Characteristics and results of a series of 59 patients with severe pneumonia due to COVID-19 admitted in the ICU

Serrano-Martínez, José Luis; Machado-Casas, Juan Francisco; Redondo-Orts, M.; Manzano-Manzano, F; Castaño-Pérez, José; Pérez-Villares, J.M.

doi:10.1016/j.medine.2020.06.005

Cited by 9 publications

(6 citation statements)

References 8 publications

(7 reference statements)

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“…After screening by abstract and title, 571 articles were selected for full-text assessment. In total, 157 studies evaluating 948,309 patients were included in the meta-analysis (9–159). The characteristics of all the included studies are shown in Table S1 (http://links.lww.com/CCX/B152).…”

Section: Resultsmentioning

confidence: 99%

Intensive Care and Organ Support Related Mortality in Patients With COVID-19: A Systematic Review and Meta-Analysis

Chandel

Leazer

Alcover

et al. 2023

Critical Care Explorations

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OBJECTIVES:To perform a systematic review and meta-analysis to generate estimates of mortality in patients with COVID-19 that required hospitalization, ICU admission, and organ support.DATA SOURCES: A systematic search of PubMed, Embase, and the Cochrane databases was conducted up to December 31, 2021.STUDY SELECTION: Previously peer-reviewed observational studies that reported ICU, mechanical ventilation (MV), renal replacement therapy (RRT) or extracorporeal membrane oxygenation (ECMO)-related mortality among greater than or equal to 100 individual patients.DATA EXTRACTION: Random-effects meta-analysis was used to generate pooled estimates of case fatality rates (CFRs) for in-hospital, ICU, MV, RRT, and ECMO-related mortality. ICU-related mortality was additionally analyzed by the study country of origin. Sensitivity analyses of CFR were assessed based on completeness of follow-up data, by year, and when only studies judged to be of high quality were included.

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Section: Resultsmentioning

confidence: 99%

Intensive Care and Organ Support Related Mortality in Patients With COVID-19: A Systematic Review and Meta-Analysis

Chandel

Leazer

Alcover

et al. 2023

Critical Care Explorations

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“…In total, 6498 abstracts were screened, with 751 full‐text reviews. Fifty‐eight studies with 44,305 patients were included in the review [2, 8‐65]. These included studies provided data on mortality or survival following ICU admission for 43,845 (99.0%) of the patients.…”

Section: Resultsmentioning

confidence: 99%

Factors associated with mortality in patients with COVID‐19 admitted to intensive care: a systematic review and meta‐analysis

et al. 2021

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Summary Identification of high‐risk patients admitted to intensive care with COVID‐19 may inform management strategies. The objective of this meta‐analysis was to determine factors associated with mortality among adults with COVID‐19 admitted to intensive care by searching databases for studies published between 1 January 2020 and 6 December 2020. Observational studies of COVID‐19 adults admitted to critical care were included. Studies of mixed cohorts and intensive care cohorts restricted to a specific patient sub‐group were excluded. Dichotomous variables were reported with pooled OR and 95%CI, and continuous variables with pooled standardised mean difference (SMD) and 95%CI. Fifty‐eight studies (44,305 patients) were included in the review. Increasing age (SMD 0.65, 95%CI 0.53–0.77); smoking (OR 1.40, 95%CI 1.03–1.90); hypertension (OR 1.54, 95%CI 1.29–1.85); diabetes (OR 1.41, 95%CI 1.22–1.63); cardiovascular disease (OR 1.91, 95%CI 1.52–2.38); respiratory disease (OR 1.75, 95%CI 1.33–2.31); renal disease (OR 2.39, 95%CI 1.68–3.40); and malignancy (OR 1.81, 95%CI 1.30–2.52) were associated with mortality. A higher sequential organ failure assessment score (SMD 0.86, 95%CI 0.63–1.10) and acute physiology and chronic health evaluation‐2 score (SMD 0.89, 95%CI 0.65–1.13); a lower PaO2:FIO2 (SMD −0.44, 95%CI −0.62 to −0.26) and the need for mechanical ventilation at admission (OR 2.53, 95%CI 1.90–3.37) were associated with mortality. Higher white cell counts (SMD 0.37, 95%CI 0.22–0.51); neutrophils (SMD 0.42, 95%CI 0.19–0.64); D‐dimers (SMD 0.56, 95%CI 0.43–0.69); ferritin (SMD 0.32, 95%CI 0.19–0.45); lower platelet (SMD −0.22, 95%CI −0.35 to −0.10); and lymphocyte counts (SMD −0.37, 95%CI −0.54 to −0.19) were all associated with mortality. In conclusion, increasing age, pre‐existing comorbidities, severity of illness based on validated scoring systems, and the host response to the disease were associated with mortality; while male sex and increasing BMI were not. These factors have prognostic relevance for patients admitted to intensive care with COVID‐19.

