Characteristics of chitosan-modified glass ionomer cement and their effects on the adhesion and proliferation of human gingival fibroblasts: an in vitro study

Zhou, Jia; Xu, Quanchen; Fan, Chun; Ren, Hao; Xu, Shuo; Hu, Fang; Wang, Lei; Yang, Kai; Ji, Qiuxia

doi:10.1007/s10856-019-6240-z

Cited by 15 publications

(9 citation statements)

References 60 publications

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“…Among the other GIC groups, a significant reduction in cell density and cell spreading was evident in Ionolux. These findings agree with other studies reporting the cytotoxic effects of GICs [35,36].…”

Section: Discussionsupporting

confidence: 93%

In Vitro Evaluation of the Biological Effects of ACTIVA Kids BioACTIVE Restorative, Ionolux, and Riva Light Cure on Human Dental Pulp Stem Cells

et al. 2019

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This study aimed to analyze the biological effects of three new bioactive materials on cell survival, migration, morphology, and attachment in vitro. ACTIVA Kids BioACTIVE Restorative (Pulpdent, Watertown, MA, USA) (Activa), Ionolux (Voco, Cuxhaven, Germany), and Riva Light Cure UV (SDI, Bayswater, Australia) (Riva) were handled and conditioned with a serum-free culture medium. Stem cells from human dental pulp (hDPSCs) were exposed to material extracts, and metabolic activity, cell migration, and cell morphology were evaluated. Cell adhesion to the different materials was analyzed by scanning electron microscopy (SEM). The chemical composition of the materials was evaluated by energy-dispersive X-ray (EDX). One-way analysis of variance followed by a Tukey test was performed (p < 0.05). Ionolux promoted a drastic reduction in metabolic activity and wound closure compared to the control (p < 0.05), whereas Activa induced adequate metabolic activity and cell migration. Moreover, SEM and immunofluorescence analysis showed abundant cells exposed to Activa. The materials showed different surface morphologies, and EDX spectra exhibited different peaks of C, O, Si, S, Ca, and F ions in glass ionomer cements. The results showed that Activa induced cell migration, cell attachment, and cell viability to a greater extent than Riva and Ionolux.

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Section: Discussionsupporting

confidence: 93%

In Vitro Evaluation of the Biological Effects of ACTIVA Kids BioACTIVE Restorative, Ionolux, and Riva Light Cure on Human Dental Pulp Stem Cells

et al. 2019

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“…Moreover, a synergistic effect was found in both antibacterial and mechanical properties when combining chitosan and titanium-dioxide nano-powder [120]. Zhou et al also analyzed whether gingival tissue could adhere to a root surface previously restored with a chitosan-modified GIC and, in agreement with the previous works, they reported the characteristic bimodal behavior of the mechanical properties when increasing the content of chitosan, and demonstrated that 2 wt% was the most cytocompatible dose of chitosan for the growth of human gingival fibroblast, due to the faster flow of fluoride ions to the medium, which consequently combined with H + , increasing the medium pH towards neutrality [121].…”

Section: Glass Ionomer Cementssupporting

confidence: 89%

“…Chitosan [116][117][118][119]121] Chitosan (with TiO 2 nano-powder) [120] Calcium Phosphate Cements 1. Bone fillers for fixating orthopedics and dental implants.…”

Section: Pmma-based Cementsmentioning

confidence: 99%

Antibacterial Bio-Based Polymers for Cranio-Maxillofacial Regeneration Applications

et al. 2020

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Cranio-maxillofacial structure is a region of particular interest in the field of regenerative medicine due to both its anatomical complexity and the numerous abnormalities affecting this area. However, this anatomical complexity is what makes possible the coexistence of different microbial ecosystems in the oral cavity and the maxillofacial region, contributing to the increased risk of bacterial infections. In this regard, different materials have been used for their application in this field. These materials can be obtained from natural and renewable feedstocks, or by synthetic routes with desired mechanical properties, biocompatibility and antimicrobial activity. Hence, in this review, we have focused on bio-based polymers which, by their own nature, by chemical modifications of their structure, or by their combination with other elements, provide a useful antibacterial activity as well as the suitable conditions for cranio-maxillofacial tissue regeneration. This approach has not been reviewed previously, and we have specifically arranged the content of this article according to the resulting material and its corresponding application; we review guided bone regeneration membranes, bone cements and devices and scaffolds for both soft and hard maxillofacial tissue regeneration, including hybrid scaffolds, dental implants, hydrogels and composites.

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“…Moreover, a synergistic effect was found in both antibacterial and mechanical properties when combining chitosan and titanium-dioxide nano-powder [105]. Zhou et al also analyzed whether gingival tissue could adhere to a root surface previously restored with a chitosan-modified GIC and, in agreement to the previous works, they reported the characteristic bimodal behavior of the mechanical properties when increasing the content of chitosan, and demonstrated that 2 wt% was the most cytocompatible dose of chitosan for the growth of human gingival fibroblast, due to the faster flow of fluoride ions to the medium, which consequently combined with H + , increasing the medium pH towards neutrality [106].…”

Section: Glass Ionomer Cementssupporting

confidence: 88%

Antibacterial Bio-Based Polymers for Cranio-Maxillofacial Regeneration Applications

Martín-del-Campo¹,

Fernadez-Villa²,

Cabrera-Rueda³

et al. 2020

Preprint

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Cranio-maxillofacial structure is a region of particular interest in the field of regenerative medicine due to both its anatomical complexity and the numerous abnormalities affecting this area. However, this anatomical complexity is what makes possible the coexistence of different microbial ecosystems in the oral cavity and the maxillofacial region, contributing to the increased risk of bacterial infections. In this regard, different materials have been used for their application in this field. These materials can be obtained from natural and renewable feedstocks or by synthetic routes with desired mechanical properties, biocompatibility and antimicrobial activity. Hence, in this review, we have focused on bio-based polymers, which by their own nature, by chemical modifications of their structure, or by their combination with other elements, provide a useful antibacterial activity as well as the suitable conditions for cranio-maxillofacial tissue regeneration. This approach has not been reviewed previously, and we have specifically arranged the content of this article according to the resulting material and its corresponding application, reviewing guided bone regeneration membranes; bone cements; and devices and scaffolds for both soft and hard maxillofacial tissue regeneration, including hybrid scaffolds, dental implants, hydrogels and composites.

show abstract

Characteristics of chitosan-modified glass ionomer cement and their effects on the adhesion and proliferation of human gingival fibroblasts: an in vitro study

Cited by 15 publications

References 60 publications

In Vitro Evaluation of the Biological Effects of ACTIVA Kids BioACTIVE Restorative, Ionolux, and Riva Light Cure on Human Dental Pulp Stem Cells

In Vitro Evaluation of the Biological Effects of ACTIVA Kids BioACTIVE Restorative, Ionolux, and Riva Light Cure on Human Dental Pulp Stem Cells

Antibacterial Bio-Based Polymers for Cranio-Maxillofacial Regeneration Applications

Antibacterial Bio-Based Polymers for Cranio-Maxillofacial Regeneration Applications

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