Characteristics of Cord Blood Stem Cells: Role of Substance P (SP) and Calcitonin Gene-Related Peptide (CGRP)

Ebtekar, Massoumeh; Shahrokhi, Somayeh

doi:10.1007/978-94-007-2016-9_3

Cited by 1 publication

(1 citation statement)

References 32 publications

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“…However, until recently, enough evidence regarding the role of neuropeptides on UCB CD34 + ‏ cells was not available. Research had indicated that inclusion of biological mediators other than cytokines, such as neuropeptides would be valuable for optimization of UCB-HSC ex vivo expansion and shortening engraftment time [61]. Accordingly, once the role of substance P (SP) and calcitonin-gene-related neuropeptides (CGRP) on the expansion of UCB CD34 + cells was investigated [62], results showed maximum expansion in 10 −9 M of neuropeptides in short time culture.…”

Section: Approaches To Improve Cord Blood Stem Cell Expansion and mentioning

confidence: 99%

Insights and Hopes in Umbilical Cord Blood Stem Cell Transplantations

Shahrokhi

Menaa

McGuckin

et al. 2012

Journal of Biomedicine and Biotechnology

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Over 20.000 umblical cord blood transplantations (UCBT) have been carried out around the world. Indeed, UCBT represents an attractive source of donor hematopoietic stem cells (HSCs) and, offer interesting features (e.g., lower graft-versus-host disease) compared to bone marrow transplantation (BMT). Thereby, UCBT often represents the unique curative option against several blood diseases. Recent advances in the field of UCBT, consisted to develop strategies to expand umbilical stem cells and shorter the timing of their engraftment, subsequently enhancing their availability for enhanced efficacy of transplantation into indicated patients with malignant diseases (e.g., leukemia) or non-malignant diseases (e.g., thalassemia major). Several studies showed that the expansion and homing of UCBSCs depends on specific biological factors and cell types (e.g., cytokines, neuropeptides, co-culture with stromal cells). In this review, we extensively present the advantages and disadvantages of current hematopoietic stem cell transplantations (HSCTs), compared to UBCT. We further describe the importance of cord blood content and obstetric factors on cord blood selection, and report the recent approaches that can be undertook to improve cord blood stem cell expansion as well as engraftment. Eventually, we provide two majors examples underlining the importance of UCBT as a potential cure for blood diseases.

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Section: Approaches To Improve Cord Blood Stem Cell Expansion and mentioning

confidence: 99%