2019
DOI: 10.1186/s12935-019-0911-1
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Characteristics of a novel cell line ZJU-0430 established from human gallbladder carcinoma

Abstract: Background Gallbladder cancer is the most common malignant neoplasm of the biliary tract, responsible for 80–95% of cases. Appropriate models are required for investigating the molecular pathogenesis of gallbladder cancer. Methods In this study, we aimed to establish a gallbladder cancer cell line from primary tumour. Single cell RNA sequencing, Light and electron microscopy, DNA content analysis, cytogenetic analysis, short tandem repeat (STR) DNA fingerprint analysis,… Show more

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Cited by 7 publications
(3 citation statements)
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“…The cell line is also more invasive and the highest migratory ability compared with other GBC cell lines. Zhou et al 21 established a novel ZJU-0430 cell line from a primary GBC. It had various cell morphologies and characteristic epithelial morphologies, with a population doubling time of 19.81 h. ZJU-0430 cells have greater migration, invasiveness, and proliferative ability than GBC-SD cells in vitro.…”
Section: D Gallbladder Cancer Cell Culturementioning
confidence: 99%
“…The cell line is also more invasive and the highest migratory ability compared with other GBC cell lines. Zhou et al 21 established a novel ZJU-0430 cell line from a primary GBC. It had various cell morphologies and characteristic epithelial morphologies, with a population doubling time of 19.81 h. ZJU-0430 cells have greater migration, invasiveness, and proliferative ability than GBC-SD cells in vitro.…”
Section: D Gallbladder Cancer Cell Culturementioning
confidence: 99%
“…The primary GBC develops from gallbladder epithelial cells that undergo transformation into highly invasive tumor cells ( 9 ). Given the availability of primary tumors removed from surgery ( 10 ), a number of cell lines of GBC have been established including GBC-SD, NOZ, ZJU-0430, and OCUG1 cells ( 11 ). However, it is unexpectedly noted that there is still lack of a non-cancerous normal gallbladder epithelial cell line.…”
Section: Introductionmentioning
confidence: 99%
“…Gallbladder cancer (GBC) is the most common malignant tumor of the bile duct system, accounting for 80–95% of all malignant biliary tract tumor cases worldwide ( 1 ). Due to the insidious onset of GBC and the lack of specific symptoms at the early stages, the majority of GBC cases are diagnosed in the middle and late stages of the disease ( 2 ).…”
Section: Introductionmentioning
confidence: 99%