Characteristics and management of hydrocephalus in adult patients with cerebellar glioblastoma: lessons from a French nationwide series of 118 cases

Picart, Thiébaud; Dumot, Chloé; Meyronet, David; Pallud, Johan; Métellus, Philippe; Zouaoui, Sonia; Ducray, François; Pélissou-Guyotat, I.; Berhouma, Moncef; Bauchet, Luc; Guyotat, Jacques

doi:10.1007/s10143-021-01578-2

Cited by 8 publications

(7 citation statements)

References 46 publications

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“…Posterior fossa tumors are associated with the risk of development of both obstructive and communicating hydrocephalus from as low as 10% up to 50% [25][26][27] . A nationwide French study of adult patients with cerebellar glioblastoma by Picart et al 28 reported that 41.5% of patients presented with hydrocephalus, similar to our cohort (36.7% of patients). Unlike cerebellar glioblastoma, hydrocephalus on admission was a negative predictor of OS in patients with CPA glioblastoma.…”

Section: Discussionsupporting

confidence: 90%

An integrative survival analysis and a systematic review of the cerebellopontine angle glioblastomas

Lasica

Arnautović

Tomita

et al. 2023

Sci Rep

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Glioblastomas presenting topographically at the cerebellopontine angle (CPA) are exceedingly rare. Given the specific anatomical considerations and their rarity, overall survival (OS) and management are not discussed in detail. The authors performed an integrative survival analysis of CPA glioblastomas. A literature search of PubMed, Scopus, and Web of Science databases was performed per PRISMA guidelines. Patient data including demographics, clinical features, neuroimaging, management, follow-up, and OS were extracted. The mean age was 39 ± 26.2 years. The mean OS was 8.9 months. Kaplan–Meier log-rank test and univariate Cox proportional-hazards model identified hydrocephalus (log-rank, p = 0.034; HR 0.34; 95% CI 0.12–0.94; p = 0.038), chemotherapy (log-rank, p < 0.005; HR 5.66; 95% CI 1.53–20.88; p = 0.009), and radiotherapy (log-rank, p < 0.0001; HR 12.01; 95% CI 3.44–41.89; p < 0.001) as factors influencing OS. Hydrocephalus (HR 3.57; 95% CI 1.07–11.1; p = 0.038) and no adjuvant radiotherapy (HR 0.12; 95% CI 0.02–0.59; p < 0.01) remained prognostic on multivariable analysis with fourfold and twofold higher risk for the time-related onset of death, respectively. This should be considered when assessing the risk-to-benefit ratio for patients undergoing surgery for CPA glioblastoma.

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Section: Discussionsupporting

confidence: 90%

An integrative survival analysis and a systematic review of the cerebellopontine angle glioblastomas

Lasica

Arnautović

Tomita

et al. 2023

Sci Rep

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“…Some studies have shown that there are differences in the expression of some inflammatory indexes in different neurosurgical diseases [ 11 , 12 ]. Detecting these inflammatory indicators can help us quickly identify the types of secondary hydrocephalus, so as to guide our clinicians to take reasonable and effective treatment measures to better improve the quality of life and prognosis of patients [ 13 , 14 ].…”

Section: Introductionmentioning

confidence: 99%

[Retracted] Value of CSF‐Cl, CSF‐GS, CSF‐MALB, and CSF‐ADA in Differential Diagnosis of Secondary Hydrocephalus

Huang

Chen

2022

Contrast Media & Molecular Imaging

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Objectives. To investigate the value of cerebrospinal fluid chloride (CSF-Cl), cerebrospinal fluid glucose (CSF-GS), cerebrospinal fluid microalbumin (CSF-MALB), and cerebrospinal fluid adenosine deaminase (CSF-ADA) in the differential diagnosis of secondary hydrocephalus. Methods. 103 patients with secondary hydrocephalus treated in our hospital from January 2018 to April 2022 were selected. According to different types, it is divided into the hemorrhagic hydrocephalus group and tumor hydrocephalus group. By detecting the levels of inflammatory factors such as CSF-Cl, CSF-GS, CSF-MALB, and CSF-ADA in the two groups, we can analyze the value of these inflammatory factors in the differential diagnosis of secondary hydrocephalus. Results. The level of CSF-MALB in the hemorrhagic hydrocephalus group was significantly higher than that in the tumor hydrocephalus group, and the difference between the two groups was statistically significant ( P < 0.05 ). There was no significant difference in the levels of CSF-Cl, CSF-GS, and CSF-ADA between the two groups ( P > 0.05 ). The area under ROC curve (AUC) of CSF-Cl, CSF-GS, CSF-MALB, and CSF-ADA in the differential diagnosis of secondary hydrocephalus was 0.438, 0.553, 0.750, and 0.542, respectively, sensitivity was 15.1%, 45.3%, 79.2%, and 18.9%, respectively, and specificity was 96.0%, 80.0%, 80.0%, and 94.0%, respectively. Conclusions. The inflammatory reaction of hemorrhagic hydrocephalus was significantly greater than that of tumor hydrocephalus. Moreover, CSF-MALB is closely related to the pathogenesis of hemorrhagic hydrocephalus. At the same time, CSF-MALB can be used as a good index for rapid differential diagnosis of secondary hydrocephalus.

