Characteristics and correlates of sensory function in chronic inflammatory demyelinating polyneuropathy

Rajabally, Yusuf A.; Narasimhan, Manisha

doi:10.1016/j.jns.2010.07.003

Cited by 9 publications

(8 citation statements)

References 15 publications

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“…The findings suggest a close relationship between the FMAmp and large‐fiber sensory function. Similar findings were noted in patients with chronic inflammatory demyelinating polyneuropathy in that significant correlations between sensory sum scores and summated CMAPs in the lower limbs were identified . In addition, FMAmp was just as effective at predicting ankle inversion motor function as it was ankle eversion motor function.…”

Section: Discussionsupporting

confidence: 78%

“…Similar findings were noted in patients with chronic inflammatory demyelinating polyneuropathy in that significant correlations between sensory sum scores and summated CMAPs in the lower limbs were identified. 18 In addition, FMAmp was just as effective at predicting ankle inversion motor function as it was ankle eversion motor function. This was found despite the former motion being produced by the tibial-innervated posterior tibialis muscle along with the fibular-innervated anterior tibialis muscle, whereas the latter is produced almost exclusively by the fibular-innervated fibularis longus.…”

Section: Discussionmentioning

confidence: 98%

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Fibular motor nerve conduction studies and ankle sensorimotor capacities

et al. 2012

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Introduction Nerve conduction studies provide information regarding the status of the peripheral nerve, but relationships with sensorimotor capacities that influence mobility have not been defined. Methods A secondary analysis was conducted of data from 41 older subjects (20 women, age 69.1 ± 8.3 years), 25 with diabetic neuropathy of varying severity, and 16 without diabetes or neuropathy. Measurements included routine fibular motor nerve conduction studies and laboratory-based determination of ankle inversion/eversion proprioceptive thresholds and ankle inversion/eversion motor function. Results Independent of age, fibular amplitude correlated robustly with ankle inversion/eversion proprioceptive thresholds (R2 = .591, p < .001), moderately with ankle inversion and eversion rates of torque generation (R2 = .216; p = .004 and R2 = .200; p = .006, respectively), and more strongly when fibular motor amplitude was normalized for body mass index (R2 = .350; p < .001 and R2 = .275; p = .001). Discussion Fibular motor amplitude was strongly associated with ankle sensorimotor capacities that influence lateral balance and recovery from perturbations during gait. The results suggest that nerve conduction study measures have potential for an expanded clinical role in evaluating mobility function in the population studied.

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Section: Discussionsupporting

confidence: 78%

Section: Discussionmentioning

confidence: 98%

Fibular motor nerve conduction studies and ankle sensorimotor capacities

et al. 2012

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“…Still, electrophysiological data are a prerequisite to diagnose CIDP and diagnosis cannot be based on HRUS data. However, different opinions about the suitability of NCS for patient follow‐up were described previously . Progression of disease can be approached by NCS by showing deterioration of myelination or secondary axonal loss.…”

Section: Discussionmentioning

confidence: 99%

“…However, different opinions about the suitability of NCS for patient follow-up were described previously. [27][28][29] Progression of disease can be approached by NCS by showing deterioration of myelination or secondary axonal loss. In our study, we found significant changes of NCS parameters in progressive CIDP only for a decrease of the CMAP amplitudes of the tibial and median nerve at a few time points.…”

Section: Discussionmentioning

confidence: 99%

Clinical, Sonographic, and Electrophysiologic Longitudinal Features of Chronic Inflammatory Demyelinating Polyneuropathy

