Characteristics of Anaplastic Oligodendrogliomas Short-Term Survivors: A POLA Network Study

Garnier, Louis; Vidal, Chrystelle; Chinot, Olivier; Moyal, E. Cohen-Jonathan; Djelad, Apolline; Bronnimann, Charlotte; Bekaert, Lien; Taillandier, Luc; Frenel, Jean-Sébastien; Langlois, Olivier; Colin, Philippe; Meneï, Philippe; Dhermain, Frédéric; Carpentier, Catherine; Gérazime, Aurélie; Curtit, Elsa; Figarella‐Branger, Dominique; Dehais, Caroline; Ducray, François

doi:10.1093/oncolo/oyac023

Cited by 5 publications

(4 citation statements)

References 42 publications

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“…Studies on 1p19q-codeleted tumors presenting data on pre-operative tumor size have almost consequently shown a correlation between larger tumor size and worse prognosis [ 10 , 14 , 17 , 19 , 34 , 36 , 38 ]. Nevertheless, in a large registry based study by Garton et al no significant correlation was seen between tumor size and survival [ 23 ].…”

Section: Discussionmentioning

confidence: 99%

“…For WHO grade 3, 1p19q-oligodendrogliomas, an interesting publication by Garnier et al specifically addressed short-time survivors (cancer specific survival less than 5 years) [ 36 ]. These patients differed in several ways from the classical survivors and were for example older (median age 57.4), more often presented with symptoms other than only seizures, were more often biopsied, and had a larger preoperative tumor volume (mean 186 cm3).…”

Section: Discussionmentioning

confidence: 99%

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Long-term follow up of patients with WHO grade 2 oligodendroglioma

Carstam,

Latini,

Solheim

et al. 2023

J Neurooncol

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Purpose Since the introduction of the molecular definition of oligodendrogliomas based on isocitrate dehydrogenase (IDH)-status and the 1p19q-codeletion, it has become increasingly evident how this glioma entity differs much from other diffuse lower grade gliomas and stands out with longer survival and often better responsiveness to adjuvant therapy. Therefore, apart from using a molecular oligodendroglioma definition, an extended follow-up time is necessary to understand the nature of this slow growing, yet malignant condition. The aim of this study was to describe the long-term course of the oligodendroglioma disease in a population-based setting and to determine which factors affect outcome in terms of survival. Methods All adults with WHO-grade 2 oligodendrogliomas with known 1p19q-codeletion from five Scandinavian neurosurgical centers and with a follow-up time exceeding 5 years, were analyzed regarding survival and factors potentially affecting survival. Results 126 patients diagnosed between 1998 and 2016 were identified. The median follow-up was 12.0 years, and the median survival was 17.8 years (95% CI 16.0–19.6). Factors associated with shorter survival in multivariable analysis were age (HR 1.05 per year; CI 1.02–1.08, p < 0.001), tumor diameter (HR 1.05 per millimeter; CI 1.02–1.08, p < 0.001) and poor preoperative functional status (KPS < 80) (HR 4.47; CI 1.70–11.78, p = 0.002). In our material, surgical strategy was not associated with survival. Conclusion Individuals with molecularly defined oligodendrogliomas demonstrate long survival, also in a population-based setting. This is important to consider for optimal timing of therapies that may cause long-term side effects. Advanced age, large tumors and poor function before surgery are predictors of shorter survival. Graphical Abstract

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Long-term follow up of patients with WHO grade 2 oligodendroglioma

Carstam,

Latini,

Solheim

et al. 2023

J Neurooncol

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“…However, despite the well-known sensitivity of ODs to radiotherapy and chemotherapy, the survival of patients with OD2s and OD3s is still heterogeneous [ 16 ]. CDKN2A homozygous deletion was recently shown to be associated with a poor prognosis close to that of glioblastomas for IDH-mutant gliomas lacking 1p/19q codeletion, as well as for OD3s [ 3 ].…”

Section: Introductionmentioning

confidence: 99%

A Multigene Signature Associated with Progression-Free Survival after Treatment for IDH Mutant and 1p/19q Codeleted Oligodendrogliomas

