Characteristics and management of skin cancers in very elderly patients: A real‐world challenge for clinicians

Lai, Michela; Pampena, Riccardo; Mirra, Marica; Raucci, Margherita; Benati, Elisa; Borsari, Stefania; Lombardi, Mara; Banzi, Maria; Castagnetti, Fabio; Palmieri, Tamara; Piana, Simonetta; Ramundo, D.; Pellacani, Giovanni; Longo, Caterina

doi:10.1111/exd.14627

Experimental Dermatology

2022

DOI: 10.1111/exd.14627

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Characteristics and management of skin cancers in very elderly patients: A real‐world challenge for clinicians

Michela Lai

Riccardo Pampena

Marica Mirra

et al.

Abstract: Melanoma and non-melanoma skin cancers (NMSC), including basal cell carcinoma (BCC) and squamous cell carcinoma (SCC), are the most commonly diagnosed cancers in the western world. Their incidence is rising worldwide while morbidity and mortality rate show stable or decreasing rates. 1 The incidence of skin cancer increases with age, especially regarding NMSC, as a consequence of

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Cited by 4 publications

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“…,51 Wortsman et al postulated that hyperechoic spots could be due to increased acoustic transmission and the consequent hyperechoic posterior reinforcement artifact (e.g. compact micronests of neoplastic cells), other hypothesis include cornified cysts, necrosis or calcification [52][53][54]. Preoperative study of the BCC subtype can help to obtain a complete excision with free margins.…”

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Non‐invasive imaging techniques in presurgical margin assessment of basal cell carcinoma: Current evidence

Janowska

Oranges

Granieri

et al. 2023

Skin Research and Technology

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Background:The diagnosis of basal cell carcinoma (BCC) is based on clinical and dermoscopical features. In uncertain cases, innovative imaging techniques, such as reflectance confocal microscopy (RCM) and optical coherence tomography (OCT), have been used. The main limitation of these techniques is the inability to study deep margins. HFUS (high-frequency ultrasound) and the most recent UHFUS (ultra-highfrequency ultrasound) have been used in various applications in dermatology, but theyare not yet routinely used in the diagnosis of BCC. A key point in clinical practice is to find an imaging technique that can help to reduce post-surgical recurrences with a careful presurgical assessment of the lesional margins. This technique should show high sensitivity, specificity, reproducibility and simplicity of execution. This concept is very important for the optimal management of patients who are often elderly and have many comorbidities. The aim of the paper is to analyse the characteristics of current imaging techniques and the studies in the literature on this topic. Materials and methods:The authors independently searched the MEDLINE, PubMed, Embase, Scopus, ScienceDirect and Cochrane Library databases for studies looking for non-invasive imaging techniques for the presurgical margin assessment of BCC.Results: Preoperative study of the BCC subtype can help to obtain a complete excision with free margins. Different non-invasive imaging techniques have been studied for in vivo evaluation of tumour margins, comparing the histologic evaluation with a radical surgery. The possibility to study the lateral and deep margins would allow a reduction of recurrences and sparing of healthy tissue. Conclusion: HFUS and UHFUS represent the most promising, non-invasive techniquesfor the pre-operative study of BCC facilitating the characterization of vascularization, deep lateral margins and high-risk subtypes, although they are limited by insufficient literature unlike RCM and OCT.

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confidence: 99%

Non‐invasive imaging techniques in presurgical margin assessment of basal cell carcinoma: Current evidence

Janowska

Oranges

Granieri

et al. 2023

Skin Research and Technology

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Green synthesis of CeVO4 nanoparticles using Azadirechta indica leaves extract and their promising applications as an antioxidant and anticancer agent

Ghotekar

Basnet

Lin

et al. 2023

J Sol-Gel Sci Technol

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Neoadjuvant Photodynamic Therapy: An Updated Therapeutic Approach for Non-Melanoma Skin Cancers

Yan,

Wang,

Zhang

et al. 2024

Curr. Treat. Options in Oncol.

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Characteristics and management of skin cancers in very elderly patients: A real‐world challenge for clinicians

Cited by 4 publications

References 51 publications

Non‐invasive imaging techniques in presurgical margin assessment of basal cell carcinoma: Current evidence

Non‐invasive imaging techniques in presurgical margin assessment of basal cell carcinoma: Current evidence

Green synthesis of CeVO4 nanoparticles using Azadirechta indica leaves extract and their promising applications as an antioxidant and anticancer agent

Neoadjuvant Photodynamic Therapy: An Updated Therapeutic Approach for Non-Melanoma Skin Cancers

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