Characteristics of blood hemostatic markers in a patient with ovarian hyperstimulation syndrome who actually developed thromboembolism

Kodama, Hiroyuki; Fukuda, Jun; Karube, Hiroko; Matsui, Takayoshi; Shimizu, Yasushi; Tanaka, Toshinobu

doi:10.1016/s0015-0282(16)57987-4

Cited by 48 publications

(24 citation statements)

References 4 publications

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“…It is difficult to conclude from these studies whether an overall state of 'hypercoagulability' exists with controlled ovarian stimulation; this finding is hardly surprising with the fact that currently no single 'standard' test is available to measure 'coagulability'. It is, however, clear from many of these studies [105][106][107][108][109] that activation in both the coagulation and fibrinolysis systems occur in patients who undergo ovarian stimulation, and that this activation is greatly exaggerated with the development of OHSS. In one patient who had OHSS and subsequently developed a stroke, the hemostatic changes in that patient were more marked compared with those without complications [106]; whether this difference created a 'hypercoagulable' state is unclear.…”

Section: Recent Findingsmentioning

confidence: 99%

The ‘ART’ of thrombosis: a review of arterial and venous thrombosis in assisted reproductive technology

Chan

2009

Current Opinion in Obstetrics &Amp; Gynecology

112

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Section: Recent Findingsmentioning

confidence: 99%

The ‘ART’ of thrombosis: a review of arterial and venous thrombosis in assisted reproductive technology

Chan

2009

Current Opinion in Obstetrics &Amp; Gynecology

112

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“…Kodama et al stated a statistically significant increase of fibrinogen level and decrease of antithrombin and alpha 2 antiplasmin levels in patients with the severe form of OHSS 7 . They also demonstrated high levels of D-dimers and thrombin -antithrombin complexes, which reflect activation of the coagulation cascade.…”

Section: Discussionmentioning

confidence: 99%

Prevalence of Inherited Thrombophilia in Patients With Severe Ovarian Hyperstimulation Syndrome

Machac¹,

Ľubušký²,

Procházka³

et al. 2006

Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub

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Background and objective:To determine the prevalence of markers of inherited thrombophilia in patients with severe form of ovarian hyperstimulation syndrome (OHSS) Design and methods: Blood samples were analysed for markers of thrombophilia (mutation of factor V -Leiden, mutation of methylentetrahydrofolat reductase (MTHFR) C677T and mutation of prothrombin G20210A). The study group consisted of women who had undergone controlled ovarian hyperstimulation for IVF complicated by severe OHSS (group A, n = 50). Results were compared with two controls groups -women who underwent ovarian hyperstimulation for IVF without developing OHSS (group B, n = 93) and healthy pregnant women with no history of infertility (group C, n = 196).Results: We have found 7 out of 50 patients from group A positive for Leiden mutation (heterozygous) 11 out of 93 from group B (heterozygous), p = 0.71 OR 1.21 (0.39 3.70) and 10 out of 196 from group C (heterozygous), p = 0.03 OR 3.03 (0.97 9.28). Polymorphism of MTHFR 677T gene was detected in 17 out of 50 patients (heterozygous) from group A, in 36 out of 93 patients from group B (35 heterozygous, 1 homozygous) and in 93 out of 196 patients from the group C (86 heterozygous, 7 homozygous) with no statistical significance. Conclusions:We found an increased prevalence of factor V Leiden mutation in Czech infertile women. However carriers of Leiden mutation had no enhanced risk of development severe form of OHSS during stimulation.

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“…Elevated estrogen levels resulting from ovulation induction have a direct impact on the coagulation and anticoagulation system, the imbalance of which may lead to hypercoagulation [43,44,45]. Hyperestrogenemia also causes increased vascular permeability resulting in fluid extravasation into the third space and the development of hypoalbumin, ascites, pleural effusion and hemoconcentration [32].…”

Section: Discussionmentioning

confidence: 99%

The Clinical Characteristics of Acute Cerebrovascular Accidents Resulting from Ovarian Hyperstimulation Syndrome

Yang

Yuan²,

Qin³

et al. 2017

Eur Neurol

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Background and Purpose: Ovarian hyperstimulation syndrome (OHSS) is a serious complication that occurs after the ovarian-induction treatment. Acute cerebrovascular accident is one of the most dangerous manifestations of the syndrome. However, the characteristics of stroke resulting from OHSS have so far not been well summarised in any study. Methods: We reported 2 cases of acute cerebrovascular accidents secondary to OHSS. And then we performed a literature search for reports on this type of stroke, and summarised their characteristics. Results: Thirty-six published cases of this type of stroke were reviewed. Thirty two out of 36 (88.9%) of the women were 35 years old or younger. Stroke in 28 out of 36 (77.8%) of these cases was caused by arterial thrombosis. In 17 out of 28 cases, the involved cerebral vascular branches were mainly middle cerebral artery (MCA) and internal carotid artery (ICA). The acute cerebrovascular accidents happened 7 and 9.25 days after embryo transplantation or 8 and 8.33 days after last human chorionic gonadotropin treatment respectively. The prognosis of patients was relatively good after anticoagulation and some supportive treatments. Conclusion: The MCA and ICA are easily involved in stroke resulting from OHSS. The young age may be a risk factor for developing stroke secondary to OHSS. Once thromboembolism develops, administering appropriate therapy is crucial.

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Characteristics of blood hemostatic markers in a patient with ovarian hyperstimulation syndrome who actually developed thromboembolism

Cited by 48 publications

References 4 publications

The ‘ART’ of thrombosis: a review of arterial and venous thrombosis in assisted reproductive technology

The ‘ART’ of thrombosis: a review of arterial and venous thrombosis in assisted reproductive technology

Prevalence of Inherited Thrombophilia in Patients With Severe Ovarian Hyperstimulation Syndrome

The Clinical Characteristics of Acute Cerebrovascular Accidents Resulting from Ovarian Hyperstimulation Syndrome

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