Gilhodes

Meola

Peyraga

et al. 2023

Cancers

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Background. IDH mutant and 1p/19q codeleted oligodendrogliomas are the gliomas associated with the best prognosis. However, despite their sensitivity to treatment, patient survival remains heterogeneous. We aimed to identify gene expressions associated with response to treatment from a national cohort of patients with oligodendrogliomas, all treated with radiotherapy +/− chemotherapy. Methods. We extracted total RNA from frozen tumor samples and investigated enriched pathways using KEGG and Reactome databases. We applied a stability selection approach based on subsampling combined with the lasso-pcvl algorithm to identify genes associated with progression-free survival and calculate a risk score. Results. We included 68 patients with oligodendrogliomas treated with radiotherapy +/− chemotherapy. After filtering, 1697 genes were obtained, including 134 associated with progression-free survival: 35 with a better prognosis and 99 with a poorer one. Eight genes (ST3GAL6, QPCT, NQO1, EPHX1, CST3, S100A8, CHI3L1, and OSBPL3) whose risk score remained statistically significant after adjustment for prognostic factors in multivariate analysis were selected in more than 60% of cases were associated with shorter progression-free survival. Conclusions. We found an eight-gene signature associated with a higher risk of rapid relapse after treatment in patients with oligodendrogliomas. This finding could help clinicians identify patients who need more intensive treatment.

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“…Long-term survival is variable and can be hard to predict. 1 , 7 , 9 , 10 Despite surgery and adjuvant treatment, grade 3 oligodendroglioma usually progresses or recurs, and there is little data to guide the next steps of treatment once this occurs. This study examines the clinical course of grade 3 1p/19 co-deleted oligodendroglioma ( IDH1/2 mutant and not otherwise specified [NOS] cases), including whether surgery after progression or recurrence improves prognosis.…”

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confidence: 99%

An expanded role for surgery in grade 3 1p/19q co-deleted oligodendroglioma

Gupta

Nawabi

Emani

et al. 2023

Neuro-Oncology Advances

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Background Grade 3 1p/19q co-deleted oligodendroglioma is an uncommon primary CNS tumor with a high rate of progression and recurrence. This study examines the benefit of surgery after progression and identifies predictors of survival. Methods This is a single-institution retrospective cohort study of consecutive adult patients with anaplastic or grade 3 1p/19q co-deleted oligodendroglioma diagnosed between 2001-2020. Results 80 patients with 1p/19q co-deleted grade 3 oligodendroglioma were included. The median age was 47 years (interquartile range 38–56) and 38.8% were women. All patients underwent surgery, including gross total resection (GTR) for 26.3% of patients, subtotal resection for 70.0% of patients, and biopsy for 3.8% of patients. 43 cases (53.8%) progressed at a median of 5.6 years, and the median OS was 14.1 years. Amongst 43 cases of progression or recurrence, 21 (48.8%) underwent another resection. Patients who underwent a second operation had improved overall survival (p=0.041) and survival after progression/recurrence (p=0.012), but similar time to subsequent progression as patients who did not have repeat surgery (p=0.50). Predictors of mortality at initial diagnosis included a pre-operative KPS under 80 (HR 5.4; 95%CI 1.5-19.2), an STR or biopsy rather than GTR (HR 4.1; 95% CI 1.2-14.2), and a persistent post-operative neurologic deficit (HR 4.0; 95%CI 1.2-14.1). Conclusions Repeat surgery is associated with increased survival, but not time to subsequent progression for progressing or recurrent 1p/19q co-deleted grade 3 oligodendrogliomas recur. Mortality is associated with a pre-operative KPS under 80, lack of GTR, and persistent post-operative neurologic deficits after the initial surgery.

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Characteristics of Anaplastic Oligodendrogliomas Short-Term Survivors: A POLA Network Study

Cited by 5 publications

References 42 publications

Long-term follow up of patients with WHO grade 2 oligodendroglioma

Long-term follow up of patients with WHO grade 2 oligodendroglioma

A Multigene Signature Associated with Progression-Free Survival after Treatment for IDH Mutant and 1p/19q Codeleted Oligodendrogliomas

An expanded role for surgery in grade 3 1p/19q co-deleted oligodendroglioma

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