Characteristics of cellular composition of periodontal pockets

Hasiuk, P. А.; Hasiuk, N. V.; Kindiy, D. D.; Ivanchyshyn, V. V.; Kalashnikov, D. V.; Zubchenko, Sergiy

doi:10.1556/1646.8.2016.4.5

Cited by 22 publications

(17 citation statements)

References 13 publications

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“…Improved cytomorphometric indicators were observed among patients with periodontal diseases, depending on the material of prostheses. The results revealed improvement among the patients in the C/C-Zr group compared with the C group, which was also confirmed by several studies [ 20 , 22 ].…”

Section: Discussionsupporting

confidence: 84%

“…Several studies have been conducted to determine the cytological composition of gingival crevicular fluid (GCF) in inflammatory diseases of periodontal tissues for diagnostic purposes [ 18 , 19 , 20 , 21 ]. However, there remain no comparative data on the change in GCF parameters during prosthodontic treatment using fixed prosthesis fabricated from various materials [ 22 ].…”

Section: Introductionmentioning

confidence: 99%

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Cytomorphometric Analysis of Inflammation Dynamics in the Periodontium Following the Use of Fixed Dental Prostheses

et al. 2020

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Cytomorphometry is used in the sampling of biological materials and diagnostic procedures. The use of cytological studies in periodontal diseases is not well described in the literature. Our study aimed to quantitatively assess the inflammation dynamics using cytomorphometric analysis of the periodontium before and after the use of fixed dental prostheses. Following ethics approval, a total of 105 subjects were divided in 3 groups as gingivitis (n = 23), periodontitis (n = 58), and healthy periodontium (control) (n = 24). The fixed dental prostheses (crowns and fixed partial dentures) were fabricated from cobalt-chrome metal-ceramic prostheses using the conventional method (C/M-CoCr), cobalt-chrome metal-ceramic prostheses by the computer-aided design and computer-aided manufacturing (CAD/CAM) technique (C/C-CoCr), and zirconia-based ceramic prostheses by the CAD/CAM technique (C/C-Zr) among subjects with gingivitis and periodontitis. The gingival crevicular fluid (GCF) was obtained from subjects before and after the use of the prostheses. The total count of epithelial cells and the connective tissue cells or polymorphonuclear neutrophils (PMNs) in GCF were studied using cytomorphometric analysis. The Statistical Package Tor the Social Sciences (SPSS), Version 20 (IBM Company, Chicago, IL, USA) was used to analyze the results and the significance level was set at p = 0.05. The data for before and after the use of the prostheses were compared using independent t-Tests. Similarly, the results after the use of prostheses in gingivitis, periodontitis, and control in each type of prostheses were compared using One-way ANOVA with post hoc using Scheffe. The total epithelial cells and the PMNs were determined along with the epithelium/leukocyte index. Regardless of the prostheses type used, no significant change in the parameters was identified among patients with a healthy periodontium, before and after prosthetic treatment. In all study groups, a statistically increase (p value < 0.05) was observed in the oral epithelial cell counts and a statistically decrease (p < 0.05) in the PMNs count following the use of the fixed prostheses. Data on cytomorphometric analysis could enable the selection of the most appropriate prostheses for use in patients with periodontal pathologies. When choosing prostheses, changes in the composition of GCF could be considered as a useful criterion for their use.

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Section: Discussionsupporting

confidence: 84%

Section: Introductionmentioning

confidence: 99%

Cytomorphometric Analysis of Inflammation Dynamics in the Periodontium Following the Use of Fixed Dental Prostheses

et al. 2020

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“…These provisions provide further development in the course and agree with the basic developments on the peculiarities of the cytological organization of gums in normal state and in inflammation [18][19]. Some differences are due to age-standardized aspect [20].…”

Section: Resultssupporting

confidence: 73%

Cytological Indices in Children With Gingivitis

Melnyk

Horzov

2018

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Development of gingivitis in children with fixed orthodontic appliances (FOA) is an urgent problem of today's periodontology, requiring elaboration of new methods that would give an opportunity not only to diagnose but also to predict the course of periodontitis in a given population. The investigation was conducted in patients with catarrhal and hypertrophic gingivitis during the treatment by FOA. It was established that cellular composition of gum mucosa undergoes cytosospecific alterations, which is manifested by qualitative changes of gingival epitheliocytes. In this case the indices of pathological shift point to the clinical and morphological form of the diagnosed inflammatory process in the gums. Conclusion. The maximal intensity of the inflammatory process in the gums takes 3 months of using FOA while the cytological criteria in this observation period are the functional state of segmental leukocytes and the alterative changes of intermediate cells in the form of foamy cytoplasm in children with catarrhal gingivitis. In children with hypertrophic gingivitis cytological adjustment indices are destructive changes in the epithelial cells, which manifests itself as the appearance of the naked core elements and signs of necrobiosis against the background of a large number of segmental leukocytes.

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“…The cellularity and degree of cellular changes are characterized by the pathological condition of periodontitis in the patient contingent. In a similar study by Hasiuk et al 23 observed that 15% of immature epithelial cells in the periodontal pockets of patients with generalized periodontics. Lesser number of superficial cells indicates the disturbed maturation of epithelial layers in the gingival mucosa because of inflammation and irritation from pathogens and other factors.…”

Section: Discussionmentioning

confidence: 78%