Fisse

Pitarokoili

Trampe

et al. 2018

Journal of Neuroimaging

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BACKGROUND AND PURPOSE Several studies have aimed to find potential biomarkers to simplify the diagnosis of chronic inflammatory demyelinating polyneuropathy (CIDP) and to monitor and predict the disease course. However, reliable markers are still lacking. We aimed to investigate whether high‐resolution nerve ultrasound (HRUS) is suitable for monitoring the long‐term clinical course of CIDP. METHODS Twenty patients fulfilling the definite diagnostic criteria of CIDP received clinical examination, evaluation of the INCAT (inflammatory neuropathy cause and treatment) overall disability sum score (ODSS) as well as nerve conduction studies, and HRUS every 6 months over a median follow‐up time of 34 months. Patients were divided into clinically stable/regressive disease course or progressive disease course according to the development of the ODSS. RESULTS The intranerve cross‐sectional‐area (CSA) variability of the nerves of the lower extremity increased with disease progression, whereas it remained unchanged in patients with a stable or remitting disease course. CONCLUSION Nerve ultrasound can be used as a method to objectify the long‐term disease course in CIDP patients. The intranerve CSA variability is suitable for monitoring the clinical course of patients with CIDP.

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“…The sensory sum score ranges from 0 to 28, and considers the anatomical distribution of sensory deficits bilaterally in the lower limbs regarding pinprick and light touch sensation (scored as: normal = 4; up to ankle abnormal = 3; up to distal half lower leg abnormal = 2; up to knee abnormal = 1; above knee abnormal = 0), vibration sense (evaluated with a graduated Rydel-Seiffer 64-Hz tuning fork and scored as: normal = 4; decreased/absent at big toe = 3; decreased/absent at ankle = 2; decreased/absent at knee = 1; decreased/absent at crista iliaca = 0), and propriocepsis of distal interphalangeal joint of the big toe (scored as: normal/immediate perception of movement = 2; reduced/delayed perception of movement = 1; absent perception of movement = 0) (13–15). For the motor sum score, manual muscle strength testing was scored according to the Medical Research Council scale in four distal lower limb muscles (tibialis anterior, gastrocnemius, peroneal, toe extensors), resulting in a score from 0 to 40 for both lower limbs (12,15). Those patients with CIAP who had painful sensory symptoms and signs but no significant weakness (i.e., no weakness or only mild weakness of the toe extensors) were classified as having a “painful predominantly sensory CIAP,” because this phenotype is most similar to diabetic polyneuropathy.…”

Section: Methodsmentioning

confidence: 99%

Chronic Idiopathic Axonal Polyneuropathy Is Associated With the Metabolic Syndrome

et al. 2013

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OBJECTIVEThis study aims to investigate the association between chronic idiopathic axonal polyneuropathy (CIAP) and the metabolic syndrome or its individual components.RESEARCH DESIGN AND METHODSA total of 249 patients with CIAP and 709 controls underwent fasting laboratory studies, and blood pressure and waist circumference were measured. The metabolic syndrome was diagnosed if three or more of the following Adult Treatment Panel III criteria were present: impaired fasting glucose, hypertension, abdominal obesity, reduced HDL cholesterol, and hypertriglyceridemia. Subgroup analysis was performed for patients with a painful predominantly sensory CIAP, because this phenotype is most similar to diabetic polyneuropathy. Statistical analysis was performed with adjustment for age and gender.RESULTSFifty-five percent of all patients fulfilled the metabolic syndrome criteria compared with 34% of controls (odds ratio 2.2 [95% CI 1.7–3.0]). Multivariate analysis shows hypertension (2.9 [1.7–4.9]) and abdominal obesity (3.3 [2.4–4.6]) to be significantly more prevalent in patients than in controls. Of the patients classified as having a painful predominantly sensory CIAP, 62% fulfilled the metabolic syndrome criteria (3.1 [2.0–4.8]). In this subgroup, hypertension and abdominal obesity also were significantly more prevalent compared with controls.CONCLUSIONSAbdominal obesity and hypertension seem to be the most consistent contributing components of the metabolic syndrome in patients with CIAP. Evaluation and appropriate treatment of these risk factors in patients with CIAP would be advocated.

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Characteristics and correlates of sensory function in chronic inflammatory demyelinating polyneuropathy

Cited by 9 publications

References 15 publications

Fibular motor nerve conduction studies and ankle sensorimotor capacities

Fibular motor nerve conduction studies and ankle sensorimotor capacities

Clinical, Sonographic, and Electrophysiologic Longitudinal Features of Chronic Inflammatory Demyelinating Polyneuropathy

Chronic Idiopathic Axonal Polyneuropathy Is Associated With the Metabolic Syndrome

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