Characteristics and outcome of spontaneous bacterial meningitis in patients with cancer compared to patients without cancer

Pomar, Virginia; Benito, Natividad; López-Contreras, Joaquı́n; Coll, Pere; Gurguí, M.; Domingo, Peré

doi:10.1097/md.0000000000006899

Cited by 13 publications

(11 citation statements)

References 35 publications

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“…It is also interesting to note that some of the data from these studies was consistent with the findings from Europe and North America with respect to serology and the shift in the incidence to older age groups [ 93 , 94 ]. In addition, many of the publications identified in this review, despite having patients in the age group of interest, did not present data on clinical presentation and/or serogroups by age (and indeed when they did present these data, they tended to focus specifically on younger adults) or they presented all meningitis cases together without distinction by pathogenic cause [ 51 , 95 – 100 ].…”

Section: Discussionmentioning

confidence: 99%

Invasive meningococcal disease in older adults in North America and Europe: is this the time for action? A review of the literature

Guedes

Bertrand-Gerentes

Evans³

et al. 2022

BMC Public Health

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Background Neisseria meningitidis is an encapsulated Gram-negative diplococcus that asymptomatically colonises the upper respiratory tract in up to 25% of the population (mainly adolescents and young adults). Invasive meningococcal disease (IMD) caused by Neisseria meningitidis imposes a substantial public health burden,. The case fatality rate (CFR) of IMD remains high. IMD epidemiology varies markedly by region and over time, and there appears to be a shift in the epidemiology towards older adults. The objective of our review was to assess the published data on the epidemiology of IMD in older adults (those aged ≥ 55 years)in North America and Europe. Such information would assist decision-makers at national and international levels in developing future public health programmes for managing IMD. Methods A comprehensive literature review was undertaken on 11 August 2020 across three databases: EMBASE, Medline and BIOSIS. Papers were included if they met the following criteria: full paper written in the English language; included patients aged ≥ 56 years; were published between 1/1/2009 11/9/2020 and included patients with either suspected or confirmed IMD or infection with N. meningitidis in North America or Europe. Case studies/reports/series were eligible for inclusion if they included persons in the age range of interest. Animal studies and letters to editors were excluded. In addition, the websites of international and national organisations and societies were also checked for relevant information. Results There were 5,364 citations identified in total, of which 76 publications were included in this review. We identified that older adults with IMD were mainly affected by serogroups W and Y, which are generally not the predominant strains in circulation in most countries. Older adults had the highest CFRs, probably linked to underlying comorbidities and more atypical presentations hindering appropriate timely management. In addition, there was some evidence of a shift in the incidence of IMD from younger to older adults. Conclusions The use of meningococcal vaccines that include coverage against serogroups W and Y in immunization programs for older adults needs to be evaluated to inform health authorities’ decisions of the relative benefits of vaccination and the utility of expanding national immunization programmes to this age group.

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Section: Discussionmentioning

confidence: 99%

Invasive meningococcal disease in older adults in North America and Europe: is this the time for action? A review of the literature

Guedes

Bertrand-Gerentes

Evans³

et al. 2022

BMC Public Health

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“…Si bien es cierto, la paciente tiene el antecedente de un cáncer de tiroides, al momento del tratamiento no había actividad, pero es necesario conocer que, en comparación con los pacientes con meningitis en la población general, se encuentra una mayor tasa de mortalidad entre los pacientes con cáncer. Además, un estudio encontró que Listeria fue el germen más frecuente entre los pacientes con cáncer (13) .…”

Section: Discussionunclassified

Listeria monocytogenes meningitis in elderly patient

Alva¹,

Biminchumo-Sagastegui²,

Villarreal-Hifume³

et al. 2020

RFMH

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“…Isolate identification and susceptibility tests performance have been described elsewhere [4,21,25,26,[29][30][31].…”

Section: Microbiology Methodsmentioning

confidence: 99%

“…The characteristics of this cohort have been described elsewhere [4,21,25,26], and also how we identified the cases. Data were collected during the hospitalization and the patient was monitored after discharge by one of the authors (PD or VP).…”

Section: Setting and Study Populationmentioning

confidence: 99%

Characteristics and outcome of spontaneous bacterial meningitis in patients with diabetes mellitus

et al. 2020

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Background: Studies on bacterial meningitis in diabetics patients versus non-diabetics are scarce. In patients with diabetes, bacterial meningitis may have a different presentation, etiology and course. We analyzed and compared the characteristics and outcome of spontaneous BM in adult patients with and without diabetes mellitus (DM). Methods: We performed a single-center, prospective observational cohort study, conducted between 1982 and 2017, in a tertiary university hospital in Barcelona (Spain). The primary outcome measure was in-hospital mortality. Results: We evaluated 715 episodes of bacterial meningitis; 106 patients (15%) had diabetes mellitus. Patients with diabetes were older (median 67 [IQR 17] vs 49 [IQR 40] years, p < 0.001) and more often had a Charlson comorbidity score of ≥3 (40% vs 15%, p < 0.001). Neck stiffness (56% vs 75%, p < 0.001), headache (41% vs 78%) p < 0.001), nausea and/or vomiting (32% vs 56% p < 0.001), and rash (12% vs 26%, p = 0.007) were less frequent in diabetics, whereas altered mental status was more common. Streptococcus pneumoniae and Listeria meningitis were the most common etiologic agents (24 and 18%, respectively). Listeria was more frequent (18% vs. 10%, p = 0.033), whereas meningococcal meningitis was less frequent (10% vs 32%, p < 0.001). Overall mortality was higher in patients with diabetes (26% vs 16%, p = 0.025) concerning non-diabetics. Conclusions: Patients with bacterial meningitis and diabetes mellitus are older, have more comorbidities, and higher mortality. S. pneumoniae and L. monocytogenes are the predominant pathogens, Listeria being more common, whereas Neisseria meningitidis is significantly less frequent than in non-diabetics.

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Characteristics and outcome of spontaneous bacterial meningitis in patients with cancer compared to patients without cancer

Abstract: Supplemental Digital Content is available in the text

Cited by 13 publications

References 35 publications

Invasive meningococcal disease in older adults in North America and Europe: is this the time for action? A review of the literature

Invasive meningococcal disease in older adults in North America and Europe: is this the time for action? A review of the literature

Listeria monocytogenes meningitis in elderly patient

Characteristics and outcome of spontaneous bacterial meningitis in patients with diabetes mellitus

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