Molecular Characterization of Adult Tumors Diagnosed as Cerebellar Glioblastomas Identifies Subgroups Associated With Prognosis

Picart, Thiébaud; Poncet, Delphine; Barritault, Marc; Bauchet, Luc; Zouaoui, Sonia; Guyotat, Jacques; Gabut, Mathieu; Fina, Frédéric; Honnorat, Jérôme; Figarella‐Branger, Dominique; Pallud, Johan; Ducray, François; Meyronet, David

doi:10.1097/pas.0000000000001996

Cited by 5 publications

(3 citation statements)

References 47 publications

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“…We processed the FBTDB and, conducted a nationwide population-based study of all histopathologically con rmed meningioma in France. Detailed methodology has previously been published [6][7][8][9][10][11][12]. In summary, FBTDB collects and records data of patients operated on for a PCNST.…”

Section: Methodsmentioning

confidence: 99%

WITHDRAWN: Descriptive epidemiology of 30,223 histopathologically confirmed meningiomas in France: 2006–2015

Depond,

Zouaoui,

Darlix

et al. 2023

Preprint

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Purpose To describe the epidemiology of meningioma operated in France between 2006 and 2015. Methods We processed the French Brain Tumour Database (FBTDB) to conduct a nationwide population-based study of all histopathologically confirmed meningioma in France. Descriptive methods were implemented. Results 30,223 meningiomas cases were operated on 28,424 patients, in 61 centres. Meningioma was 3 times more common in women (74.1% vs. 25.9%). Mean age at surgery was 58.5±13.9 years; 57.9±13.5 years for women vs.59.9 ±14.8 years for men (p<0.001). The incidence of meningioma surgery increased with age. Grade 1, 2, and 3 meningiomas accounted for 83.9%, 13.91% and, 2.19% respectively. The proportion of grade 2 significantly grew over the study period (p<0.001). There was a significant variability of meningioma grading by institutions, especially for grade 2 which spanned from 5.1% up to 22.4% (p <0.001). 89.05% of the patients had solely one meningioma surgery, 8.52% two and, 2.43% three or more. The number of surgeries was associated with the grade of malignancy (p <0.001). Conclusion The FBTBD is an effective source that comforts previous studies and, bring new information from 30,223 meningiomas cases operated on over a 10-year-long period. Three quarters of meningioma were removed in women. The incidence of meningioma surgery increased with age and, peaked at 58.5 years. They were predominantly benign with meningothelial subtype being the most common. However, the rate of grade 2 has significantly grown over the time, on contrary to malignant meningioma proportion, which remained rare and stable over time around 2%.

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Section: Methodsmentioning

confidence: 99%

WITHDRAWN: Descriptive epidemiology of 30,223 histopathologically confirmed meningiomas in France: 2006–2015

Depond,

Zouaoui,

Darlix

et al. 2023

Preprint

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“…Recently two diffuse glioma entities were discovered that have histone 3 (H3) alterations. Both are rare, IDH-wildtype, most often seen in children and young adults, with a prognosis similar to that of glioblastoma, IDHwildtype [18]. MGMT promotor methylation status is a biomarker of both prognostic and therapeutic significance in glioblastoma, IDH wildtype.…”

Section: Immunohistochemistrymentioning

confidence: 99%

Algorithmic approach utilizing histology and immunohistochemistry for the current classification of diffuse glioma

Panambur

2024

Int J Clin Exp Pathol

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Introduction: Diffuse glioma constitutes 28% of primary brain tumors. Until recently morphologic appearance was the only criterion for classifying these tumors. However, WHO 2016 incorporates molecular information in the primary diagnosis of gliomas such as Isocitrate dehydrogenase 1 (IDH1), Alpha thalassemia/mental retardation syndrome X inked (ATRX) as well as 1p/19q codeletion on FISH. In a resource-limited setup where FISH is not available, Alpha internexin (INA) has been suggested as a surrogate IHC marker. Material and methods: Cross-sectional study conducted in the Department of Pathology for two years. Tissue blocks and clinical as well as radiological details were obtained from departmental archives. After assessing the morphologic details, routine IHC markers such as GFAP, Ki67 and P53 along with molecular markers like IDH-1, ATRX, and lNA were applied. Results: Out of 55 cases of diffuse glioma, 23 cases of astrocytoma and 32 cases of oligodendroglioma with an overall mean age of presentation of 41.49 ± 12.47 years. IDH-1 expression among diffuse glioma was 89.1% in our study. Alteration in the ATRX gene expression was observed in 95.7% of astrocytomas. 75% of oligodendrogliomas expressed INA with no significant difference in expression between the two grades. Based on the algorithmic approach using molecular surrogate markers, diffuse gliomas were categorized into six distinct groups. IDH-mutant, ATRX loss of expression astrocytoma and IDH-mutant, INA positive oligodendroglioma are two categories that do not require further molecular testing. This comprises 72.7% of the cases and these do not warrant further workup. Conclusion: Implementation of combined phenotypic-genotypic diagnosis with the use of histomorphology and immunohistochemical surrogates for molecular genetic alterations will yield more homogeneous and narrowly defined diagnostic entities which will provide better prognostication and definitive treatment. It also is cost-effective in a resource-limited setup.

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“…Although TERT promoter mutations are extremely rare in pediatric gliomas, increased TERC and TERT expression are associated with decreased ΟS in high-grade tumors [ 81 ]. Also, in cerebellar glioblastomas TERT promoter mutation and/or EGFR amplification, ATRX loss, and ALT pathway activation have been reported as independent prognostic factors with ATRX loss of expression, and ALT positivity to associated with a better outcome and TERT/EGFR alterations with a worse outcome of the patients [ 82 ].…”

Section: Diagnostic and Predictive Significance Of Telomere Biology I...mentioning

confidence: 99%

The Role of Glia Telomere Dysfunction in the Pathogenesis of Central Nervous System Diseases

Papageorgakopoulou,

Bania,

Lagogianni

et al. 2024

Mol Neurobiol

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Maintaining the telomere length is decisive for the viability and homeostasis process of all the cells of an organism, including human glial cells. Telomere shortening of microglial cells has been widely associated with the onset and progression of neurodegenerative diseases such as Parkinson’s and Alzheimer’s disease. Additionally, traumatic brain injury appears to have a positive correlation with the telomere-shortening process of microglia, and telomere length can be used as a non-invasive biomarker for the clinical management of these patients. Moreover, telomere involvement through telomerase reactivation and homologous recombination also known as the alternative lengthening of telomeres (ALT) has been described in gliomagenesis pathways, and particular focus has been given in the translational significance of these mechanisms in gliomas diagnosis and prognostic classification. Finally, glia telomere shortening is implicated in some psychiatric diseases. Given that telomere dysfunction of glial cells is involved in the central nervous system (CNS) disease pathogenesis, it represents a promising drug target that could lead to the incorporation of new tools in the medicinal arsenal for the management of so far incurable conditions.

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Molecular Characterization of Adult Tumors Diagnosed as Cerebellar Glioblastomas Identifies Subgroups Associated With Prognosis

Cited by 5 publications

References 47 publications

WITHDRAWN: Descriptive epidemiology of 30,223 histopathologically confirmed meningiomas in France: 2006–2015

WITHDRAWN: Descriptive epidemiology of 30,223 histopathologically confirmed meningiomas in France: 2006–2015

Algorithmic approach utilizing histology and immunohistochemistry for the current classification of diffuse glioma

The Role of Glia Telomere Dysfunction in the Pathogenesis of Central Nervous System Diseases

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