Characteristics and Prognosis of Childhood Atopic Dermatitis: A Multicenter Study in Turkey

Yüksel, Hasan; Can, Demet; Reisli, İsmail; Uzuner, Nevin; Orhan, Fazıl; Cevit, Ömer; Tahan, Fulya; Canıtez, Yakup; Kuyucu, Semanur; Boz, Adil; Akçay, Ahmet; Yılmaz, Özge

doi:10.1159/000288289

Cited by 10 publications

(9 citation statements)

References 35 publications

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“…Studies performed found a strong relation between eczema and familial atopy (20). In a study including 531 children with AD performed in our country, the rate of familial atopy was reported to be 56.5% (21). In our study, familial atopy was found in approximately half of our subjects (53.5%).…”

Section: Discussionsupporting

confidence: 55%

Atopik dermatit tanı yaşının ek alerjik hastalık gelişimi üzerine etkisi

Aktaş¹,

Canıtez²,

Sapan³

2011

tpa

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Aim:The aim of this study is to determine the effect of age at the time of diagnosis on development of additional allergic diseases and aeroallergen sensitivity in pediatric patients with a diagnosis of AD. Material and Method: The study includes 114 pediatric patients who were diagnosed as atopic dermatitis according to Hanifin and Rajka criteria. After all patients were divided into two groups according to age at the time of diagnosis as less than 24 months and more than 24 months, total serum IgE, inhalant spesific IgE, ECP levels were measrued and skin prick tests were performed. The additional allergic diseases developed during the followup were recorded. Results: 90 patients (%78.9) were under 24 months of age, 24 (%21.1) patients were over 24 months of age, when the patients were gouped according to age at the time of diagnosis. In our study group, mean age at the time of diagnosis was 14.0±21.4 months, the duration for development of an additional allergic disease was 23.8±22.3 months and mean follow-up period was 58.7±41.2 months (min.8 monthsmax.180 months ; median 50.5 months). In the group who were under 24 months of age at the time of diagnosis, a significant difference was determined for development of asthma in the future (p=0.042). Conclusions:To prevent the allergic process in cases in whom atopic dermatitis findings start at an early age, the families should be warned about the allergic diseases associated with the repiratory system and should protect their children from inhalant allergens. (Turk Arch Ped 2011; 46: 299-303)

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Section: Discussionsupporting

confidence: 55%

Atopik dermatit tanı yaşının ek alerjik hastalık gelişimi üzerine etkisi

Aktaş¹,

Canıtez²,

Sapan³

2011

tpa

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“…AD'de pozitif aile öyküsünün majör risk faktörlerinden birisi olarak kabul edilmesi genetik faktörlerin önemini vurgular (7). Ülkemizde yapılan çok merkezli çalışmanın sonucunda da AD'li hastalarda ailede allerji öyküsü %56.5 olarak bildirilmiştir (8). Çalışmamızda da AD'li çocukların %40.7'sinde ailede allerji öyküsü saptanmıştır.…”

Section: Discussionunclassified

Çocuklarda Atopik Dermatit: Ne Kadar Atopik?