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“…The present study analyzes for the first time the clinical significance of cGBM heterogeneity while previous studies based on the present cohort were dedicated to the surgical management of cGBM. 16,17 Herein, it is demonstrated that tumors diagnosed as cGBM represent a heterogenous group that requires further subclassification to optimally manage patients. Based on clinical information (NF1 diagnosis, previous radiotherapy) and targeted molecular analysis, it was possible to classify 70% of the A B tumors into clinically relevant subgroups and identify 2 subgroups (MAPK pathway-activated and TERT promoter-mutant/EGFR-amplified groups) independently associated with outcome.…”

Section: Discussionmentioning

confidence: 99%

“…For this study, adults with cerebellar tumors diagnosed as GBMs based on the WHO 2007 classification between 2003 and 2017 were identified from the FBTDB and the Club de Neuro-Oncologie of the Société Française de Neurochirurgie 16,17…”

Section: Methodsmentioning

confidence: 99%

“…14,15 For this study, adults with cerebellar tumors diagnosed as GBMs based on the WHO 2007 classification between 2003 and 2017 were identified from the FBTDB and the Club de Neuro-Oncologie of the Société Française de Neurochirurgie. 16,17 Inclusion criteria were: (1) age 18 years and above at diagnosis; (2) tumor epicenter located in the cerebellum with a brainstem infiltration ≤ 5 mm; and (3) surgical management between November 1, 2003, and August 1, 2017. Exclusion criteria were: (1) the presence of a supratentorial or medullar tumor larger than the cerebellar tumor; and (2) recurrent tumors.…”

Section: Identification Of Cgbm Patientsmentioning

confidence: 99%

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Molecular Characterization of Adult Tumors Diagnosed as Cerebellar Glioblastomas Identifies Subgroups Associated With Prognosis

Picart

Poncet

Barritault

et al. 2022

American Journal of Surgical Pathology

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Adult tumors diagnosed as cerebellar glioblastoma (cGBM) are rare and their optimal classification remains to be determined. The aim of this study was to identify subgroups of cGBM based on targeted molecular analysis. cGBM diagnosed between 2003 and 2017 were identified from the French Brain Tumor Database and reviewed according to the WHO 2021 classification. The following molecular alterations were studied: IDH1/2, H3F3A, FGFR1, BRAF, TERT promoter mutations, EGFR amplification, MGMT promoter methylation, and alternative lengthening of telomere status. DNA methylation profile was assessed in a subset of cases. Eighty-three cGBM were included and could be classified into 6 mutually exclusive subgroups associated with median age at diagnosis (MA) and prognosis: TERT-mutant and/or EGFR-amplified tumors (n=22, 26.5%, MA=62 y, median overall survival [OS]=4 mo), H3K27M-mutant tumors (n=15, 18.1%, MA=48 y, median OS=8 mo), mitogen-activated protein kinases (MAPK) pathway–activated tumors (FGFR1, BRAF mutation, or occurring in neurofibromatosis type I patients, n=15, 18.1%, MA=48 y, median OS=57 mo), radiation-associated tumors (n=5, 6%, MA=47 y, median OS=5 mo), IDH-mutant tumors (n=1), and unclassified tumors (n=25, 30.1%, MA=63 y, median OS=17 mo). Most MAPK pathway–activated tumors corresponded to high-grade astrocytomas with piloid features based on DNA methylation profiling. In multivariate analysis, MAPK pathway–activating alterations, ATRX loss of expression, and alternative lengthening of telomere positivity were independently associated with a better outcome and TERT/EGFR alterations with a worse outcome. cGBM display an important intertumoral heterogeneity. Targeted molecular analysis enables to classify the majority of tumors diagnosed as cGBM into mutually exclusive and clinically relevant subgroups. The presence of MAPK pathway alterations is associated with a much better prognosis.

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Characteristics and management of hydrocephalus in adult patients with cerebellar glioblastoma: lessons from a French nationwide series of 118 cases

Cited by 8 publications

References 46 publications

An integrative survival analysis and a systematic review of the cerebellopontine angle glioblastomas

An integrative survival analysis and a systematic review of the cerebellopontine angle glioblastomas

[Retracted] Value of CSF‐Cl, CSF‐GS, CSF‐MALB, and CSF‐ADA in Differential Diagnosis of Secondary Hydrocephalus

Molecular Characterization of Adult Tumors Diagnosed as Cerebellar Glioblastomas Identifies Subgroups Associated With Prognosis

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