Characteristics and Prognostic Factors of Bone Metastasis in Patients With Colorectal Cancer

Kawamura, Hidetaka; Yamaguchi, Tatsuro; Yano, Yuzo; Hozumi, Takeshi; Takaki, Yuki; Matsumoto, Hiroshi; Nakano, Daisuke; Takahashi, Keiichi

doi:10.1097/dcr.0000000000001071

Cited by 46 publications

(53 citation statements)

References 24 publications

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“…3). been reported that spine is the leading site of BM from solid tumors [8,9]. And the common sites of BM from CRC are reportedly the spine, followed by the pelvis and long bones, which is highly consistent with our study [10].…”

Section: Treatments For Bmsupporting

confidence: 92%

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A novel risk stratification for predicting prognosis of colorectal cancer patients with bone metastasis

Guan

Quan

et al. 2020

Preprint

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Backgroud: Our understanding in prognosis of bone metastasis (BM) from colorectal cancer (CRC) is limited. We aimed to establish a clinical risk stratification for individually predicting the survival of CRC patients with BM.Methods: A total of 200 CRC patients with BM were included in this study. Survival time from BM diagnosis was estimated using the Kaplan-Meier method. The multivariable COX regression model identified the risk factors on cancer specific survival (CSS). Based on weighted scoring system, the stratification model was constructed to classify patients with BM according to prognostic risk. Discrimination power and calibration ability of risk stratification were measured.Results: The median CSS time was 11 months after BM diagnosis. Lymph node metastasis, CA199 levels, bone involvement, KPS scores, primary tumor resection, bisphosphonates therapy and radiotherapy were identified as predictors of CSS. Four risk groups were stratified according to weighted scoring system, including low risk, medium risk, medium-high risk and high risk group, with 35, 16, 9 and 5 months of median CSS, respectively (P = 0.000). The risk stratification displayed good accuracy in predicting CSS, with acceptable discrimination and calibration.Conclusion: This novel risk stratification predicts CSS in CRC patient with BM using easily accessible clinicopathologic factors, which is recommended for use in individualized clinical decision making in patient with BM.

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Section: Treatments For Bmsupporting

confidence: 92%

“…The CSS did not differ significantly between the two groups (P = 0.571) in univariate analysis. Hidetaka et al also found there is no significant difference in survival between metachronous and synchronous groups after BM diagnosis(P = 0.59) [8].…”

Section: Treatments For Bmmentioning

confidence: 92%

A novel risk stratification for predicting prognosis of colorectal cancer patients with bone metastasis

Guan

Quan

et al. 2020

Preprint

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“…Effective prognostic assessment is crucial for CRC patients diagnosed with synchronous BM. However, there is no complete evaluating system to accurately estimate the prognosis of this group of patients for physicians (6)(7)(8) . The nomogram, a simple statistical predictive tool, is able to predict the survival and prognosis of BM more accurately for CRC patients with visualization results, which can further improve the compliance and therapeutic effect of patients.…”

Section: Discussionmentioning

confidence: 99%

“…International Publisher patient with BM varies widely and there is no available evaluating system to provide prognosis prediction for this group of patients (6)(7)(8) .…”

Section: Ivyspringmentioning

confidence: 99%

A prognostic index model to individually predict clinical outcomes for colorectal cancer with synchronous bone metastasis

Guan¹,

Ma²,

Quan³

et al. 2020

J. Cancer

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Background: The prognosis of synchronous bone metastasis (BM) in colorectal cancer (CRC) is poor and rarely concerned. A clinical tool to evaluate the prognosis and clinical outcomes for BM would be attractive in current clinical practice. Methods: A total of 342 CRC patients with synchronous BM were identified from Surveillance, Epidemiology, and End Results (SEER) database. The cancer specific survival (CSS) was estimated with the Kaplan-Meier method. Prognostic factors were identified from multivariate Cox model, and the final clinical nomogram was developed to predict the CSS. The concordance index (C-index) was used to assess the discriminative ability. Calibration curves were provided to internally validate the performance of the nomogram. Results: The nomogram finally consisted of 6 prognostic factors including age, tumor grade, AJCC N stage, carcinoembryonic antigen (CEA) levels, primary tumor resection and chemotherapy, which translated the effects of prognostic factors into certain scores to predict the 1-, 2-and 3-year CSS for the synchronous BM in CRC patients. The nomogram presented a good accuracy for predicting the CSS with the C-index of 0.742. The calibration of the nomogram predictions was also accurate. Conclusions: This nomogram was accurate enough to predict the CSS of CRC patients with synchronous BM using readily available clinicopathologic factors and could provide individualized clinical decisions for both physicians and patients.

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“…Kawamura et al [ 2 ] aimed to identify the prognostic factors and characteristics associated with survival in 104 CRC patients with bone metastases. The spine was the most common site, mostly in left-sided CRC, followed by pelvis, whereas right-sided CRC was correlated with long bone metastases.…”

Section: Discussionmentioning

confidence: 99%

Colon adenocarcinoma first presenting as shoulder pain. Case report

Gonçalves

Díez-Alonso

Moraza

et al. 2020

International Journal of Surgery Case Reports

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Highlights CRC is one of the top causes of death in high-income countries. Colorectal primary tumours mostly disseminate to liver, lungs and peritoneum. Bone metastases rarely belong to the unique and curable metastases group of patients. Isolated colorectal cancer bone metastases are rare and usually associated with better prognosis. Careful study of the behaviour of rare types of colonic tumours is essential to progress in scientific knowledge.

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Characteristics and Prognostic Factors of Bone Metastasis in Patients With Colorectal Cancer

Cited by 46 publications

References 24 publications

A novel risk stratification for predicting prognosis of colorectal cancer patients with bone metastasis

A novel risk stratification for predicting prognosis of colorectal cancer patients with bone metastasis

A prognostic index model to individually predict clinical outcomes for colorectal cancer with synchronous bone metastasis

Colon adenocarcinoma first presenting as shoulder pain. Case report

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