Characteristics and Epidemiological Investigation of Paratuberculosis in Dairy Cattle in Tai’an, China

Cheng, Ziqiang; Liu, Mengda; Wang, Peng; Liu, Peng; Chen, Meng; Zhang, Jiandong; Liu, Sidang; Wang, Fangkun

doi:10.1155/2020/3896754

Cited by 13 publications

(8 citation statements)

References 41 publications

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“…However, different regions had a different prevalence. In northern and northeastern China, the seroprevalence of MAP was 11.79%, with a 20.35% herd-level seroprevalence; in Shandong Province, the herd prevalence was about 60%, and the animal level was around 10% [15,16]; and in Inner Mongolia, the prevalence was 10.79%, based on serum tests [17]. This highlights the widespread nature of the disease within dairy cattle populations and underscores the urgent need for effective control and management strategies in China.…”

Section: Introductionmentioning

confidence: 92%

Individual- and Herd-Level Milk ELISA Test Status and Incidence for Paratuberculosis in Hubei Province, China

Chen,

Hou,

Khalid

et al. 2024

Veterinary Sciences

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Mycobacterium avium subsp. paratuberculosis (MAP) is responsible for the persistent infectious illness known as bovine paratuberculosis, which is one of the most easily overlooked diseases in China amid a lack of epidemiological data. In this study, we evaluated the agreement of milk and blood antibody tests for paratuberculosis and showed an overall agreement of 92.0%, with a 95.0% negative coincidence rate and a 78.6% positive coincidence rate. The milk test was then used to examine the prevalence and incidence of dairy cows in Hubei Province, China. We found that, at the individual level, the highest lacto-prevalence reached up to 22.9%; the farm-level prevalence was as high as 92.3% (12/13) and 84.6% (11/13) in January and April 2018, respectively. The total incidence risk of all farms was 6% per three months. We also found that large-scale farms had a significantly lower prevalence and incidence than small-scale farms. Finally, the correlation between paratuberculosis and milk quality was evaluated, and we confirmed that MAP can significantly alter milk quality and raise somatic cell counts in the milk. This study provides valuable information for assessing the prevalence and incidence risk of paratuberculosis in China. It further provides an essential basis for calling for the prevention and control of paratuberculosis in China.

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Section: Introductionmentioning

confidence: 92%

Individual- and Herd-Level Milk ELISA Test Status and Incidence for Paratuberculosis in Hubei Province, China

Chen,

Hou,

Khalid

et al. 2024

Veterinary Sciences

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“…The study has shown that the overall MAP seroprevalence in the tested Tibetan sheep was 11.29% (12). Recent studies showed that paratuberculosis was widely prevalent in dairy farms in Tai'an, Shandong Province (13). Therefore, more attention should be paid to the epidemic prevention and control of paratuberculosis.…”

Section: Introductionmentioning

confidence: 99%

Identification of Mycobacterium avium subspecies paratuberculosis in sheep farms in Bayannaoer, Inner Mongolia, China

Zhang

et al. 2021

Preprint

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Background Paratuberculosis, is a widespread chronic infection of Mycobacterium avium subsp. paratuberculosis (Map), causes significant economic losses to the sheep industry. The current study investigated this disease, which causes diarrhea in sheep, particularly, in Bayannaoer, Inner Mongolia. Diagnosis was based on clinical symptoms, pathological autopsy, histopathological inspection, and serological and molecular methods. Results Paratuberculosis was confirmed via a polymerase chain reaction using DNA extracted from tissue and fecal samples. Serum samples from 472 individual sheep were obtained to detect antibodies against MAP by ELISA test and MAP antibodies were separately detected in 17.86% (35/196) and 18.48% (51/276) of sheep herds at 6 months and 1 years of age respectively. The results of tissue lesion and pathological section were consistent with paratuberculosis infection. Conclusions This is the first report of Mycobacterium avium subspecies paratuberculosis seroprevalence in Bayannaoer sheep in Inner Mongolia. Our findings show that MAP was prevalent and potentially threaten in this region and more further investigations on long-term epidemiological

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“…The symptoms include diarrhea, progressive weight loss, and decreased milk production. Affected animals usually die after suffering cachexia and dehydration [ 2 , 3 ]. A long subclinical phase with probable intermittent shedding before the high shedding clinical phase is among the significant characteristics of this disease in cows [ 4 ].…”

Section: Introductionmentioning

confidence: 99%

Immunoinformatics analysis of candidate proteins for controlling bovine paratuberculosis

2022

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Background Paratuberculosis is debilitating chronic enteritis usually characterized by diarrhea, decreased milk production, and progressive cachexia. Mycobacterium avium subspecies paratuberculosis (MAP) causes significant economic losses by affecting dairy herds globally. Development of protective vaccines is considered as one of the most effective controlling measures for MAP infections. In the current study, hydrophilic parts of MAP2191 and FAP-P proteins as two vaccine candidates were analyzed using immunoinformatics approaches. Methods After selecting the most hydrophilic parts of MAP2191 and FAP-P, helper and cytotoxic T-cell epitopes of ht-MAP2191 and ht-FAP-P were identified. The immunogenic, toxicity and physicochemical properties were assessed. Secondary structures of these proteins were predicted, and their tertiary structures were modeled, refined, and validated. Linear and conformational epitopes of corresponding B-cells were recognized. Then ht-MAP2191 and ht-FAP-P epitopes were employed for molecular docking simulations. Results The results indicated that ht-MAP2191 and ht-FAP-P were immunogenic, non-allergenic, and non-toxic and possess potent T-cell and B-cell epitopes. Eventually, these protein constructs were docked favorably against TLR4. Conclusion According to the findings, ht-MAP2191 and ht-FAP-P could be effective protein-based vaccine candidates for paratuberculosis. It should be noted that to examine their efficacy, further in vitro and in vivo experiments are underway.

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Characteristics and Epidemiological Investigation of Paratuberculosis in Dairy Cattle in Tai’an, China

Cited by 13 publications

References 41 publications

Individual- and Herd-Level Milk ELISA Test Status and Incidence for Paratuberculosis in Hubei Province, China

Individual- and Herd-Level Milk ELISA Test Status and Incidence for Paratuberculosis in Hubei Province, China

Identification of Mycobacterium avium subspecies paratuberculosis in sheep farms in Bayannaoer, Inner Mongolia, China

Immunoinformatics analysis of candidate proteins for controlling bovine paratuberculosis

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