Characteristics and cyto-compatibility of Collagen/Ca–P coatings on Ti6Al4V substrate

Wang, Rex C.C.; Hsieh, M. C.; Yang, Sung‐Pei; Chuang, Po Kai; Lin, Jui Che; Yang, Chih Hai; Lee, Tzer Min

doi:10.1016/j.surfcoat.2011.04.029

Cited by 15 publications

(21 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The highest cell viability (shown in Table 2) also observedon the Col I terminated films. This could be attributed to the uniform Col I coating formation on the surface, a previous study found that Col I enhanced HOS proliferation [37]. Therefore the presence of native, fibrils structure of the Col I coating layer contributed significant to the improved cytocompatibility of the PLLA film.…”

Section: The Cytocompatibility Of the Modified Plla Filmsmentioning

confidence: 87%

LBL coating of type I collagen and hyaluronic acid on aminolyzed PLLA to enhance the cell-material interaction

Zhao¹,

Zhou²,

Li³

et al. 2014

Express Polym. Lett.

View full text Add to dashboard Cite

Abstract. The aim of the present work is to assemble extracellular matrix components onto poly (L-lactic acid) (PLLA) films using layer-by-layer (LBL) depositing method to enhance the cell-material interaction. To introduce charges onto the hydrophobic and neutral PLLA surface so that the electronic assembly can be processed, poly (ethylene imine) (PEI) was covalently bonded to modify the PLLA films. Positively charged collagen I (Col I) was then deposited onto the aminolyzed PLLA film surface in a LBL assembly manner using hyaluronic acid (HA) as a negatively charged polyelectrolyte. The PEI modification efficiency was monitored via X-ray photoelectron spectroscopy (XPS) measurements. The results of Surface Plasmon Resonance (SPR) and Water contact angle (WCA) monitoring the LBL assemble process presented that the HA/Col I deposited alternately onto the PLLA surface. The surface topography of the films was observed by Atomic force microscope (AFM). In vitro osteoblast culture found that the presence of Col I layer greatly improved the cytocompatibility of the PLLA films in terms of cell viability, cell proliferation and Alkaline Phosphatase (ALP) expression. Furthermore, osteoblast extensions were found to be directed by contact guidance of the aligned Col I fibrils. Thus, these very flexible systems may allow broad applications for improve the bioactivity of polymeric materials, which might be a potential application for bone tissue engineering.

show abstract

Section: The Cytocompatibility Of the Modified Plla Filmsmentioning

confidence: 87%

LBL coating of type I collagen and hyaluronic acid on aminolyzed PLLA to enhance the cell-material interaction

Zhao¹,

Zhou²,

Li³

et al. 2014

Express Polym. Lett.

View full text Add to dashboard Cite

show abstract

“…The adhesive strength of titanium studs adhered using silk solution was found to be 0.096 AE 0.034 MPa, significantly lower than both the egel and melted gel coatings (p 0.01). These adhesion strengths are within the range of 0.07-4.83 MPa [35][36][37][38] obtained with biomaterials such collagen, chitosan, and hydroxyapatite.…”

Section: Implant Coating Adherence and Mechanical Strengthmentioning

confidence: 60%

Silk electrogel coatings for titanium dental implants

et al. 2014

View full text Add to dashboard Cite

The aim of this study was to develop biocompatible, biodegradable dental implant coatings capable of withstanding the mechanical stresses imparted during implant placement. Two techniques were developed to deposit uniform silk fibroin protein coatings onto dental implants. Two novel coating techniques were implemented to coat titanium shims, studs, and implants. One technique involved electrodeposition of the silk directly onto the titanium substrates. The second technique consisted of melting electrogels and dispensing the melted gels onto the titanium to form the coatings. Both techniques were tested for coating reproducibility using a stylus profilometer and a dial thickness gauge. The mechanical strength of adhered titanium studs was assessed using a universal mechanical testing machine. Uniform, controllable coatings were obtained from both the electrodeposition and melted electrogel coating techniques, tunable from 35 to 1654 µm thick under the conditions studied, and able to withstand delamination during implantation into implant socket mimics. Mechanical testing revealed that the adhesive strength of electrogel coatings, 0.369 ± 0.09 MPa, rivaled other biologically derived coating systems such as collagen, hydroxyapatite, and chitosan (0.07-4.83 MPa). These novel silk-based techniques offer a unique approach to the deposition of safe, simple, mechanically robust, biocompatible, and degradable implant coatings.

show abstract

“…An easier way to coat this layer on Ti 6 Al 4 V was created [8]. The intermediate layer used was Ca-P and collagen was coated over it.…”

Section: Collagen Coatingmentioning

confidence: 99%

“…To vary the biological interactions taking place in Ti 6 Al 4 V substrate, collagen coating is considered to be an effective way. Preparation of uniform collagen coating is difficult by direct collagen coating method [8]. A study on simple and efficient method of coating was studied with a precoating of biomimetic Ca-P intermediate layer.…”

Section: Hydroxyapatite Coatingsmentioning

confidence: 99%

See 1 more Smart Citation

Enhancing the Properties of Ti6Al4V as a Biomedical Material: A Review

Annamalai¹,

Kavitha²,

Ramji³

2014

TOMSJ

View full text Add to dashboard Cite

Abstract:The alloy Ti 6 Al 4 V has evolved as a good biomedical material, by virtue of its bio-compatibility. In order to make implants out of this material, it has to be shaped and processed. Shaping this material by conventional manufacturing methods like machining, welding and brazing presents a huge challenge. This challenge has been met by various approaches like additive manufacturing, surface alloying and heat treatment. Additive manufacturing processes are used for shaping; coatings and surface alloying are used for property improvement; heat treatment is used for improving the machinability. The processing method has an impact on the final properties of the product. This review attempts to trace the development of methods and practices for converting Ti 6 Al 4 V into a useful material for biomedical applications.

show abstract

Characteristics and cyto-compatibility of Collagen/Ca–P coatings on Ti6Al4V substrate

Cited by 15 publications

References 28 publications

LBL coating of type I collagen and hyaluronic acid on aminolyzed PLLA to enhance the cell-material interaction

LBL coating of type I collagen and hyaluronic acid on aminolyzed PLLA to enhance the cell-material interaction

Silk electrogel coatings for titanium dental implants

Enhancing the Properties of Ti6Al4V as a Biomedical Material: A Review

Contact Info

Product

Resources

About