The occurrence of downhole debris flows in caving mines has burst, concealment, and destruction characteristics. This study aimed to investigate accurate prevention and control measures for downhole debris flows. The research background was a downhole debris flow in the Plan copper mine. The disaster chain theory was applied to study prevention and control methods for downhole debris flows. Using a model of source generation, chain breaking, and disaster reduction, we proposed accurate prevention and control measures for downhole debris flow disasters, which prevent and control the downhole debris flows at the source. The results showed that the disaster chain type of downhole debris flow disasters is the compound periodic cycle chain, which has the characteristics of the branch basin chain and the periodic cycle chain. Based on the chain-effect nature of disasters caused by downhole debris flows, active and passive prevention and control methods for downhole debris flow disasters were proposed. The active prevention and control measures for chain breaking and disaster reduction involve isolating the generation conditions from the source, inducing a downhole debris flow disaster. This prevention and control method is difficult to implement during the actual production process. The idea of disaster reduction through passive defensive chain breaking is based on the fact that if the three essential types of conditions for the downhole debris flow formation are not present at the same time, then a disaster accident of a downhole debris flow can be effectively prevented and controlled. Accordingly, the following measures are proposed for preventing and controlling downhole debris flows: (1) reinforcement measures applied to the slope body of the landslide material source in the collapse pit; (2) adopting comprehensive flood control measures such as locking, intercepting, dispersing, draining, and blocking under hydraulic conditions; (3) blocking the formation of the channel by adjusting the ore drawing conditions; (4) addressing the inducing factors by blasting with a small amount of explosive. According to the disaster chain theory, prevention, and control methods for downhole debris flow in caving mines were investigated in this study, which not only broadens the research of the debris flows but also fills the gap in the systematic research on downhole debris flows.