Characteristics of certain drugs with antioxidant activity and their use in tuberculosis treatment

Shovkun, Ludmila; Kudlay, Dmitry; Nikolenko, N. Yu.; Кампос, Е. Д.

doi:10.21292/2075-1230-2020-98-4-58-64

Cited by 5 publications

(2 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Результаты клинических исследований свидетельствуют о ключевой роли свободнорадикальных процессов в патогенезе заболеваний легких -туберкулёз, бронхиальная астма, рак легкого [13,14,15]. Отмечается важность коррекции системы окислительного гомеостаза при патологии органов дыхания с применением экзогенных средств нефармакологической регуляции с антиоксидантной активностью [16]. Йод-гликозидный комплекс расширяет спектр биологических эффектов кумысного напитка путём активации редокс-чувствительной системы Кеар1/Nrf2/ARE, индуцирующей экспрессию генов, контролирующих синтез эндогенных антиоксидантов.…”

Section: заключениеunclassified

Technology of production of kumis drink enriched with iodine-glycoside complex

Chebotarev

Максютов

2021

Vestn. Voronež. gos. univ. inž. tehnol.

View full text Add to dashboard Cite

The article presents the results of experimental research on the development of a formulation and technology for the industrial production of kumis drink enriched with an iodine-glycoside complex, which is a source of molecular iodine with antioxidant activity. Study of the iodine level in patients with tuberculosis showed the following results: iodine deficiency was diagnosed in 86,7% of the total number of examined patients - the median ioduria in this group of patients ranged from 20 ?g/l to 99 ?g/l. The article describes a technology of production of kumis drink enriched with iodine-glycoside complex, including following operations: acceptance and preparation of raw materials; normalization and preparation of the mixture; pasteurization, homogenization, cooling and insertion of "iodine-glycoside"; preparation of the fermentation culture; fermentation and souring, bottling, maturation of the drink; packaging, labeling and cooling. It also includes the results of evaluating the organoleptic indicators of kumis drink - consistency, taste, color, smell and appearance, as well as the physical and chemical parameters: weight fraction of fat, protein, dry fat-free substances; the volume of settled whey, antioxidant balance in respiratory pathology by activating the KEAP1 /Nrf2 /ARE redox-sensitive system inducing the gene expression that control the endogenous antioxidants synthesis. Binary complex (kumis drink + molecular iodine) is considered here as a non-pharmacological pathogenetic agent. The technological process of the production of a functional product with anti-tuberculosis activity ensured the preservation of the physical and chemical parameters of the kumis drink, reducing the titratable acidity to 44,8% in the iodine-enriched drink against 57,6% in the control sample. The author elaborates on mechanisms of the participation of the “iodine-glycoside complex” and low-molecular organic substances, in particular, the amino acids of the kumis drink, in the regulation of pro-, with pleiotropic properties for the treatment and prevention of tuberculosis.

show abstract

Section: заключениеunclassified

Technology of production of kumis drink enriched with iodine-glycoside complex

Chebotarev

Максютов

2021

Vestn. Voronež. gos. univ. inž. tehnol.

View full text Add to dashboard Cite

show abstract

“…Free radical oxidation, one of the most important bactericidal factors of phagocytes, is of particular importance in tuberculosis [2]. The stimulation of the process, as a protective reaction of the body, is aimed at destroying the pathogen.…”

mentioning

confidence: 99%

Antioxidant and Prooxidant Effects of Curcumin, Piperine and Semi-synthetic Amides with Antimycobacterial Activity on the Lipid Oxidation Process

Slavchev,

Dobrikov,

Momchilova

et al. 2024

C. R. Acad. Bulg. Sci.

View full text Add to dashboard Cite

Free radical oxidation is considered an important factor in the treatment of tuberculosis. Drugs or treatments with antioxidants are reflected in the literature but the choice of those used for tuberculosis is quite limited. Selected natural and synthetic compounds (hybrid molecules consisting of fenchane scaffold and cinnamoyl like residues attached through amide bond), possessing antimycobacterial activity were studied for their capacity to accelerate or decelerate lipid oxidation process. Three of the compounds under study showed prooxidant activity. To the best of our knowledge, this is the first report about the prooxidant activity of piperine under spontaneous autoxidation conditions. The presence of fenchane scaffold together with the 1,3-benzodioxole fragment, positively affects the activity but we can only speculate about the role of the amide part. Effect of equimolar binary mixtures with curcumin has also been studied. These new results may contribute to the search for efficient bio-antioxidant mixtures in the prevention and elimination of adverse reactions of antibacterial drugs.

show abstract

The Severity of Vascular Inflammation and Its Relationship With Clinical and Functional Features in Patients With Chronic Obstructive Pulmonary Disease Without Concomitant Cardiovascular Pathology

Tayutina,

Klimenko,

Kudlay

et al. 2024

Vrach

View full text Add to dashboard Cite

The Russian Federation is one of the countries with a high prevalence of chronic obstructive pulmonary disease (COPD). In the last decade, the list of families of chemical regulators of vascular inflammation in COPD has been supplemented with information about growth factors, whose participation in the processes of regulation of vascular function seems significant. The study of the role of angiogenesis factors in patients with isolated COPD disease is insufficient at this stage and needs to be clarified. Objective. To study was to identify diagnostic and prognostic criteria for the severity of vascular inflammation and to assess its relationship with clinical and functional features in patients with COPD without concomitant cardiovascular pathology in comparison with the clinical phenotype of the disease. Material and methods. 96 patients with COPD were examined, the median age was 61 years. In addition to standard clinical, functional and laboratory research methods, the severity of vascular inflammation was assessed in all examined patients with the determination of quantitative indicators of human platelet growth AA factor and tumor necrosis factor-α (TNFα) by quantitative solid-phase enzyme immunoassay Results. In all patients with isolated COPD, regardless of the risk of developing the underlying disease, an increase in the level of platelet growth AA factor and TNFα was noted. The level of platelet growth AA factor and TNFα in patients with COPD, regardless of the risk of exacerbation, was correlated with the functional state of the lungs, clinical phenotype and severity of clinical manifestations of the disease. The value of platelet growth AA factor above 317 ng/ml in patients with COPD may be an early marker of endothelial dysfunction and a predictor of the development of hemostatic disorders and concomitant cardiovascular pathology.

show abstract

Characteristics of certain drugs with antioxidant activity and their use in tuberculosis treatment

Cited by 5 publications

References 26 publications

Technology of production of kumis drink enriched with iodine-glycoside complex

Technology of production of kumis drink enriched with iodine-glycoside complex

Antioxidant and Prooxidant Effects of Curcumin, Piperine and Semi-synthetic Amides with Antimycobacterial Activity on the Lipid Oxidation Process

The Severity of Vascular Inflammation and Its Relationship With Clinical and Functional Features in Patients With Chronic Obstructive Pulmonary Disease Without Concomitant Cardiovascular Pathology

Contact Info

Product

Resources

About