Characteristics of bone mineral density and densitometry data in patients with osteoarthritis, non-alcoholic steatohepatitis and obesity

Хухліна, О. С.; Liakhovych, O. D.; Kaniovska, L. V.; Shuper, V. O.; Horbatiuk, I.B.; Hryniuk, O. Ye.

doi:10.31688/abmu.2019.54.3.10

Cited by 2 publications

(2 citation statements)

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“…Femoral neck aBMD by DXA . Femoral neck aBMD by DXA was reported in 48 studies [ 52 , 54 , 56 , 58 – 60 , 67 – 72 , 84 , 85 , 88 , 89 , 92 , 93 , 96 , 97 , 101 , 103 , 106 – 108 , 110 – 114 , 118 , 120 , 121 , 124 , 128 , 130 , 142 , 144 , 148 – 153 , 167 , 173 , 177 , 180 , 181 ], including 30,577 participants. Obesity was associated with increased femoral neck aBMD in postmenopausal women (n = 21: MD = 0.06 g/cm 2 , 95% CI: 0.05, 0.08, P<0.00001, I 2 = 90%), premenopausal women (n = 13: MD = 0.05 g/cm 2 , 95% CI: 0.03, 0.07, P<0.00001, I 2 = 92%), men (n = 8: MD = 0.05 g/cm 2 , 95% CI: 0.03, 0.07, P<0.00001, I 2 = 79%), and in studies combining men and women (n = 7: MD = 0.07 g/cm 2 , 95% CI: 0.04, 0.10, P<0.00001, I 2 = 77%) ( S2 Fig ).…”

Section: Resultsmentioning

confidence: 99%

Association between obesity and risk of fracture, bone mineral density and bone quality in adults: A systematic review and meta-analysis

et al. 2021

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Background The association between obesity and fracture risk may be skeletal site- and sex-specific but results among studies are inconsistent. Whilst several studies reported higher bone mineral density (BMD) in patients with obesity, altered bone quality could be a major determinant of bone fragility in this population. Objectives This systematic review and meta-analysis aimed to compare, in men, premenopausal women and postmenopausal women with obesity vs. individuals without obesity: 1) the incidence of fractures overall and by site; 2) BMD; and 3) bone quality parameters (circulating bone turnover markers and bone microarchitecture and strength by advanced imaging techniques). Data sources PubMed (MEDLINE), EMBASE, Cochrane Library and Web of Science were searched from inception of databases until the 13th of January 2021. Data synthesis Each outcome was stratified by sex and menopausal status in women. The meta-analysis was performed using a random-effect model with inverse-variance method. The risks of hip and wrist fracture were reduced by 25% (n = 8: RR = 0.75, 95% CI: 0.62, 0.91, P = 0.003, I2 = 95%) and 15% (n = 2 studies: RR = 0.85, 95% CI: 0.81, 0.88), respectively, while ankle fracture risk was increased by 60% (n = 2 studies: RR = 1.60, 95% CI: 1.52, 1.68) in postmenopausal women with obesity compared with those without obesity. In men with obesity, hip fracture risk was decreased by 41% (n = 5 studies: RR = 0.59, 95% CI: 0.44, 0.79). Obesity was associated with increased BMD, better bone microarchitecture and strength, and generally lower or unchanged circulating bone resorption, formation and osteocyte markers. However, heterogeneity among studies was high for most outcomes, and overall quality of evidence was very low to low for all outcomes. Conclusions This meta-analysis highlights areas for future research including the need for site-specific fracture studies, especially in men and premenopausal women, and studies comparing bone microarchitecture between individuals with and without obesity. Systematic review registration number CRD42020159189

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Section: Resultsmentioning

confidence: 99%

Association between obesity and risk of fracture, bone mineral density and bone quality in adults: A systematic review and meta-analysis

et al. 2021

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“…Studies that have looked at the effects on insulin resistance following vitamin D administration in obese people are contradictor y. Vitamin D deficiency is associated with hyperglycemia, hyperinsulinemia and insulin resistance [41,42]. Von Hurst et al, following vitamin D treatment in women with insulin resistance and overweight, showed a decrease in HOMA-IR, but with no effect on glucose level, lipid profile and inflammatory markers [40].…”

Section: Vitamin D Supplementationmentioning

confidence: 99%

The Complex Context of the Involvement of Vitamin D Deficiency in Obesity

Stănescu¹,

Grăjdeanu²,

Totan³

et al. 2019

Rev. Chim.

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The prevalence of obesity is increasing and morbidity and mortality increase with it. Vitamin D plays an important role in obesity. Determining the exact relationship between obesity and vitamin D may represent a new perspective in the approach and treatment of obesity. Clarifying whether supplementation with vitamin D in overweight people can prevent obesity and whether supplementation in obese people can help weight loss are essential.

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Characteristics of bone mineral density and densitometry data in patients with osteoarthritis, non-alcoholic steatohepatitis and obesity

Cited by 2 publications

References 10 publications

Association between obesity and risk of fracture, bone mineral density and bone quality in adults: A systematic review and meta-analysis

Association between obesity and risk of fracture, bone mineral density and bone quality in adults: A systematic review and meta-analysis

The Complex Context of the Involvement of Vitamin D Deficiency in Obesity

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