Özçeker¹,

Durak²,

Kardelen³

et al. 2017

Asthma Allergy Immunol

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ÖZGiriş: Atopik dermatit (AD) patogenezinde yer alan birçok faktörden birisi de allerjenlere duyarlılıktır. Besin allerjenlerinin önemli rolü olduğu bilinse de inhalan allerjenlerin de etken olduğuna dair kanıtlar artmaktadır. Çalışmada İstanbul' da yaşayan AD'li çocukların klinik özellikleri ve allerjik parametreleri ile birlikte allerjen duyarlılıklarının araştırılması amaçlandı. Gereç ve Yöntem:Çalışmaya Ocak 2010-Aralık 2013 tarihleri arasında İstanbul Üniversitesi İstanbul Tıp Fakültesi Çocuk Alerji ve İmmünoloji Bilim Dalı polikliniğinden AD tanısıyla takip edilen 2-18 yaş arası toplam 826 hasta alındı. Hastaların yaş, cinsiyet, ailede atopi öyküsü, ek allerjik hastalık varlığı, serum total IgE düzeyleri, tam kan sayımında eozinofil yüzdeleri ve allerji deri testi sonuçları kayıt edildi. Bulgular: Çalışmaya alınan ve yaşları 2-18 arası değişen hastaların 340'ı kız (%41.2), 486'sı erkekti (%58.8); yaş ortalaması 6.48 ±3.50 yıl idi. Hastaların %80'i atopik, %20'si non-atopikti. Ig E düzeyi>100kU/l olan hastalarda allerjen duyarlılığı daha fazla idi (p<0.001). Yaş arttıkça allerjen duyarlılığı da artmakta idi (p<0.001). Atopik dermatite eşlik eden allerjik solunum yolu hastalıklarının (astım ve/veya allerjik rinit) allerjen duyarlılığını etkilemediği görüldü (p:0.07). En sık tespit edilen allerjenler sırası ile ev tozu akarları, tatlı ilkbahar otu ve domuz ayrığı otu olarak saptandı.Sonuç: İstanbul' da yaşayan AD'li çocukların %80'inin atopik bünyeli ve ev tozu akarlarının da en önemli allerjen olduğu saptanmıştır. Uygun cilt bakımı ve klasik tedavi yaklaşımlarına rağmen kontrol altına alınamayan hastalarda çevresel faktörler arasında ev tozu allerjisi araştırılmalı ve gerekli önlemler alınmalıdır. ABSTRACTObjective: One of the many factors that involved with the pathogenesis of atopic dermatitis (AD) is sensitivity to allergens. Food allergy is a known etiological factor and evidence connecting sensitivity to inhalant allergens with atopic dermatitis also keeps increasing. Our study aimed to investigate allergen hypersensitivity together with clinical features and allergic parameters of children with atopic dermatitis who live in İstanbul. Materials and Methods:A total of 826 children aged 2-18 years who had been followed-up with an AD diagnosis at the İstanbul University Medical School's Allergy and Immunology Department between January 2010 and December 2013 were included in our study. Age, gender, atopy history in the family, serum levels of total IgE, presence of additional allergic disease, eosinophil percentage in total blood count and the results of skin prick tests were recorded for these patients.Results: Among the patients included in the study, 41.2% (n:340) were female and 58.8% (n=486) were male, and the mean age was 6.48±3.50 years. Atopic children made up 80% and non-atopic children 20% of the patient population. Patients whose Ig E level was >100 were found to be more sensitive to allergens (p<0.001). As age increased, sensitivity to allergens also increased (p<0.001). Accompanying respirator...

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“…in a certain order, beginning with the onset of atopic dermatitis, food allergies, then asthma and allergic rhinitis. [86][87][88] According to the most recent Global Burden of Disease report (GBD, 1990-2019), 34.3 million Indians are estimated to suffer from asthma, which represents around 13% of the global burden. 89 Recent studies have also noted a possible increase in the prevalence of allergic rhinitis and asthma, however eczema remains uncommon in the Indian population compared to other global regions.…”

Section: Food Allergy Ris K Fac Tor S and Their Lik Ely Influen Ce On...mentioning

confidence: 99%

Allergic sensitization to foods in India and other Low–Middle‐income countries

Anand

Ullah

Parthasarathi³

2023

Clin Experimental Allergy

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Food allergy is an important cause of morbidity significantly affecting the quality of life of the sufferer. Food allergy, an important component of the allergy march, may be increasing in prevalence in some regions and constitutes an important public health problem. 1 Awareness of food allergy is increasing in both western as well as developing countries. The burden of challenge-confirmed food allergy in the western world is up to 10%, but is much lower in LMICs.The increasing awareness and prevalence of food allergy has been termed the 'second wave' of allergic diseases after the increased awareness and prevalence of asthma seen in the second half of the 20th century. 2 There are wide variations in the prevalence of food sensitization and food allergy across the globe and it affects

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Characteristics and Prognosis of Childhood Atopic Dermatitis: A Multicenter Study in Turkey

Cited by 10 publications

References 35 publications

Atopik dermatit tanı yaşının ek alerjik hastalık gelişimi üzerine etkisi

Atopik dermatit tanı yaşının ek alerjik hastalık gelişimi üzerine etkisi

Çocuklarda Atopik Dermatit: Ne Kadar Atopik?

Allergic sensitization to foods in India and other Low–Middle‐income countries

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