Characteristics of B cells and immunoglobulin profile in Takayasu's arteritis

Abstract

ObjectiveDisorders of humoral immunity in Takayasu's arteritis (TAK) have not been well explored. This study describes the characteristics of B cells and immunoglobulin (Ig) profile in patients with TAK. Methods Peripheral B cell populations assessed using flow cytometry and serum Ig levels assessed using a biochemical analyserin 98 newly diagnosed patients with TAK were analysed and compared with those of 31 patients with systemic lupus erythematosus (SLE) and 60 healthy controls (HCs). CD19 + B cell and IgG infiltration to the aortic tissue was evaluated by immunohistochemical staining. ResultsThe proportion of peripheral CD3 -CD19 + B cells and levels of serum IgG in TAK were lower than those in SLE, but higher than those in HCs. CD3 -CD19 + B cell counts were higher in TAK than in HCs. Serum IgG and IgG1 levels were higher in active TAK than in non-active TAK. In TAK, positive correlations of serum IgG levels with erythrocyte sedimentation rate (ESR), C-reactive protein (CRP) level, Kerr score, and Indian Takayasu Clinical Activity Score (ITAS2010, ITAS-A) were observed before immunotherapy. After 6 months of immunotherapy, serum Ig levels significantly decreased. Positive correlations between the changes in IgG levels and values of ESR, CRP, Kerr score, and ITAS-A were detected. Immunohistochemical staining confirmed CD19 + B cell and IgG infiltration to the aortic wall in patients with TAK. ConclusionEnhanced B cells might contribute to the pathogenesis of TAK, and serum IgG levels could serve as a simple, useful biomarker to assess disease activity and monitor treatment response in TAK.

Systemic vasculitis: one year in review 2024

“…Patients with active TAK had higher mean serum IgG levels compared to those in clinical remission. Immunosuppressive treatment induced a statistically significant reduction of serum IgG levels, with a positive correlation between serum IgG and both inflammatory markers and disease activity clinimetric indexes, before and after immunosuppressive treatment (31). Preventing the establishment and progression of arterial fibrosis is a relevant unmet need in TAK.…”

“…In a recent retrospective Chinese study, both median peripheral CD3-CD19+ B-cells and mean immunoglobulins G (IgG) were significantly higher when comparing patients with TAK with healthy controls (31). Patients with active TAK had higher mean serum IgG levels compared to those in clinical remission.…”

Cardiologia Teoria e Prática - Edição XIV

“…Posteriormente, a intensa inflamação mononuclear da camada média pode ocorrer, por vezes com padrão granulomatoso, com células gigantes e necrose irregular da mesma. As alterações morfológicas podem ser indistinguíveis das observadas na arterite de células gigantes (KHADKA et al, 2022;LI et al, 2020).…”

“…Na ablação, é realizado um isolamento elétrico dos gatilhos da FA presentes nas veias pulmonares, por meio da radiofrequência ou da crioablação. No método de RF, o isolamento elétrico é rea-lizado através de aplicações pontuais de radiofrequência com base em um mapeamento tridimensional eletro-anatômico, enquanto na crioablação, técnica indicada somente nos ca-sos de FA paroxística e persistente, o isolamento elétrico ocorre através da liberação de crioenergia através de um cateter balão insuflado na veia pulmonar (LI et al, 2020).…”