases, suggesting a high‐molecular‐weight transudate type of alteration in the blood‐brain barrier with considerable frequency in AD.

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“…Taking into account the criteria established by Takeoka et al. [13], the electrophoretic patterns of the stained gels were visually inspected to determine the presence or not of increased B‐CSF B permeability.…”

Section: Procedures For Csf and Serum Samplingmentioning

confidence: 99%