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“… 36 , 37 That small number of death patients in our study was due to the small sample size and to the low mortality rate in our series (14%), which was in the lower limit of the range published by other series from ICU of our country (15–34%). 38 , 39 , 40 Second, we studied mortality at 30 days and mortality at other moment of time have been not studied. Third, the rate of SDRA was higher, not statistically significant, in survivor than in non-survivor patients, possibly due to the small sample size.…”

Section: Discussionmentioning

confidence: 99%

HLA genetic polymorphisms and prognosis of patients with COVID-19

Lorente

Franco

Barrios

et al. 2021

Medicina Intensiva (English Edition)

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Objective Different genetic polymorphisms of human leukocyte antigen (HLA) have been associated with the risk and prognosis of autoimmune and infectious diseases. The objectives of this study were to determine whether there is an association between HLA genetic polymorphisms and the susceptibility to and mortality of coronavirus disease 2019 (COVID-19) patients. Design Observational and prospective study. Setting Eight Intensive Care Units (ICU) from 6 hospitals of Canary Islands (Spain). Patients COVID-19 patients admitted in ICU and healthy subjects. Interventions Determination of HLA genetic polymorphisms. Main variable of interest Mortality at 30 days. Results A total of 3886 healthy controls and 72 COVID-19 patients (10 non-survivors and 62 survivor patients at 30 days) were included. We found a trend to a higher rate of the alleles HLA-A*32 ( p = 0.004) in healthy controls than in COVID-19 patients, and of the alleles HLA-B*39 ( p = 0.02) and HLA-C*16 ( p = 0.02) in COVID-19 patients than in healthy controls; however, all these p-values were not significant after correction for multiple comparisons. Logistic regression analysis showed that the presence of certain alleles was associated with higher mortality, such as the allele HLA-A*11 after controlling for SOFA (OR = 7.693; 95% CI = 1.063–55.650; p = 0.04) or APACHE-II (OR = 11.858; 95% CI = 1.524–92.273; p = 0.02), the allele HLA-C*01 after controlling for SOFA (OR = 11.182; 95% CI = 1.053–118.700; p = 0.04) or APACHE-II (OR = 17.604; 95% CI = 1.629–190.211; p = 0.02), and the allele HLA-DQB1*04 after controlling for SOFA (OR = 9.963; 95% CI = 1.235–80.358; p = 0.03). Conclusions The new finding from our preliminary study of small sample size was that HLA genetic polymorphisms could be associated with COVID-19 mortality; however, studies with a larger sample size before definitive conclusions can be drawn.

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Characteristics and results of a series of 59 patients with severe pneumonia due to COVID-19 admitted in the ICU

Cited by 9 publications

References 8 publications

Intensive Care and Organ Support Related Mortality in Patients With COVID-19: A Systematic Review and Meta-Analysis

Intensive Care and Organ Support Related Mortality in Patients With COVID-19: A Systematic Review and Meta-Analysis

Factors associated with mortality in patients with COVID‐19 admitted to intensive care: a systematic review and meta‐analysis

HLA genetic polymorphisms and prognosis of patients with COVID-19

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